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Millipore/AB1591P | Anti-Dopamine Transporter Antibody/AB1591P/50 µg
Millipore/AB1591P | Anti-Dopamine Transporter Antibody/AB1591P/50 µg
市场价：
¥6580.00
美元价：
3948.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Description | |
|---|---|
| CatalogueNumber | AB1591P |
| BrandFamily | Chemicon® |
| TradeName |
|
| Description | Anti-DopamineTransporterAntibody |
| AlternateNames |
|
| BackgroundInformation | Plasmalemmalneurotransmittertransporterssequestersynapticandperisynaptictransmitterintopresynapticelements.TheDopamineTransporter(DAT)isresponsIBLeforthereaccumulationofdopamineafterithasbeenreleased.LevelsofDATproteinexpressionarealteredbychronicdrugadmiNISTration.TheactivityoftheDATreuptakecarrierissodiumdependent,anditissUSPectedtoplayaroleinsuchneurologicandpsychiatricdisordersasParkinson"sdisease,Tourette"sdisease,schizophrenia,andaddiction.Itisa12transmembranedomaintransporterwiththeNandCterminalregionslocatedwithinthecytoplasm. |
| ProductInformation | |
|---|---|
| Format | AffinityPurified |
| Control |
|
| Presentation | AffinityPurifiedimmunoglobulin.LiquidinPBScontaining0.1%BSA |
| StorageandShippingInformation | |
|---|---|
| StorageConditions | Maintainfor1yearat-20°Cfromdateofshipment.Aliquottoavoidrepeatedfreezingandthawing.Formaximumrecoveryofproduct,centrifugetheoriginalvialafterthawingandpriortoremovingthecap. |
| Applications | |
|---|---|
| Application | DetectDopamineTransporterusingthisAnti-DopamineTransporterAntibodyvalidatedforuseinELISA,IH,IP&WB. |
| KeyApplications |
|
| ApplicationNotes | Westernblot:1-10μg/mLusingECL.Anantibodyraisedagainstasimilarpeptidehasbeenshowntoreactwithabroad75-80kDabandinratstriatum(Hastrupetal.,2001)andnotcerebellum.RatDATcontainsvariouscarbohydratemoietiesandneuraminidaseandN-Glycanasetreatmentreducesitsmolecularweighttoabout55kDa. Immunoprecipitation:2-10μgofantibody(Changetal.,2001) Immunohistochemistry:1:250-1:500onfrozensectionsoftissuesfixedwith4%paraformaldehyde(Changetal.,2001;Ourednik,etal.,2002).0.05%trypsinfor10-15minhasbeenfoundeffectiveinexposingtheepitopeinsomepreparations. ELISA:0.5-1.0μg/mLusing1μg/mLofDATcontrolpeptide(CatalogNumberAG296)perwell. Optimalworkingdilutionsmustbedeterminedbyenduser. |
| BIOLOGicalInformation | |
|---|---|
| Immunogen | An18aminoacidpeptidesequenceneartheNH2-terminusofratbraindopaminetransportercoupledtoKLH(Kiltyetal.1991;Girosetal.1991;Shimadaetal.1991;Kitayma1992).Thisregionispresumablythecytoplasmicdomain. |
| Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. |
| Host | Rabbit |
| Specificity | RecognizesDopaminetransporter(DAT).ByWesternblottheantibodyrecognizesabroad80kDabandinratstriatum(Lewetal.1992;Freedetal.1995;Vaughanetal.1996)andnotcerebellum.RatDATcontainsvariouscarbohydratemoietiesandneuraminidaseandN-Glycanasetreatmentreducesitsmolecularweighttoabout55kDa. |
| SpeciesReactivity |
|
| AntibodyType | PolyclonalAntibody |
| EntrezGeneNumber | |
| EntrezGeneSummary | Thedopaminetransporter(DAT1)mediatestheactivereuptakeofdopaminefromthesynapseandisaprincipalregulatorofdopaminergicneurotransmission.TheDAT1genehasbeenimplicatedinhumandisorderssuchasparkinsonism,Tourettesyndrome,andsubstanceabuse(Vandenberghetal.,1992[PubMed1359373]).[suppliedbyOMIM] |
| GeneSymbol |
|
| PurificationMethod | ImmunoAffinityPurified |
| UniProtNumber | |
| UniProtSummary | FUNCTION:SwissProt:Q01959#Aminetransporter.Terminatestheactionofdopaminebyitshighaffinitysodium-dependentreuptakeintopresynapticterminals. SIZE:620aminoacids;68495Da SUBUNIT:Homooligomer;disulfide-linked.InteractswithPRKCABPandTGFB1I1. SUBCELLULARLOCATION:Membrane;Multi-passmembraneprotein. SIMILARITY:SwissProt:Q01959##Belongstothesodium:neurotransmittersymporter(SNF)family. MISCELLANEOUS:Thisproteinisthetargetofpsychomotorstimulantssuchasamphetaminesorcocaine. |
| MolecularWeight | 80kDa |
| PhysicochemicalInformation |
|---|
| Dimensions |
|---|
| MaterialsInformation |
|---|
| MaterialsInformation |
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品牌介绍
密理博(Millipore)公司成立于1954年，总部位于美国麻省，在全世界设有47个办事处，为100多个国家提供产品和技术服务。目前全球雇员超过5800人，在美国、法国和日本等国家拥有7家大型生产工厂，主要生产过滤膜及膜过滤产品。20世纪80年代，密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构，并于2000年4月在上海浦东外高桥保税区建立了密理博（上海）贸易有限公司。为了更好地满足中国用户的需求，密理博中国主页于2006年11月向广大用户开放，介绍密理博中国有限公司的最新动态，力求为用户打造专业的产品与服务信息交流平台。
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