微孔/AB143 |抗胆碱乙酰转移酶（ChAT）抗体/AB143/50µ；L
市场价：
¥6980.00
美元价：
4188.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Description | |
|---|---|
| CatalogueNumber | AB143 |
| BrandFamily | Chemicon® |
| TradeName |
|
| Description | Anti-CholineAcetyltransferase(ChAT)Antibody |
| AlternateNames |
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| BackgroundInformation | Acetylcholine(ACh)isacommonneurotransmitterformotoneurons,preganglionicautonomicneurons,postganglionicparasympatheticneurons,avarietyofbrainregionsandsomeemergingneuron-likestemcells.ThemetabolismofAchisrelativelysimple,involvingonlytwoenzymes:cholineacetyltransferase(ChAT)forsynthesisandacetylcholinesterase(AChE)fordegradation.Further,acetylcholinehaslittlefunctioninneuronsotherthanneurotransmissionandseemstobeneuronspecific.ItseemsthatonlycholinergicneuronshavesignificantamountsofChATmakinganti-cholinacetyltransferaseausefulspecificMarker. |
| ProductInformation | |
|---|---|
| Format | Serum |
| Control |
|
| Presentation | Rabbitpolyclonalantisera,liquid,nopreservatives. |
| StorageandShippingInformation | |
|---|---|
| StorageConditions | Stablefor1yearat-20°Cinundilutedaliquotsfromdateofreceipt. HandlingRecommendations:Uponfirstthaw,andpriortoremovingthecap,centrifugethevialandgentlymixthesolution.Aliquotintomicrocentrifugetubesandstoreat-20°C.Avoidrepeatedfreeze/thawcycles,whichmaydamageIgGandaffectproductperformance. |
| Applications | |
|---|---|
| Application | Anti-CholineAcetyltransferase(ChAT)AntibodyisanantibodyagainstCholineAcetyltransferase(ChAT)foruseinIH,IH(P),IP&WBwithmorethan70productcitations. |
| KeyApplications |
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| ApplicationNotes | Immunoprecipitation: 1:200dilutionofapreviouslotimmunoprecipitated68kDaactiveChATfrombrainandplacenta.Alsoprecipitatesa27kDaproteinthatisco-expressedwithChAT(butlackingChATactivity)insomecholinergicneuronsofthecentralnervoussystemofHumansandpossIBLyothermammals. Optimalworkingdilutionsandprotoclsmustbedeterminedbyenduser. |
| BIOLOGicalInformation | |
|---|---|
| Immunogen | Humanplacentalenzyme. |
| Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. |
| Host | Rabbit |
| Specificity | Cholinergicneuronsinbrainandcentralnervoussystems. |
| SpeciesReactivity |
|
| SpeciesReactivityNote | Human,Mouse,Rat,Monkey,Bat,Feline.ReactivitywithotherspecieshasnotbeenconfirmedwithIHC. |
| AntibodyType | PolyclonalAntibody |
| EntrezGeneNumber | |
| EntrezGeneSummary | Thisgeneencodesanenzymewhichcatalyzesthebiosynthesisoftheneurotransmitteracetylcholine.Thisgeneproductisacharacteristicfeatureofcholinergicneurons,andchangesintheseneuronsmayexplainsomeofthesymptomsofAlzheimerdisease.Mutationsinthisgeneareassociatedwithcongenitalmyasthenicsyndromeassociatedwithepisodicapnea.Multipletranscriptvariantsencodingdifferentisoformshavebeenfoundforthisgene,andsomeofthesevariantshavebeenshowntoencodemorethanoneisoform.[providedbyRefSeq]. TranscriptVariant:Thisvariant(M)containsalternate5"exonM,usesanupstreamstartcodon,andencodesisoform2. |
| GeneSymbol |
|
| PurificationMethod | Unpurified |
| UniProtNumber | |
| UniProtSummary | FUNCTION:SwissProt:P28329#Catalyzesthereversiblesynthesisofacetylcholine(ACh)fromacetylCoAandcholineatcholinergicsynapses. SIZE:748aminoacids;82568Da DISEASE:SwissProt:P28329#DefectsinCHATarethecauseoffamilialinfantilemyastheniagravis2(FIMG2)[MIM:254210,254200];alsoknownasCMS-EA.FIMG2patientshavemyasthenicsymptomssincebirthorearlyinfancy,negativetestsforanti-AChRantibodies,andabruptepisodiccriseswithincreasedweakness,bulbarparalysis,andapneaprecipitatedbyundueexertion,fever,orexcitement.Inheritanceisautosomalrecessive. SIMILARITY:SwissProt:P28329##Belongstothecarnitine/cholineacetyltransferasefamily. |
| PhysicochemicalInformation |
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| Dimensions |
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| MaterialsInformation |
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| MaterialsInformation |
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品牌介绍
密理博(Millipore)公司成立于1954年，总部位于美国麻省，在全世界设有47个办事处，为100多个国家提供产品和技术服务。目前全球雇员超过5800人，在美国、法国和日本等国家拥有7家大型生产工厂，主要生产过滤膜及膜过滤产品。20世纪80年代，密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构，并于2000年4月在上海浦东外高桥保税区建立了密理博（上海）贸易有限公司。为了更好地满足中国用户的需求，密理博中国主页于2006年11月向广大用户开放，介绍密理博中国有限公司的最新动态，力求为用户打造专业的产品与服务信息交流平台。
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