Millipore/MABT26 |抗E-钙粘蛋白抗体，克隆DECMA-1/MABT26/100µ；G
市场价：
¥6580.00
美元价：
3948.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Description | |
|---|---|
| CatalogueNumber | MABT26 |
| Description | Anti-E-cadherinAntibody,cloneDECMA-1 |
| AlternateNames |
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| BackgroundInformation | CadherinsareafamilyoftransmembraneglycoproteinsinvolvedinCa2+-dependentcelltocellinteractions.Themembersofthefamilyaredifferentiallyexpressedinvarioustissuesandfunctioninthemaintenanceoftissueintegrity,morphogenesis,andmigration.CadherinsaredividedintotypeIandtypeIIsubgroups.TypeIcadherinsincludeepithelialcadherin(E-cadherin),neuralcadherin(N-cadherin),placentalcadherin(P-cadherin)andretinalcadherin(R-cadherin).TypeIIincludekidneycadherin(K-cadherin)andosteoblastcadherin(OB-cadherin).OneofthebestcharacterizedcadherinsisE-cadherin(epithelialcadherinorcadherin-1).Itconsistsofcalcium-bindingextracellulardomainsresponsIBLeforinteractionswithotherE-cadherinmoleculesonneighboringcellsandinteractionwithintegrinalphaEbeta7.ThecytoplasmicdomainofE-cadherinislinkedtotheactinCytoskeletonthroughcytoplasmiccateninproteins,thusestablishingacomplexlocalizedtoadherensjunctions.Incarcinomas,E-cadherinisfrequentlydownregulated,consistentwithitsfunctionofaninvasionsuppressorinnormalepithelia. |
| ProductInformation | |
|---|---|
| Format | Purified |
| Control |
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| Presentation | PurifiedratmonoclonalIgG1κinbuffercontainingPBSwithoutpreservative. |
| StorageandShippingInformation | |
|---|---|
| StorageConditions | Stablefor1yearat-20°Cfromdateofreceipt. HandlingRecommendations:Uponreceiptandpriortoremovingthecap,centrifugethevialandgentlymixthesolution.Aliquotintomicrocentrifugetubesandstoreat-20°C.Avoidrepeatedfreeze/thawcycles,whichmaydamageIgGandaffectproductperformance. |
| BIOLOGicalInformation | |
|---|---|
| Immunogen | MouseembryonalcarcinomacelllinePCC4 |
| Clone | Decma-1 |
| Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. |
| Host | Rat |
| Isotype | IgG1κ |
| SpeciesReactivity |
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| AntibodyType | MonoclonalAntibody |
| EntrezGeneNumber | |
| GeneSymbol |
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| PurificationMethod | ProteinG |
| UniProtNumber | |
| UniProtSummary | FUNCTION:Cadherinsarecalcium-dependentcelladhesionproteins.Theypreferentiallyinteractwiththemselvesinahomophilicmannerinconnectingcells;cadherinsmaythuscontributetothesortingofheterogeneouscelltypes.CDH1isinvolvedinmechanismsregulatingcell-celladhesions,mobilityandproliferationofepithelialcells.Hasapotentinvasivesuppressorrole.Itisaligandforintegrinalpha-E/beta-7(bysimilarity). E-Cad/CTF2promotesnon-amyloidogenicdegradationofAbetaprecursors.HasastronginhibitoryeffectonAPPC99andC83production(bysimilarity). SUBUNITSTRUCTURE:Homodimer;disulfide-linked.Interactsdirectly,viathecytoplasmicdomain,withCTNNB1orJUPtoformthePSEN1/cadherin/cateninadhesioncomplexwhichconnectstotheactinskeletonthroughtheactinbindingofalpha-catenin.InteractionwithPSEN1,cleavesCDH1resultinginthedisassociationofcadherin-basedadherensjunctions(CAJs).InteractswithAJAP1,CTNND1andDLGAP5(bysimilarity). SUBCELLULARLOCATION:Celljunction.Cellmembrane;Single-passtypeImembraneprotein.Note:ColocalizeswithDLGAP5atsitesofcell-cellcontactinintestinalepithelialcells.AnchoredtoactinMICROFILamentsthroughassociationwithalpha-,beta-andgamma-catenin.Sequentialproteolysisinducedbyapoptosisorcalciuminflux,resultsintranslocationfromsitesofcell-cellcontacttothecytoplasm(bysimilarity). TISSUESPECIFICTY:Non-neuralepithelialtissues. DEVELOPMENTALSTAGE:Inthetestis,expressionishighestinfetalgonad,thendecreases5-foldinnewborn.Detectablein7-day-oldbutnotin21-day-oldoradult. SEQUENCESIMILARITIES:Contains5cadherindomains. |
| MolecularWeight | ~106kDaobservedMW. |
| PhysicochemicalInformation |
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| Dimensions |
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| MaterialsInformation |
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| MaterialsInformation |
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品牌介绍
密理博(Millipore)公司成立于1954年，总部位于美国麻省，在全世界设有47个办事处，为100多个国家提供产品和技术服务。目前全球雇员超过5800人，在美国、法国和日本等国家拥有7家大型生产工厂，主要生产过滤膜及膜过滤产品。20世纪80年代，密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构，并于2000年4月在上海浦东外高桥保税区建立了密理博（上海）贸易有限公司。为了更好地满足中国用户的需求，密理博中国主页于2006年11月向广大用户开放，介绍密理博中国有限公司的最新动态，力求为用户打造专业的产品与服务信息交流平台。
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