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当前位置: 首页 > 产品中心 > Functional_antibody > Millipore/MABN497 | Anti-PSD93 Antibody, clone N18/30/MABN497/100 µg
商品详细Millipore/MABN497 | Anti-PSD93 Antibody, clone N18/30/MABN497/100 µg
Millipore/MABN497 | Anti-PSD93 Antibody, clone N18/30/MABN497/100 µg
Millipore/MABN497 | Anti-PSD93 Antibody, clone N18/30/MABN497/100 µg
商品编号: MABN497
品牌: 密理博
市场价: ¥6160.00
美元价: 3696.00
产地: 美国(厂家直采)
公司:
产品分类: 功能性抗体
公司分类: Functional_antibody
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍
Description
CatalogueNumberMABN497
DescriptionAnti-PSD93Antibody,cloneN18/30
AlternateNames
  • Diskslargehomolog2
  • Channel-associatedproteinofsynapse-110
  • Chapsyn-110
  • PostsynapticdensityproteinPSD-93
BackgroundInformationAsamemberofthemembrane-associatedguanylatekinase(MAGUK)family,PSD93(alsoknownasChapsyn-110)bindsdirectlytotheN-methyl-D-aspartate(NMDA)receptorandtheShakerK+channelsubunits.Itshares70-80%homologywithPSD-95(SAP90),andSAP97.LikePSD-95,PSD93playsakeyroleinpostsynaptictargeting.Asidefrombindingtoglutamatereceptors,theMAGUKfamilyofproteinsalsointeractswithcellsurfacestructures,likecelladhesionmolecules,ionchannels,cytoskeletalelements,andsignaltransductionmolecules.ImproperPSD93signalinghasbeenimplicatedincertaindiseasestates,suchasschizophrenia.
ProductInformation
FormatPurified
Control
  • Mousebraintissuelysate
PresentationPurifiedmousemonoclonalIgG1inbuffercontaining0.1MTris-Glycine(pH7.4),150mMNaClwith0.05%sodiumazide.
StorageandShippingInformation
StorageConditionsStablefor1yearat2-8°Cfromdateofreceipt.
Applications
ApplicationDetectPSD93usingthisAnti-PSD93Antibody,cloneN18/30validatedforuseinWesternBlotting&IHC.
KeyApplications
  • WesternBlotting
  • Immunohistochemistry
ApplicationNotesWesternBlotAnalysis:1µg/mLfromarepresentativelotdetectedPSD93in10µgofhumanbraintissuelysate.

ImmunohistochemistryAnalysis:ArepresentativelotdetectedPSD93inratbraintissue(Prof.J.Trimmer,UniversityofCalifornia,Davis).

WesternBlotAnalyis:ArepresentativelotdetectedPSD93inWT,butnotinPSD93knockoutmice.

WesternBlotAnalysis:ArepresentativelotdetectedPSD93inCA1tissuelysatesfromC57BL/6mice(Jeffrey,R.A.,etal.(2009).JNeurosci.29(50):15613-15620.).
BIOLOGicalInformation
ImmunogenRecombinantproteincorrespondingtoratPSD93.
CloneN18/30
ConcentrationPleaserefertotheCertificateofAnalysisforthelot-specificconcentration.
HostMouse
IsotypeIgG1κ
SpeciesReactivity
  • Mouse
  • Human
  • Rat
SpeciesReactivityNoteDemonstratedtoreactwithMouse,Human,andRat.ThisantibodydoesnotdemonstratecrossreactivitywithotherMAGUKfamilymembers,suchasPSD-95,SAP97,andSAP102expressedintransfectedcells.
AntibodyTypeMonoclonalAntibody
EntrezGeneNumber
GeneSymbol
  • Dlg2
  • Dlgh2
PurificationMethodProteinGPurified
UniProtNumber
MolecularWeight~110kDaobserved.ThecalculatedmolecularweightofPSD93is95kDa;however,thisproteinishighlyphosphorylatedandisobservedat~110kDa.Multipleisoformsbetween68-98kDaareknowntoexist.
PhysicochemicalInformation
Dimensions
MaterialsInformation
MaterialsInformation
品牌介绍
密理博(Millipore)公司成立于1954年,总部位于美国麻省,在全世界设有47个办事处,为100多个国家提供产品和技术服务。目前全球雇员超过5800人,在美国、法国和日本等国家拥有7家大型生产工厂,主要生产过滤膜及膜过滤产品。20世纪80年代,密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构,并于2000年4月在上海浦东外高桥保税区建立了密理博(上海)贸易有限公司。为了更好地满足中国用户的需求,密理博中国主页于2006年11月向广大用户开放,介绍密理博中国有限公司的最新动态,力求为用户打造专业的产品与服务信息交流平台。