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Millipore/MAB5402 | Anti-Dynamin 1 Antibody, neuronal specific, clone D5/MAB5402/100 µg
Millipore/MAB5402 | Anti-Dynamin 1 Antibody, neuronal specific, clone D5/MAB5402/100 µg
市场价：
¥6580.00
美元价：
3948.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Description | |
|---|---|
| CatalogueNumber | MAB5402 |
| BrandFamily | Chemicon® |
| TradeName |
|
| Description | Anti-Dynamin1Antibody,neuronalspecific,cloneD5 |
| BackgroundInformation | Dynaminisa100kDaGTPbindingproteinthatwasfirstidentifiedasaproteinabletobindmicrotubules.AmutationintheDrosophilageneshits,encodingadynaminhomologue,preventssynapticvesiclerecyclingandcausestemperature-sensitiveparalysis, implicatingdynaminintheformationofcoatedvesicles.Dynaminmaymediatevesicleformationbyassemblingintoaringstructurearoundthenecksofinvaginatedcoatedpitsthatmayeventuallyleadtotheclosureoftheneckandformationofvesicles.Amphiphysin,dynamin,clathrinandAP2formacomplexduringsynapticvesicleendocytosis,whichisregulatedbythephosphorylatedstateofdifferentcomponentsinthiscomplex.To date,threegeneshavebeenfoundtoencodedynaminisoforms.Dynamin1isneuronalspecific,Dynamin2isubiquitouslyexpressedandDynamin3localizestotestis,brainandlung. |
| ProductInformation | |
|---|---|
| Format | Purified |
| Presentation | Purifiedimmunoglobulin.Liquidcontaining0.1%sodiumazide. |
| StorageandShippingInformation | |
|---|---|
| StorageConditions | Maintainat2-8°Cinundilutedaliquotsforupto6monthsafterdateofreceipt. ImportantNote:Duringshipment,smallvolumesofproductwilloccasionallybecomeentrappedinthesealoftheproductvial.Forproductswithvolumesof200μLorless,werecommendgentlytappingthevialonahardsurfaceorbrieflycentrifugingthevialinatabletopcentrifugetodislodgeanyliquidinthecontainer"scap. |
| BIOLOGicalInformation | |
|---|---|
| Immunogen | RecombinantHis-taggedfusionprotein,correspondingtoaminoacids1-750ofHumanDynamin1. |
| Epitope | neuronalspecific |
| Clone | D5 |
| Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. |
| Host | Mouse |
| Specificity | ReactsDynamin1.Microtubuleassociatedprotein |
| Isotype | Ig |
| SpeciesReactivity |
|
| AntibodyType | MonoclonalAntibody |
| EntrezGeneNumber | |
| EntrezGeneSummary | ThisgeneencodesamemberofthedynaminsubfamilyofGTP-bindingproteins.Theencodedproteinpossessesuniquemechanochemicalpropertiesusedtotubulateandsevermembranes,andisinvolvedinclathrin-mediatedendocytosisandothervesiculartraffickingprocesses.Actinandothercytoskeletalproteinsactasbindingpartnersfortheencodedprotein,whichcanalsoself-assembleleADIngtostimulationofGTPaseactivity.Morethansixtyhighlyconservedcopiesofthe3"regionofthisgenearefoundelsewhereinthegenome,particularlyonchromosomesYand15.Alternativelysplicedtranscriptvariantsencodingdifferentisoformshavebeendescribed. |
| GeneSymbol |
|
| UniProtNumber | |
| UniProtSummary | FUNCTION:SwissProt:Q05193#Microtubule-associatedforce-producingproteininvolvedinproducingmicrotubulebundlesandabletobindandhydrolyzeGTP.Mostprobablyinvolvedinvesiculartraffickingprocesses,inparticularendocytosis. SIZE:864aminoacids;97407Da SUBUNIT:InteractswithCAV1andSH3GLB1.BindsSH3GL1,SH3GL2andSH3GL3(Bysimilarity). SUBCELLULARLOCATION:Cytoplasm.Cytoplasm,Cytoskeleton.Note=Microtubule-associated. SIMILARITY:SwissProt:Q05193##Belongstothedynaminfamily.&Contains1GEDdomain.&Contains1PHdomain. |
| PhysicochemicalInformation |
|---|
| Dimensions |
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| MaterialsInformation |
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| MaterialsInformation |
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品牌介绍
密理博(Millipore)公司成立于1954年，总部位于美国麻省，在全世界设有47个办事处，为100多个国家提供产品和技术服务。目前全球雇员超过5800人，在美国、法国和日本等国家拥有7家大型生产工厂，主要生产过滤膜及膜过滤产品。20世纪80年代，密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构，并于2000年4月在上海浦东外高桥保税区建立了密理博（上海）贸易有限公司。为了更好地满足中国用户的需求，密理博中国主页于2006年11月向广大用户开放，介绍密理博中国有限公司的最新动态，力求为用户打造专业的产品与服务信息交流平台。
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