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Millipore/MAB5258-20UG | Anti-Synaptophysin Antibody, clone SY38/MAB5258-20UG/20 µg
Millipore/MAB5258-20UG | Anti-Synaptophysin Antibody, clone SY38/MAB5258-20UG/20 µg
商品编号：
MAB5258-20UG
品牌：
密理博
市场价：
¥5960.00
美元价：
3576.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Description | |
|---|---|
| CatalogueNumber | MAB5258-20UG |
| Replaces | 04-1019 |
| BrandFamily | Chemicon® |
| TradeName |
|
| Description | Anti-SynaptophysinAntibody,cloneSY38 |
| AlternateNames |
|
| BackgroundInformation | Synaptophysinisa38kDaglycoproteinpresentinthemembraneofneuronalpresynapticvesiclesinbrain,spinalcord,retina,vesiclesofadrenalmedulla,neuromuscularjunctions,andendocrinecells.Itisalsoexpressedbyneuroendocrinecellsthroughoutthebody,bothnormalandneoplastic.SynaptophysinisausefulMarkerfortheidentificationofnormalneuroendocrinecellsandneuroendocrineneoplasms.Thisantibodyreactswithneuroendocrinecellsofhumanadrenalmedulla,carotidbody,skin,pituitarygland,thyroid,lung,pancreas,andgastointestinalmucosa.Italsoreactswithawidespectrumofneuroendocrineneoplasmsofneuraltypeincludingneuroblastomas,ganglioneuroblastomas,ganglioneuromas,pheochromocytomas,chromaffin,andnonchromaffinparagangliomas. |
| ProductInformation | |
|---|---|
| Format | Purified |
| Control |
|
| Presentation | PurifiedmousemonoclonalIgG1κinbuffercontaining20mMsodiumphosphatebuffer,0.25MNaCl,containing0.1%sodiumazide. |
| StorageandShippingInformation | |
|---|---|
| StorageConditions | Stablefor6monthsat2-8ºCfromdateofreceipt.DONOTFREEZE. |
| BIOLOGicalInformation | |
|---|---|
| Immunogen | Vesicularfractionofbovinebrain.TheSY38epitopeistoapentapeptiderepeatstructureinthecarboxy-terminalcytoplasmictailofsynaptophysin(Knaus&Betz1990). |
| Clone | SY38 |
| Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. |
| Host | Mouse |
| Specificity | Theantibodyreactswithpresynapticvesiclesofcerebralandspinalneurons,ofneuromuscularendplatesandwiththeretinaofman,cow,ratandmouse.Theantibodyalsoreactswithvesiclesofadrenalmedullaandisletcells,andadditionallyallowsspecificstainingofneuronal,adrenalandneuroepithelialtumors,suchaspheochromocytoma,paraganglioma,isletcelltumors(incl.Insulinoma),medullarythyroidcarcinomaanddiversepulmonaryandgastro-intestinalcarcinoids.Theantibodyalsostainsneurosecretoryvesiclesofcertainculturecells,e.g.oftheratcelllinePC-12. |
| Isotype | IgG1κ |
| SpeciesReactivity |
|
| AntibodyType | MonoclonalAntibody |
| EntrezGeneNumber | |
| EntrezGeneSummary | Synaptophysin(p38)isanintegralmembraneproteinofsmallsynapticvesiclesinbrainandendocrinecells.[suppliedbyOMIM] |
| GeneSymbol |
|
| PurificationMethod | ProteinAPurfied |
| UniProtNumber | |
| UniProtSummary | FUNCTION:SwissProt:P08247#PossIBLyinvolvedinstructuralfunctionsasorganizingothermembranecomponentsorintargetingthevesiclestotheplasmamembrane. SIZE:313aminoacids;33845Da SUBUNIT:Homohexamerorhomotetramer. SUBCELLULARLOCATION:Cytoplasmicvesicle,secretoryvesicle,synapticvesiclemembrane;Multi-passmembraneprotein. TISSUESPECIFICITY:Characteristicofatypeofsmall(30-80nm)neurosecretoryvesicles,includingpresynapticvesicles,butalsovesiclesofvariousneuroendocrinecellsofbothneuronalandepithelialphenotype. DOMAIN:SwissProt:P08247Thecalcium-bindingactivityisthoughttobelocalizedinthecytoplasmictailoftheprotein. PTM:Ubiquitinated;mediatedbySIAH1orSIAH2andleADIngtoitssubsequentproteasomaldegradation(Bysimilarity). SIMILARITY:Belongstothesynaptophysin/synaptobrevinfamily.&Contains1MARVELdomain. |
| MolecularWeight | 38kDa |
| PhysicochemicalInformation |
|---|
| Dimensions |
|---|
| MaterialsInformation |
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| MaterialsInformation |
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品牌介绍
密理博(Millipore)公司成立于1954年，总部位于美国麻省，在全世界设有47个办事处，为100多个国家提供产品和技术服务。目前全球雇员超过5800人，在美国、法国和日本等国家拥有7家大型生产工厂，主要生产过滤膜及膜过滤产品。20世纪80年代，密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构，并于2000年4月在上海浦东外高桥保税区建立了密理博（上海）贸易有限公司。为了更好地满足中国用户的需求，密理博中国主页于2006年11月向广大用户开放，介绍密理博中国有限公司的最新动态，力求为用户打造专业的产品与服务信息交流平台。
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