Millipore/MAB1598 |抗突触后密度蛋白95抗体，克隆7E3-1B8/MAB1598/100µ；G
市场价：
¥7180.00
美元价：
4308.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Description | |
|---|---|
| CatalogueNumber | MAB1598 |
| Replaces | 04-1066 |
| BrandFamily | Chemicon® |
| TradeName |
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| Description | Anti-PostSynapticDensityProtein95Antibody,clone7E3-1B8 |
| AlternateNames |
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| BackgroundInformation | Thepostsynapticdensity(PSD)isanelectrondensestructurejustbeneaththepostsynapticmembrane.SeveralfunctionshavebeenproposedforthePSDincludingregulatingreceptornumberandclustering,anchoringsignaltransductionmoleculesatthesynapseandmediatingadhesionbetweenthepresynapticandpostsynapticmembranes.ThemostabundantPSDproteinisthe[alpha]subunitofthetypeIIcalcium/calmodulindependentproteinkinase([alpha]CaMKII).Thisproteinislikelytoplayaroleinthecalcium-mediatedsignaltransductionatthesynapsethatmediatescertainformsofsynapticplasticity.AnothermajorPSDproteinisPSD-95,amemberoftheguanylatekinasefamily(GUK)ofproteins. |
| ProductInformation | |
|---|---|
| Format | Purified |
| Control |
|
| Presentation | PurifiedmoustmonoclonalIgG2aliquidinbuffercontainingPBS,pH7.2,with0.09%sodiumazideand50%glycerol. |
| StorageandShippingInformation | |
|---|---|
| StorageConditions | Stablefor1yearat-20ºCfromdateofreceipt. |
| BIOLOGicalInformation | |
|---|---|
| Immunogen | RecombinantratPSD-95 |
| Clone | 7E3-1B8 |
| Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. |
| Host | Mouse |
| Specificity | ReactswithrecombinantratPSD-95andidentifiesabandatapproximately~100kDa,correspondingtoPSD-95,onwesternblotsofratbrain,mousebrainandbovinebrainextracts.Alsopresentinratbrainandmousebraintissueextractsarebandsofapproximately80kDaand50kDa.PSD-95isbelievedtoinitiateNMDAreceptorclusteringonthepostsynapticmembrane. |
| Isotype | IgG2a |
| SpeciesReactivity |
|
| SpeciesReactivityNote | Expectedtoreactwithhumanbasedonsequencehomology |
| AntibodyType | MonoclonalAntibody |
| EntrezGeneSummary | Thisgeneencodesamemberofthemembrane-associatedguanylatekinase(MAGUK)family.ItheteromultimerizeswithDLG2.WithDLG2itisrecruitedintothesameNMDAreceptorandpotassiumchannelclusters.ThesetwoMAGUKproteinsmayinteractatpostsynapticsitestoformamultimericscaffoldfortheclusteringofreceptors,ionchannels,andassociatedsignalingproteins. |
| PurificationMethod | ProteinGPurified |
| UniProtNumber | |
| UniProtSummary | FUNCTION:SwissProt:P78352#InteractswiththecytoplasmictailofNMDAreceptorsubunitsandshaker-typepotassiumchannels.RequiredforsynapticplasticityassociatedwithNMDAreceptorsignaling.OverexpressionordepletionofDLG4changestheratioofexcitatorytoinhibitorysynapsesinhippocampalneurons.MayreducetheamplitudeofACCN3acid-evokedcurrentsbyretainingthechannelintracellularly.MayregulatetheintracellulartraffickingofADR1B(Bysimilarity). SIZE:724aminoacids;80495Da SUBUNIT:InteractsthroughitsfirsttwoPDZdomainswithGRIN2A,GRIN2B,GRIN2C,GRIN2D,ACCN3,certainspliceformsofGRIN1,KCND2,CXADRandSYNGAP1.InteractsthroughitssecondPDZdomainwiththePDZdomainofNOS1ortheC-terminusofCAPON.MayinteractwithHTR2A.Interactsthroughitsguanylatekinase-likedomainwithDLGAP1/GKAP,DLGAP2,DLGAP3,DLGAP4,MAP1A,andBEGAIN(Bysimilarity).InteractsthroughitsfirsttwoPDZdomainswithKCNA1,KCNA2,KCNA3,KCNA4andERBB4.InteractsthroughitsfirstPDZdomainwithGRIK2,KCNA4andCRIPT.InteractsthroughitsthirdPDZdomainwithNLGN1,andprobablywithNLGN2andNLGN3.Interactsthroughitsguanylatekinase-likedomainwithKIF13B.Isoform2interactsthroughanL27domainwithHGS/HRSandthefirstL27domainofCASK. SUBCELLULARLOCATION:Cellmembrane;Peripheralmembraneprotein.Celljunction,synapse,postsynapticcellmembrane,postsynapticdensity.Celljunction,synapse.Note=Highlevelsinpostsynapticdensityofneuronsintheforebrain.AlsoinpresynapticregionofinhibitorysynapsesformedbycerebellarbasketcellsonaxonhillocksofPurkinjecells. TISSUESPECIFICITY:Brain. DOMAIN:SwissProt:P78352ThePDZdomain3mediatesinteractionwithADR1B.&TheL27domainneartheN-terminusofisoform2isrequiredforHGS/HRS-dependenttargetingtopost-synapticdensity. PTM:Palmitoylationofisoform1isrequiredfortargetingtopostsynapticdensity(Bysimilarity). SIMILARITY:BelongstotheMAGUKfamily.&Contains1guanylatekinase-likedomain.&Contains3PDZ(DHR)domains.&Contains1SH3domain. |
| MolecularWeight | ~95kDa |
| PhysicochemicalInformation |
|---|
| Dimensions |
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| MaterialsInformation |
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| MaterialsInformation |
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品牌介绍
密理博(Millipore)公司成立于1954年，总部位于美国麻省，在全世界设有47个办事处，为100多个国家提供产品和技术服务。目前全球雇员超过5800人，在美国、法国和日本等国家拥有7家大型生产工厂，主要生产过滤膜及膜过滤产品。20世纪80年代，密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构，并于2000年4月在上海浦东外高桥保税区建立了密理博（上海）贸易有限公司。为了更好地满足中国用户的需求，密理博中国主页于2006年11月向广大用户开放，介绍密理博中国有限公司的最新动态，力求为用户打造专业的产品与服务信息交流平台。
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