密理博/ABN37 |抗Homer1抗体/ABN37/100µ；G
市场价：
¥6580.00
美元价：
3948.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Description | |
|---|---|
| CatalogueNumber | ABN37 |
| Description | Anti-Homer1Antibody |
| AlternateNames |
|
| BackgroundInformation | Homerproteinhomolog1(UniProtQ86YM7;alsoknownasHomer-1,Homer1)isencodedbytheHOMER1(alsoknownasSYN47)gene(GeneID9456)inhuman.Homer-1,-2,and-3constituteafamilyofpostsynapticscaffoldproteinsthatplayacentralroleincalciumsignaling.HomermembersshareaconservedN-terminalEna/VASPhomology1(EVH1)domain(a.a.1-110ofHomer-1)thatmediatesignalingcomplexesassemblybyinteractingwithPPXXFRproline-richconsensussequencesfoundinvariousotherscaffoldingandsignaltransductionmolecules,includingmetabotropicglutamatereceptors(mGluRs)and1,4,5-trisphosphatereceptors(IP3Rs).InadditiontomediategroupImGluRssignalingviatheirEVH1domain,Homer-1splicedvariantsVesl-1L,1b,and1d,butnotVesl-1MorVesl-1S,alsocontainaC-terminalcoiled-coil(a.a.181-352)regionthatmediateself-multimerization.Homer-1variantsareassociatedwiththeetiologyofmanyneurologicaldiseases,suchaschronicpain,mentalretardationsyndromes,Alzheimer"sdisease(AD),Parkinson"sdisease(PD),schizophrenia,drug-inducedaddiction,andtraumaticbraininjury(TBI).Homer1b/c-knockdownisreportedtoprotectagainstchemicallyinducedseizureinmiceasaresultofpreventingmGluR5-mediatedmTORpathwayactivation. |
| ProductInformation | |
|---|---|
| Format | AffinityPurified |
| Control |
|
| Presentation | Purifiedrabbitpolyclonalantibodyinbuffercontaining0.1MTris-Glycine(pH7.4),150mMNaClwith0.05%sodiumazide. |
| StorageandShippingInformation | |
|---|---|
| StorageConditions | Stablefor1yearat2-8°Cfromdateofreceipt. |
| Applications | |
|---|---|
| Application | Anti-Homer1,Cat.No.ABN37,isahighlyspecificrabbitpolyclonalantibodythattargetsHomerproteinhomolog1andhasbeentestedinImmunohistochemistryandWesternBlotting. |
| KeyApplications |
|
| ApplicationNotes | ImmunohsitochemistryAnalysis:A1:500dilutionfromarepresentativelotdetectedHomer1inhumanandmousecerebralcortextissuesections. ImmunohsitochemistryAnalysis:ArepresentativelotdetectedsignificantlyincreasedstratumrADIatumandstratumoriensHomer1immunoreactivityinfloatingbrainsectionsfrommicereceivedAP-12intraperitonealinjection(Jansone,B.,etal.(2015).PLoSOne.10(6):e0127686). |
| BIOLOGicalInformation | |
|---|---|
| Immunogen | KLH-conjugatedlinearpeptidecorrespondingtoaninternalsequencewithintheN-terminalhalfofhumanHomer1isoform1bandneartheC-terminusofisoform1h. |
| Concentration | Pleaserefertolotspecificdatasheet. |
| Host | Rabbit |
| Specificity | ThisrabbitpolyclonalantibodytargetsaninternalsequencewithintheN-terminalhalfofhumanHomer1isoform1bandmouseisoformVesl-1L.ImmunogensequenceappearsneartheC-terminusofhumanisoform1handmouseisoforms1b,1d,Vesl-1M,andVesl-1S,butabsentinhumanisoform1e.Highlyhomologoussequence(~83%)isalsofoundintheN-terminalhalfofratisoform1c(Vesl-1L)andneartheC-terminusofratisoforms1a(Vesl)and1b. |
| SpeciesReactivity |
|
| SpeciesReactivityNote | Human,Mouse.PredictedtoreactwithHorseandMonkeybasedon100%sequencehomology.Broadspeciesreactivityexpectedbasedonhighsequencehomology. |
| AntibodyType | PolyclonalAntibody |
| EntrezGeneNumber | |
| EntrezGeneSummary | Thisgeneencodesamemberofthehomerfamilyofdendriticproteins.Membersofthisfamilyregulategroup1metabotrophicglutamatereceptorfunction. |
| GeneSymbol |
|
| PurificationMethod | Affinitypurfied. |
| UniProtNumber | |
| MolecularWeight | ~47kDaobserved.40.28/19.86kDa(humanisoform1b/1h),40.22/42.08/41.41/22.78/20.91kDa(mouseisoform1b/1d/Vesl-1L/Vesl-1M/Vesl-1S)calculated.Uncharacterizedbandsmaybeobservedinsomelysate(s). |
| PhysicochemicalInformation |
|---|
| Dimensions |
|---|
| MaterialsInformation |
|---|
| MaterialsInformation |
|---|
品牌介绍
密理博(Millipore)公司成立于1954年，总部位于美国麻省，在全世界设有47个办事处，为100多个国家提供产品和技术服务。目前全球雇员超过5800人，在美国、法国和日本等国家拥有7家大型生产工厂，主要生产过滤膜及膜过滤产品。20世纪80年代，密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构，并于2000年4月在上海浦东外高桥保税区建立了密理博（上海）贸易有限公司。为了更好地满足中国用户的需求，密理博中国主页于2006年11月向广大用户开放，介绍密理博中国有限公司的最新动态，力求为用户打造专业的产品与服务信息交流平台。
联络我们
