Millipore/ABN27 | Anti-GRIP-1 Antibody, CT/ABN27/100 µg
市场价：
¥6980.00
美元价：
4188.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Description | |
|---|---|
| CatalogueNumber | ABN27 |
| Replaces | 06-986 |
| Description | Anti-GRIP-1Antibody,CT |
| AlternateNames |
|
| BackgroundInformation | Glutamatereceptorinteractingprotein-1(GRIP-1)isamulti-PDZdomainscaffoldproteinandamemberofthesteroidreceptorcoactivator(SRC)familyofproteins.GRIP-1interactsandmaneuverskinesinheavychainstodendritesbyactingasthepowersourceforAMPAreceptors.Duringinitialstagesofembryonicdevelopment,GRIP-1isessentialfortypicalcell-matrixinteractions. |
| ProductInformation | |
|---|---|
| Format | AffinityPurified |
| Control |
|
| Presentation | Purifiedrabbitpolyclonalinbuffercontaining0.1MTris-Glycine(pH7.4),150mMNaClwith0.05%sodiumazide. |
| StorageandShippingInformation | |
|---|---|
| StorageConditions | Stablefor1yearat2-8°Cfromdateofreceipt. |
| BIOLOGicalInformation | |
|---|---|
| Immunogen | KLH-conjugatedlinearpeptidecorrespondingtotheC-terminusofratGRIP-1. |
| Epitope | C-terminus |
| Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. |
| Host | Rabbit |
| Specificity | ThisantibodyrecognizesGRIP-1attheC-terminus. |
| SpeciesReactivity |
|
| SpeciesReactivityNote | Demonstratedtoreactwithrat.Predictedtoreactwithhuman,mouse,andchimpanzeebasedon100%sequencehomology. |
| AntibodyType | PolyclonalAntibody |
| EntrezGeneNumber | |
| EntrezGeneSummary | Bindstotheliprin-alphaSVD2familyofproteinstomediatesynaptictargetingofAMPAreceptors;mayplayaroleinpresynapticandpostsynapticmaturation[RGD]. |
| GeneSymbol |
|
| PurificationMethod | AffinityPurfied |
| UniProtNumber | |
| UniProtSummary | FUNCTION:Mayplayaroleasalocalizedscaffoldfortheassemblyofamultiproteinsignalingcomplexandasmediatorofthetraffickingofitsbindingpartnersatspecificsubcellularlocationinneurons. SUBUNITSTRUCTURE:InteractswithEFNB1,EPHA7,EPHB2,EFNB3,KIF5A,KIF5C,KIF5BandtheC-terminaltailofPRLHR.FormsaternarycomplexwithGRIA2andCSPG4(Bysimilarity).CanformhomomultimersorheteromultimerswithGRIP2.InteractswithGRIA2,GRIA3,GRIPAP1/GRASP1,PPFIA1,PPFIA4,FRAS1,PLCD4,PTPRFandliprins-alpha.InteractswithSLC30A9(Bysimilarity). SUBCELLULARLOCATION:Cytoplasm.Endomembranesystem;Peripheralmembraneprotein.Celljunction›synapse›postsynapticcellmembrane.Celljunction›synapse›postsynapticcellmembrane›postsynapticdensity.Endoplasmicreticulummembrane;Peripheralmembraneprotein(Potential).Note:Membrane-associatedwithvesicles,peri-Golgicomplexesandendoplasmicreticulum.Enrichedinpost-synapticplasmamembraneandpost-synapticdensities. TISSUESPECIFICTY:Expressedinbrain,testisandretina.Inbrainhighlyexpressedintheolfactorybulb,cortexandhyppocampusandlowerlevelinthalamus,cerebellumandspinalcord.Inbrainitisfoundintheperikaryon,dendrites,dendriticshafts,dendriticspinesand,excitatoryandinhibitorysynapsesofneurons.Inretina,itismostabundantintheplexiformlayersthaninperikarya. DEVELOPMENTALSTAGE:DetectedinearlyembryonicstageasearlyasE15,graduallyincreasedthroughoutearlydevelopment,peakedatapproximatelybetweenpostnataldaysP6andP8,thenslightlydecreasedandremainedrelativelystableintheadult. DOMAIN:PDZ6mediatesinteractionwiththePDZrecognitionmotifofEFNB1andEPHB2andwiththeC-terminusofPPFIA1andPPFIA4.PDZ4andPDZ5mediateinteractionwithPRLHR(Bysimilarity).PDZ4andPDZ5mediateinteractionwiththeC-terminusofGRIA2andGRIA3.PDZ4,PDZ5andPDZ6mediatehomomultimers.PDZ7mediatesinteractionwithPDZdomainofGRASP1.PDZ7domainbindsCSPG4.PDZ6mediatesinteractionwiththeC-terminusofliprins-alpha.PDZ1,PDZ2andPDZ3mediateinteractionwiththePDZ-bindingmotifofFRAS1. SEQUENCESIMILARITIES:Contains7PDZ(DHR)domains. |
| MolecularWeight | ~121kDaobserved |
| PhysicochemicalInformation |
|---|
| Dimensions |
|---|
| MaterialsInformation |
|---|
| MaterialsInformation |
|---|
品牌介绍
密理博(Millipore)公司成立于1954年，总部位于美国麻省，在全世界设有47个办事处，为100多个国家提供产品和技术服务。目前全球雇员超过5800人，在美国、法国和日本等国家拥有7家大型生产工厂，主要生产过滤膜及膜过滤产品。20世纪80年代，密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构，并于2000年4月在上海浦东外高桥保税区建立了密理博（上海）贸易有限公司。为了更好地满足中国用户的需求，密理博中国主页于2006年11月向广大用户开放，介绍密理博中国有限公司的最新动态，力求为用户打造专业的产品与服务信息交流平台。
联络我们
