微孔/ABN100 |抗囊泡乙酰胆碱转运体（VAChT）抗体/ABN100/100µ；G
市场价：
¥6980.00
美元价：
4188.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Description | |
|---|---|
| CatalogueNumber | ABN100 |
| Description | Anti-VesicularAcetylcholineTransporter(VAChT)Antibody |
| AlternateNames |
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| BackgroundInformation | Acetylcholinemediatescholinergictransmissioninthecentralandperipheralnervoussystems,andisanimportantmodulatorofcognition,movement,andcardiovascularfunction,amongotherprocesses.Theeffectsofacetylcholineareregulatedbyitssynthesis,storage,andbreakdown,whichinvolvetherelatedenzymescholineacetyltransferase(ChAT),vesicularacetylcholinetransporter(VAChT),andacetylcholinesterase(AChE),respectively.VAChTisprimarilyfoundinthemembraneofpresynapticsecretoryvesicles.Itcontains12transmembranedomainsandasynaptic-vesicular–targetingsignallocatedontheintracellularC-terminaltail.TheprimaryfunctionofVAChTistoactivelytransportcytoplasmicACh,acrossanelectRochemicalgrADIent,intosynapticvesiclesthatreleaseAChuponcellstimulation.TheVAChTcanaffectcholinergicsignalingbyaffectingtherelativepoolsofAChsecretedtoactivatepostsynapticnicotinicandmuscarinicreceptors.VAChTisphosphorylatedonitsserine480residueintheC-terminaltailbyproteinkinaseC.Althoughthepreciseroleofthismodificationisstillunclear,previousstudiessuggestthatitmayaffectthelocalizationofVAChTtosynapticvesicles. |
| ProductInformation | |
|---|---|
| Format | AffinityPurified |
| Control |
|
| Presentation | Purifiedgoatpolyclonalinbuffercontaining0.1MTris-Glycine(pH7.4),150mMNaClwith0.05%sodiumazide. |
| StorageandShippingInformation | |
|---|---|
| StorageConditions | Stablefor1yearat2-8°Cfromdateofreceipt. |
| Applications | |
|---|---|
| Application | Anti-VesicularAcetylcholineTransporter(VAChT)AntibodydetectslevelofVesicularAcetylcholineTransporter(VAChT)&hasbeenpublished&validatedforuseinIHC,ELISA. |
| KeyApplications |
|
| ApplicationNotes | ImmunohistochemistryAnalysis:A1:1,000dilutionfromarepresentativelotdetectedVesicularAcetylcholineTransporter(VAChT)inratmidbraintissue. ELISAAnalysis:ArepresentativelotdetectedVesicularAcetylcholineTransporter(VAChT)inadirectELISAusingacorrespondingpeptide. |
| BIOLOGicalInformation | |
|---|---|
| Immunogen | KLH-conjugatedlinearpeptidecorrespondingtotheC-terminusofratVAChT. |
| Epitope | C-terminus |
| Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. |
| Host | Goat |
| Specificity | ThisantibodyrecognizestheC-terminusofVesicularAcetylcholineTransporter(VAChT). |
| SpeciesReactivity |
|
| SpeciesReactivityNote | DemonstratedtoreactwithRatandMouse.Otherhomologies:Human(95%sequencehomology). |
| AntibodyType | PolyclonalAntibody |
| EntrezGeneNumber | |
| GeneSymbol |
|
| PurificationMethod | AffinityPurfied |
| UniProtNumber | |
| MolecularWeight | 57kDacalculated |
| PhysicochemicalInformation |
|---|
| Dimensions |
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| MaterialsInformation |
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| MaterialsInformation |
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品牌介绍
密理博(Millipore)公司成立于1954年，总部位于美国麻省，在全世界设有47个办事处，为100多个国家提供产品和技术服务。目前全球雇员超过5800人，在美国、法国和日本等国家拥有7家大型生产工厂，主要生产过滤膜及膜过滤产品。20世纪80年代，密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构，并于2000年4月在上海浦东外高桥保税区建立了密理博（上海）贸易有限公司。为了更好地满足中国用户的需求，密理博中国主页于2006年11月向广大用户开放，介绍密理博中国有限公司的最新动态，力求为用户打造专业的产品与服务信息交流平台。
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