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Millipore/AB5905 | Anti-Vesicular Glutamate Transporter 1 Antibody/AB5905/50 µL
Millipore/AB5905 | Anti-Vesicular Glutamate Transporter 1 Antibody/AB5905/50 µL
市场价：
¥7600.00
美元价：
4560.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Description | |
|---|---|
| CatalogueNumber | AB5905 |
| BrandFamily | Chemicon® |
| TradeName |
|
| Description | Anti-VesicularGlutamateTransporter1Antibody |
| AlternateNames |
|
| BackgroundInformation | VGLUT1isexpressedinasubsetofglutamateneuronsandtransportsglutamateintonativesynapticvesiclesfromthebrain,exhibitingaconductanceforchloridethatisblockedbyglutamate.Vesicularglutamatetransporthasasubstantiallylowerapparentaffinitythantheplasmamembraneexcitatoryaminoacidtransporters.GlutamatetransportbyVGLUT1issaturatedwithaK(m)ofapproximately2mM,inthesamerangeastransportbysynapticvesicles.Finally,plasmamembraneglutamatetransportersrecognizebothaspartateandglutamateassubstrates,whereasVGLUT1doesnotrecognizeaspartate. |
| ProductInformation | |
|---|---|
| Format | Serum |
| Control |
|
| Presentation | GuineapigSerumin0.1%SodiumAzide. |
| StorageandShippingInformation | |
|---|---|
| StorageConditions | Maintainfor6monthsat-20°Cfromdateofshipment.Aliquottoavoidrepeatedfreezingandthawing.Formaximumrecoveryofproduct,centrifugetheoriginalvialafterthawingandpriortoremovingthecap. |
| BIOLOGicalInformation | |
|---|---|
| Immunogen | SyntheticpeptidefromratVGLUT1proteinwithnooverlaptoVGLUT2.TheimmunogenisavailableasAG208. |
| Concentration | Variable |
| Host | GuineaPig |
| Specificity | RecognizesVesicularGlutamateTransporter1(VGLUT1,BNPI{BrainspecificNa+dependentinorganicphosphatecotransporter}).Theantiserumhasbeentestedontissuesectionsfromtheratcentralnervoussystem(CNS)usingimmunofluorescencehistochemistry.Theantiserummainlylabelsnervefibersandterminals.VGLUT1isanexcellentMarkerforglutamatergicnerveterminals.ThestainingpatternforthestainingobtainedwiththeVGLUT1antiserumcorrespondstothepatterndescribedusingotherantiseratoVGLUT1(Bellocchioetal.,1998;Fremeauetal.,2001;Fujiyamaetal.,2001;Sakata-Hagaetal.,2001;Tongetal.,2001;Kanekoetal.2002;Varoquietal.,2002).PreabsorptionoftheVGLUT1antiserumwithimmunogenpeptideeliminatesallimmunostaining. |
| SpeciesReactivity |
|
| AntibodyType | PolyclonalAntibody |
| EntrezGeneNumber | |
| EntrezGeneSummary | aNa(+)-dependentinorganicphosphatecotransporter. |
| GeneSymbol |
|
| PurificationMethod | Unpurified |
| UniProtNumber | |
| UniProtSummary | FUNCTION:SwissProt:Mediatestheuptakeofglutamateintosynapticvesiclesatpresynapticnerveterminalsofexcitatoryneuralcells.Mayalsomediatethetransportofinorganicphosphate. SIZE:560aminoacids;61665Da[MWofunprocessedprecursor] SUBCELLULARLOCATION:Cytoplasmicvesicle,secretoryvesicle,synapticvesiclemembrane.Membrane;Multi-passmembraneprotein(Potential).Celljunction,synapse,synaptosome. TISSUESPECIFICITY:Expressedinthecerebellum,cerberalcortexandhippocampus.Isoform2isexpressedspecificallyinretina. SIMILARITY:Belongstothemajorfacilitatorsuperfamily.Sodium/anioncotransporterfamily.VGLUTsubfamily. |
| MolecularWeight | 62kDa |
| PhysicochemicalInformation |
|---|
| Dimensions |
|---|
| MaterialsInformation |
|---|
| MaterialsInformation |
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品牌介绍
密理博(Millipore)公司成立于1954年，总部位于美国麻省，在全世界设有47个办事处，为100多个国家提供产品和技术服务。目前全球雇员超过5800人，在美国、法国和日本等国家拥有7家大型生产工厂，主要生产过滤膜及膜过滤产品。20世纪80年代，密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构，并于2000年4月在上海浦东外高桥保税区建立了密理博（上海）贸易有限公司。为了更好地满足中国用户的需求，密理博中国主页于2006年11月向广大用户开放，介绍密理博中国有限公司的最新动态，力求为用户打造专业的产品与服务信息交流平台。
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