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当前位置: 首页 > 产品中心 > Functional_antibody > Millipore/AB5883 | Anti-Synapsin I Antibody, phosphoSer 603/AB5883/100 µL
商品详细Millipore/AB5883 | Anti-Synapsin I Antibody, phosphoSer 603/AB5883/100 µL
Millipore/AB5883 | Anti-Synapsin I Antibody, phosphoSer 603/AB5883/100 µL
Millipore/AB5883 | Anti-Synapsin I Antibody, phosphoSer 603/AB5883/100 µL
商品编号: AB5883
品牌: 密理博
市场价: ¥7180.00
美元价: 4308.00
产地: 美国(厂家直采)
公司:
产品分类: 功能性抗体
公司分类: Functional_antibody
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍
Description
CatalogueNumberAB5883
BrandFamilyChemicon®
TradeName
  • Chemicon
DescriptionAnti-SynapsinIAntibody,phosphoSer603
ProductInformation
FormatAffinityPurified
PresentationAffinitypurifiedimmunoglobulinpresentedasaliquidin10mMHEPES,pH7.5,with150mMNaCl,100μg/mLBSAand50%glycerol.
StorageandShippingInformation
StorageConditionsMaintainat-20°Cinundilutedforupto6monthsfromdateofreceipt.Avoidrepeatedfreeze/thawcycles.Donotstoreinaself-defrostingfreezer.
Applications
ApplicationAnti-SynapsinIAntibody,phosphoSer603detectslevelofSynapsinI&hasbeenpublished&validatedforuseinWB.
KeyApplications
  • WesternBlotting
ApplicationNotesWesternblot:1:1,000.Ratbrainlysateshowsa~78-80kDaband.

Optimalworkingdilutionsmustbedeterminedbytheenduser.
BIOLOGicalInformation
ImmunogenSyntheticpeptidecorrespondingtoaminoacidssurroundingthephosphoSer603ofratSynapsinI.Theimmunogensequenceisidenticalinhuman,mouseandXenopus.
EpitopephosphoSer603
HostRabbit
SpecificitySynapsinI,phosphoSer603.ThisisthesitephosphorylatedbyCalciumcalmodulinkinaseII.Theantibodyrecognizesthe~78kDSynapsinI,phosphoSer603protein.Immunolabelingisblockedbytheimmunogenpeptidebutnobythecorrespondingnon-phosphopeptide.
SpeciesReactivity
  • Rat
AntibodyTypePolyclonalAntibody
EntrezGeneNumber
EntrezGeneSummaryThisgeneisamemberofthesynapsingenefamily.Synapsinsencodeneuronalphosphoproteinswhichassociatewiththecytoplasmicsurfaceofsynapticvesicles.Familymembersarecharacterizedbycommonproteindomains,andtheyareimplicatedinsynaptogenesisandthemodulationofneurotransmitterrelease,suggestingapotentialroleinseveralneuropsychiatricdiseases.Thismemberofthesynapsinfamilyplaysaroleinregulationofaxonogenesisandsynaptogenesis.Theproteinencodedservesasasubstrateforseveraldifferentproteinkinasesandphosphorylationmayfunctionintheregulationofthisproteininthenerveterminal.MutationsinthisgenemaybeassociatedwithX-linkeddisorderswithprimaryneuronaldegenerationsuchasRettsyndrome.Alternativelysplicedtranscriptvariantsencodingdifferentisoformshavebeenidentified.
GeneSymbol
  • SYN1
  • SYN1a
  • Synapsin-1
  • SYNI
  • SYN1b
Modifications
  • Phosphorylation
UniProtNumber
UniProtSummaryFUNCTION:SwissProt:P17600#Neuronalphosphoproteinthatcoatssynapticvesicles,bindstotheCytoskeleton,andisbelievedtofunctionintheregulationofneurotransmitterrelease.ThecomplexformedwithNOS1andCAPONproteinsisnecessaryforspecificnitric-oxidfunctionsatapresynapticlevel.
SIZE:705aminoacids;74111Da
SUBUNIT:Homodimer.InteractswithCAPON.FormsaternarycomplexwithNOS1(Bysimilarity).
SUBCELLULARLOCATION:Celljunction,synapse.
PTM:Substrateofatleastfourdifferentproteinkinases.Itisprobablethatphosphorylationplaysaroleintheregulationofsynapsin-1inthenerveterminal.PhosphorylateduponDNAdamage,probablybyATMorATR.
DISEASE:SwissProt:P17600#DefectsinSYN1areacauseofX-linkedrecessiveepilepsyassociatedwithvariablelearningdisABIlitiesandbehaviordisorders[MIM:300491].
SIMILARITY:SwissProt:P17600##Belongstothesynapsinfamily.
PhysicochemicalInformation
Dimensions
MaterialsInformation
MaterialsInformation
品牌介绍
密理博(Millipore)公司成立于1954年,总部位于美国麻省,在全世界设有47个办事处,为100多个国家提供产品和技术服务。目前全球雇员超过5800人,在美国、法国和日本等国家拥有7家大型生产工厂,主要生产过滤膜及膜过滤产品。20世纪80年代,密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构,并于2000年4月在上海浦东外高桥保税区建立了密理博(上海)贸易有限公司。为了更好地满足中国用户的需求,密理博中国主页于2006年11月向广大用户开放,介绍密理博中国有限公司的最新动态,力求为用户打造专业的产品与服务信息交流平台。