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当前位置: 首页 > 产品中心 > Functional_antibody > Millipore/AB5852 |抗SHANK1a抗体,NT/AB5852/100µ;G
商品详细Millipore/AB5852 |抗SHANK1a抗体,NT/AB5852/100µ;G
Millipore/AB5852 |抗SHANK1a抗体,NT/AB5852/100µ;G
Millipore/AB5852 |抗SHANK1a抗体,NT/AB5852/100µ;G
商品编号: AB5852
品牌: 密理博
市场价: ¥6980.00
美元价: 4188.00
产地: 美国(厂家直采)
公司:
产品分类: 功能性抗体
公司分类: Functional_antibody
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍
Description
CatalogueNumberAB5852
BrandFamilyChemicon®
TradeName
  • Chemicon
DescriptionAnti-SHANK1aAntibody,NT
BackgroundInformationShankisanovelfamilyofpostsynapticdensityproteins(PSD)thatbindtoPDS-95-associatedproteinGKAP.ItsputativefunctionistoactasascaffoldproteininthePSDtocross-linkNMDAreceptors/PSD-95complexesandcouplethemtoregulatorsoftheactinCytoskeleton.Shank1aisasplicevariantofShank1.
ProductInformation
FormatPurified
PresentationPurifiedimmunoglobulin.LiquidinPBScontaining0.02%sodiumazide.
StorageandShippingInformation
StorageConditionsMaintainat-20°Cinundilutedaliquotsforupto12monthsafterdateofreceipt.Avoidrepeatedfreeze/thawcycles.
Applications
ApplicationAnti-SHANK1aAntibody,N-terminusisanantibodyagainstSHANK1aforuseinWB.
KeyApplications
  • WesternBlotting
ApplicationNotesWesternblotting:1:500-1:1,000

Optimalworkingdilutionsmustbedeterminedbytheenduser.
BIOLOGicalInformation
ImmunogenSyntheticpeptidecorrespondingtotheN-terminusofratShank1a.
EpitopeN-terminus
HostRabbit
SpecificityRecognizesShank1a,N-terminal.
SpeciesReactivity
  • Rat
AntibodyTypePolyclonalAntibody
EntrezGeneNumber
GeneSymbol
  • SHANK1
  • SSTRIP
  • SPANK-1
  • Shank1
  • synamon
UniProtNumber
UniProtSummaryFUNCTION:SwissProt:Q9Y566#Seemstobeanadapterproteininthepostsynapticdensity(PSD)ofexcitatorysynapsesthatinterconnectsreceptorsofthepostsynapticmembraneincludingNMDA-typeandmetabotropicglutamatereceptorsviacomplexeswithGKAP/PSD-95andHomer,respectively,andtheactin-basedcytoskeleton.Mayplayaroleinthestructuralandfunctionalorganizationofthedendriticspineandsynapticjunction.
SIZE:2161aminoacids;225021Da
SUBUNIT:MayhomomultimerizeviaitsSAMdomain(Bysimilarity).InteractswiththeC-terminusofSSTR2viathePDZdomain.InteractswithIGSF9,SHARPIN,SPTAN1,HOMER1andDLGAP1/GKAPisoforms1and2(Bysimilarity).PartofacomplexwithDLG4/PSD-95andDLGAP1/GKAP(Bysimilarity).InteractswithBAIAP2.
SUBCELLULARLOCATION:Cytoplasm(Bysimilarity).Celljunction,synapse,postsynapticcellmembrane,postsynapticdensity(Bysimilarity).Celljunction,synapse(Bysimilarity).Note=Postsynapticdensityofneuronalcells(Bysimilarity).TISSUESPECIFICITY:Expressedinbrainparticularlyintheamygdala,hippocampus,substantianigraandthalamus.Isoform2seemstobeexpressedubiquitously.
SIMILARITY:SwissProt:Q9Y566##BelongstotheSHANKfamily.&Contains6ANKrepeats.&Contains1PDZ(DHR)domain.&Contains1SAM(sterilealphamotif)domain.&Contains1SH3domain.
PhysicochemicalInformation
Dimensions
MaterialsInformation
MaterialsInformation
品牌介绍
密理博(Millipore)公司成立于1954年,总部位于美国麻省,在全世界设有47个办事处,为100多个国家提供产品和技术服务。目前全球雇员超过5800人,在美国、法国和日本等国家拥有7家大型生产工厂,主要生产过滤膜及膜过滤产品。20世纪80年代,密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构,并于2000年4月在上海浦东外高桥保税区建立了密理博(上海)贸易有限公司。为了更好地满足中国用户的需求,密理博中国主页于2006年11月向广大用户开放,介绍密理博中国有限公司的最新动态,力求为用户打造专业的产品与服务信息交流平台。