Millipore/AB5852 |抗SHANK1a抗体,NT/AB5852/100µ;G
市场价:
¥6980.00
美元价:
4188.00
产品分类:
功能性抗体
公司分类:
Functional_antibody
联系Q Q:
3392242852
电话号码:
4000-520-616
电子邮箱:
info@ebiomall.com
商品介绍
Description | |
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CatalogueNumber | AB5852 |
BrandFamily | Chemicon® |
TradeName |
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Description | Anti-SHANK1aAntibody,NT |
BackgroundInformation | Shankisanovelfamilyofpostsynapticdensityproteins(PSD)thatbindtoPDS-95-associatedproteinGKAP.ItsputativefunctionistoactasascaffoldproteininthePSDtocross-linkNMDAreceptors/PSD-95complexesandcouplethemtoregulatorsoftheactinCytoskeleton.Shank1aisasplicevariantofShank1. |
ProductInformation | |
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Format | Purified |
Presentation | Purifiedimmunoglobulin.LiquidinPBScontaining0.02%sodiumazide. |
StorageandShippingInformation | |
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StorageConditions | Maintainat-20°Cinundilutedaliquotsforupto12monthsafterdateofreceipt.Avoidrepeatedfreeze/thawcycles. |
BIOLOGicalInformation | |
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Immunogen | SyntheticpeptidecorrespondingtotheN-terminusofratShank1a. |
Epitope | N-terminus |
Host | Rabbit |
Specificity | RecognizesShank1a,N-terminal. |
SpeciesReactivity |
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AntibodyType | PolyclonalAntibody |
EntrezGeneNumber | |
GeneSymbol |
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UniProtNumber | |
UniProtSummary | FUNCTION:SwissProt:Q9Y566#Seemstobeanadapterproteininthepostsynapticdensity(PSD)ofexcitatorysynapsesthatinterconnectsreceptorsofthepostsynapticmembraneincludingNMDA-typeandmetabotropicglutamatereceptorsviacomplexeswithGKAP/PSD-95andHomer,respectively,andtheactin-basedcytoskeleton.Mayplayaroleinthestructuralandfunctionalorganizationofthedendriticspineandsynapticjunction. SIZE:2161aminoacids;225021Da SUBUNIT:MayhomomultimerizeviaitsSAMdomain(Bysimilarity).InteractswiththeC-terminusofSSTR2viathePDZdomain.InteractswithIGSF9,SHARPIN,SPTAN1,HOMER1andDLGAP1/GKAPisoforms1and2(Bysimilarity).PartofacomplexwithDLG4/PSD-95andDLGAP1/GKAP(Bysimilarity).InteractswithBAIAP2. SUBCELLULARLOCATION:Cytoplasm(Bysimilarity).Celljunction,synapse,postsynapticcellmembrane,postsynapticdensity(Bysimilarity).Celljunction,synapse(Bysimilarity).Note=Postsynapticdensityofneuronalcells(Bysimilarity).TISSUESPECIFICITY:Expressedinbrainparticularlyintheamygdala,hippocampus,substantianigraandthalamus.Isoform2seemstobeexpressedubiquitously. SIMILARITY:SwissProt:Q9Y566##BelongstotheSHANKfamily.&Contains6ANKrepeats.&Contains1PDZ(DHR)domain.&Contains1SAM(sterilealphamotif)domain.&Contains1SH3domain. |
PhysicochemicalInformation |
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Dimensions |
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MaterialsInformation |
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MaterialsInformation |
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品牌介绍
密理博(Millipore)公司成立于1954年,总部位于美国麻省,在全世界设有47个办事处,为100多个国家提供产品和技术服务。目前全球雇员超过5800人,在美国、法国和日本等国家拥有7家大型生产工厂,主要生产过滤膜及膜过滤产品。20世纪80年代,密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构,并于2000年4月在上海浦东外高桥保税区建立了密理博(上海)贸易有限公司。为了更好地满足中国用户的需求,密理博中国主页于2006年11月向广大用户开放,介绍密理博中国有限公司的最新动态,力求为用户打造专业的产品与服务信息交流平台。
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