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Millipore/AB5820-200UL | Anti-Syntaxin 1 Antibody/AB5820-200UL/200 µL
Millipore/AB5820-200UL | Anti-Syntaxin 1 Antibody/AB5820-200UL/200 µL
商品编号：
AB5820-200UL
品牌：
密理博
市场价：
¥12540.00
美元价：
7524.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Description | |
|---|---|
| CatalogueNumber | AB5820-200UL |
| BrandFamily | Chemicon® |
| TradeName |
|
| Description | Anti-Syntaxin1Antibody |
| ProductInformation | |
|---|---|
| Format | AffinityPurified |
| Control |
|
| Presentation | Affinitypurifiedimmunoglobulin.Lyophilizedfromphosphatebufferedsaline,pH7.4,containing1%BSA,and0.025%sodiumazideasapreservative.Reconstitutewith200μLofsteriledeionizedwater.Centrifugeantibodypreparationbeforeuse(10,000xgfor5min). |
| StorageandShippingInformation | |
|---|---|
| StorageConditions | Maintainlyophilizedmaterialat-20°Cforupto12monthsafterdateofreceipt.Afterreconstitutionmaintainat-20°Cinundilutedaliquotsforupto6months.Avoidrepeatedfreeze/thawcycles. |
| Applications | |
|---|---|
| Application | DetectSyntaxin1usingthisAnti-Syntaxin1AntibodyvalidatedforuseinWB,IH. |
| KeyApplications |
|
| ApplicationNotes | Westernblot:1:1000usingECLonratbrainmembranes. Immunohistochemistryonratbrainsections:AB5820isdirectedagainstanintracellularepitope.Thus,aprocedureincludingpermeABIlizationofcellswith0.2%TritonX100isrecommended.Itisrecommendedthatyoustartwithaworkingconcentrationof30μg/mL(1:33). DilutionsshouldbemadeusingacarrierproteinsuchasBSA(1-3%) Optimalworkingdilutionsmustbedeterminedbytheenduser. |
| BIOLOGicalInformation | |
|---|---|
| Immunogen | GSTfusionproteincorrespondingtoacytoplasmicpartofratSyntaxin1A(AccessionnumberP32851)(Bennetetal.1992;Inoue&Akagawa1992). |
| Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. |
| Host | Rabbit |
| Specificity | RecognizesSyntaxin1AandSyntaxin1B.Theepitopedoesnotsharehomologywithanyotherknownproteins. |
| SpeciesReactivity |
|
| AntibodyType | PolyclonalAntibody |
| EntrezGeneNumber | |
| EntrezGeneSummary | Synapticvesiclesstoreneurotransmittersthatarereleasedduringcalcium-regulatedexocytosis.Thespecificityofneurotransmitterreleaserequiresthelocalizationofbothsynapticvesiclesandcalciumchannelstothepresynapticactivezone.Syntaxinsfunctioninthisvesiclefusionprocess.SyntaxinsalsoserveasasubstrateforbotulinumneurotoxintypeC,ametalloproteasethatblocksexocytosisandhashighaffinityforamolecularcomplexthatincludesthealpha-latrotoxinreceptor(MIM600565)whichproducesexplosiveexocytosis(Zhangetal.,1995[PubMed7622072]).[suppliedbyOMIM] |
| GeneSymbol |
|
| UniProtNumber | |
| UniProtSummary | FUNCTION:SwissProt:Q16623#Potentiallyinvolvedindockingofsynapticvesiclesatpresynapticactivezones.Mayplayacriticalroleinneurotransmitterexocytosis. SIZE:288aminoacids;33023Da SUBUNIT:PartoftheSNAREcorecomplexcontainingSNAP25,VAMP2andSTX1A.ThiscomplexbindstoCPLX1.BindsSYTL4andSTXBP6.FoundinaternarycomplexwithSTX1AandSNAP25(Bysimilarity).FoundinacomplexwithVAMP8andSNAP23.InteractswithVAPAandSYBU. SUBCELLULARLOCATION:Cellmembrane;Single-passtypeIVmembraneprotein.&Isoform2:Secreted(Probable). TISSUESPECIFICITY:Isoform1ishighlyexpressedinembryonicspinalchordandgangliaandinadultcerebellumandcerebralcortex.Isoform2isexpressedinheart,liver,fat,skeletalmuscle,kidneyandbrain. DISEASE:SwissProt:Q16623#HaploinsufficiencyofSTX1Amaybethecauseofcertaincardiovascularandmusculo-skeletalabnormalitiesobservedinWilliams-Beurensyndrome(WBS),araredevelopmentaldisorder.Itisacontiguousgenedeletionsyndromeinvolvinggenesfromchromosomeband7q11.23. SIMILARITY:SwissProt:Q16623##Belongstothesyntaxinfamily.&Contains1t-SNAREcoiled-coilhomologydomain. |
| PhysicochemicalInformation |
|---|
| Dimensions |
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| MaterialsInformation |
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| MaterialsInformation |
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品牌介绍
密理博(Millipore)公司成立于1954年，总部位于美国麻省，在全世界设有47个办事处，为100多个国家提供产品和技术服务。目前全球雇员超过5800人，在美国、法国和日本等国家拥有7家大型生产工厂，主要生产过滤膜及膜过滤产品。20世纪80年代，密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构，并于2000年4月在上海浦东外高桥保税区建立了密理博（上海）贸易有限公司。为了更好地满足中国用户的需求，密理博中国主页于2006年11月向广大用户开放，介绍密理博中国有限公司的最新动态，力求为用户打造专业的产品与服务信息交流平台。
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