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Millipore/AB5464 | Anti-Synuclein Antibody, pan/AB5464/50 µL
Millipore/AB5464 | Anti-Synuclein Antibody, pan/AB5464/50 µL
市场价：
¥7800.00
美元价：
4680.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Description | |
|---|---|
| CatalogueNumber | AB5464 |
| BrandFamily | Chemicon® |
| TradeName |
|
| Description | Anti-SynucleinAntibody,pan |
| ProductInformation | |
|---|---|
| Format | Serum |
| Presentation | Rabbitserum.Lyophilized.Containsnopreservative.Reconstitutewith50μLofsteriledistilledwater.Centrifugeifnecessarytoremoveanyresidue. |
| StorageandShippingInformation | |
|---|---|
| StorageConditions | Maintainlyophilizedmaterialat-20°Cto-70°Cforupto6months.Afterreconstitutionmaintainfrozenat-20°Cinundilutedaliquotsforupto6months.Avoidrepeatedfreeze/thawcycles. |
| BIOLOGicalInformation | |
|---|---|
| Immunogen | Peptidecorrespondingtotheaminoacids11-26ofhumana,b,andg(82%)-synucleinprotein.Thepeptidewaschosensothattheantibodywouldrecognizeallthreeformsofsynuclein. |
| Host | Rabbit |
| Specificity | Pansynuclein.Initialtestingbyimmunohistochemistryindicatesthattheantibodystainingpatternoverlapsalpha,beta,andgamma-synucleinmaps. |
| SpeciesReactivity |
|
| AntibodyType | PolyclonalAntibody |
| EntrezGeneNumber | |
| EntrezGeneSummary | Theproteinencodedbythisgeneishighlyhomologoustoalpha-synuclein.TheseproteinsareabundantlyexpressedinthebrainandputativelyinhibitphospholipaseD2selectively.Theencodedprotein,whichmayplayaroleinneuronalplasticity,isabundantinneurofibrillarylesionsofpatientswithAlzheimerdisease.Thisproteinhasbeenshowntobehighlyexpressedinthesubstantianigraofthebrain,aregionofneuronaldegenerationinpatientswithParkinsondisease;however,nodirectrelationtoParkinsondiseasehasbeenestablished.Twotranscriptvariantsencodingthesameproteinhavebeenfoundforthisgene. |
| GeneSymbol |
|
| UniProtNumber | |
| UniProtSummary | FUNCTION:SwissProt:Q16143#Non-amyloidcomponentofsenileplaquesfoundinAlzheimerdisease.CouldactasaregulatorofSNCAaggregationprocess.Protectsneuronsfromstaurosporineand6hydroxydopamine(6OHDA)-stimulatedcaspaseactivationinap53-dependentmanner.ContributestorestoretheSNCAanti-apoptoticfunctionabolishedby6OHDA.NotfoundintheLewybodiesassociatedwithParkinsondisease. SIZE:134aminoacids;14288Da SUBCELLULARLOCATION:Cytoplasm. TISSUESPECIFICITY:Expressedpredominantlyinbrain;concentratedinpresynapticnerveterminals. PTM:Phosphorylated.PhosphorylationbyG-proteincoupledreceptorkinases(GRK)ismoreefficientthanphosphorylationbyCK1,CK2andCaM-kinaseII. DISEASE:SwissProt:Q16143#Brainironaccumulationtype1(NBIA1,alsocalledHallervorden-Spatzsyndrome),arareneuroaxonaldystrophy,ishistologicallycharacterizedbyaxonalspheroids,irondeposition,Lewybody(LB)-likeintraneuronalinclusions,glialinclusionsandneurofibrillarytangles.SNCBisfoundinspheroidsbutnotininclusions. SIMILARITY:SwissProt:Q16143##Belongstothesynucleinfamily. |
| PhysicochemicalInformation |
|---|
| Dimensions |
|---|
| MaterialsInformation |
|---|
| MaterialsInformation |
|---|
品牌介绍
密理博(Millipore)公司成立于1954年，总部位于美国麻省，在全世界设有47个办事处，为100多个国家提供产品和技术服务。目前全球雇员超过5800人，在美国、法国和日本等国家拥有7家大型生产工厂，主要生产过滤膜及膜过滤产品。20世纪80年代，密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构，并于2000年4月在上海浦东外高桥保税区建立了密理博（上海）贸易有限公司。为了更好地满足中国用户的需求，密理博中国主页于2006年11月向广大用户开放，介绍密理博中国有限公司的最新动态，力求为用户打造专业的产品与服务信息交流平台。
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