Millipore/AB5388 |抗Synfilin-1抗体，a.a.829-847/AB5388/50µ；L
市场价：
¥6580.00
美元价：
3948.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Description | |
|---|---|
| CatalogueNumber | AB5388 |
| BrandFamily | Chemicon® |
| TradeName |
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| Description | Anti-Synphilin-1Antibody,a.a.829-847 |
| AlternateNames |
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| ProductInformation | |
|---|---|
| Format | Serum |
| Presentation | Rabbitserum.Lyophilized.Containsnopreservative.Reconstitutewith50μLofsteriledistilledwater.Centrifugeifnecessarytoremoveanyresidue. |
| StorageandShippingInformation | |
|---|---|
| StorageConditions | Maintainlyophilizedmaterialat-20°Cto-70°Cforupto6months.Afterreconstitutionmaintainfrozenat-20°Cinundilutedaliquotsforupto6months.Avoidrepeatedfreeze/thawcycles. |
| BIOLOGicalInformation | |
|---|---|
| Immunogen | Asyntheticpeptidefromhumansynphilin-1(aminoacids829-847). |
| Epitope | a.a.829-847 |
| Host | Rabbit |
| Specificity | Synphilin-1.Immunohistochemicalanalysisofhumanbrainindicatesahighlevelofspecificity.Peptidesequenceusedshows88%sequencehomologywithmousesynphilin-1butmousehasnotbeentestedforreactivity. |
| SpeciesReactivity |
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| AntibodyType | PolyclonalAntibody |
| EntrezGeneNumber | |
| EntrezGeneSummary | Thisgeneencodesaproteincontainingseveralprotein-proteininteractiondomains,includingankyrin-likerepeats,acoiled-coildomain,andanATP/GTP-bindingmotif.Theencodedproteininteractswithalpha-synucleininneuronaltissueandmayplayaroleintheformationofcytoplasmicinclusionsandneurodegeneration.AmutationinthisgenehasbeenassociatedwithParkinson"sdisease.Alternativelysplicedtranscriptvariantsencodingdifferentisoformsofthisgenehavebeendescribed,buttheirfull-lengthnaturehasyettobedetermined. |
| GeneSymbol |
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| UniProtNumber | |
| UniProtSummary | SIZE:919aminoacids;100381Da SUBUNIT:AssociateswithSNCA,RNF19AANDPARK2. TISSUESPECIFICITY:Widelyexpressed,withhighestlevelsinbrain,heartandplacenta. PTM:Ubiquitinated;mediatedbySIAH1orRNF19AandleADIngtoitssubsequentproteasomaldegradation. DISEASE:SwissProt:Q9Y6H5#DefectsinSNCAIPareacauseofParkinsondisease(PD)[MIM:168600].PDisacomplex,multifactorialdisorderthattypicallymanifestsaftertheageof50years,althoughearly-onsetcases(before50years)areknown.PDgenerallyarisesasasporadicconditionbutisoccasionallyinheritedasasimplemendeliantrait.AlthoughsporadicandfamilialPDareverysimilar,inheritedformsofthediseaseusuallybeginatearlieragesandareassociatedwithatypicalclinicalfeatures.PDischaracterizedbybradykinesia,restingtremor,muscularrigidityandposturalinstABIlity,aswellasbyaclinicallysignificantresponsetotreatmentwithlevodopa.ThepathologyinvolvesthelossofdopaminergicneuronsinthesubstantianigraandthepresenceofLewybodies(intraneuronalaccumulationsofaggregatedproteins),insurvivingneuronsinvariousareasofthebrain. SIMILARITY:SwissProt:Q9Y6H5##Contains6ANKrepeats. MISCELLANEOUS:ConstructsencodingportionsofSNCAandSNCAIPco-transfectedinmammaliancellspromotecytosolicinclusionsresemblingtheLewybodiesofParkinsondisease.CoexpressionofSNCA,SNCAIP,andPARK2resultintheformationofLewybody-likeubiquitin-positivecytosolicinclusions.FamilialmutationsinPARK2disrupttheubiquitinationofSNCAIPandtheformationoftheubiquitin-positiveinclusions.TheseresultsprovideamolecularbasisfortheubiquitinationofLewybody-associatedproteinsandlinkPARK2andSNCAinacommonpathogenicmechanismthroughtheirinteractionwithSNCAIP. |
| PhysicochemicalInformation |
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| Dimensions |
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| MaterialsInformation |
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| MaterialsInformation |
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品牌介绍
密理博(Millipore)公司成立于1954年，总部位于美国麻省，在全世界设有47个办事处，为100多个国家提供产品和技术服务。目前全球雇员超过5800人，在美国、法国和日本等国家拥有7家大型生产工厂，主要生产过滤膜及膜过滤产品。20世纪80年代，密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构，并于2000年4月在上海浦东外高桥保税区建立了密理博（上海）贸易有限公司。为了更好地满足中国用户的需求，密理博中国主页于2006年11月向广大用户开放，介绍密理博中国有限公司的最新动态，力求为用户打造专业的产品与服务信息交流平台。
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