微孔/AB5038 |抗突触核蛋白α抗体/AB5038/50µ；L
市场价：
¥7400.00
美元价：
4440.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Description | |
|---|---|
| CatalogueNumber | AB5038 |
| Replaces | 04-1053 |
| BrandFamily | Chemicon® |
| TradeName |
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| Description | Anti-SynucleinαAntibody |
| AlternateNames |
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| BackgroundInformation | alpha-Synucleinisasmall(140aminoacid)cytoplasmicproteinofunclearfunctionthatisenrichedinpresynapticterminalsandistheprecursorproteinofanonamyloidbetacomponentofsenileplaquesinAlzeheimer"sDisease(AD).α-Synucleinislocatedpredominantlyinthepresynapticnerveterminalsinthebrainbutisalsofoundinlowconcentrationsinalltissuesexceptliver.Recentstudieshaveshownthatabnormalaggregationandaccumulationofsynapticproteins,includingα-SynucleinmightbeassociatedwithplaqueformationinADandseemstobeamajorcomponentofLewybodiesindementiawithLewybodies(DLB).IthasalsobeenidentifiedintheGlialCytoplasmicInclusions(GCIs)foundinMultipleSystemAtrophy(MSA). |
| ProductInformation | |
|---|---|
| Format | Serum |
| Control |
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| Presentation | Rabbitpolyclonalserumlyophilized,nopreservatives.Reconstitutewith50μLofsteriledistilledwater.Centrifugetoremoveanyresidue. |
| StorageandShippingInformation | |
|---|---|
| StorageConditions | Stablefor1yearat-20ºCfromdateofreceipt. |
| BIOLOGicalInformation | |
|---|---|
| Immunogen | Humanalpha-synucleinresidue111-131coupledtoKLH. |
| Epitope | a.a.111-131 |
| Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. |
| Host | Rabbit |
| Specificity | Alpha-synuclein.Theimmunizingpeptidewaschosentoreducecross-reactivityofAB5038withβ-synucleintoaminimum.ImmunohistochemicalandWesternblotanalysisofhumanbrainindicatesahighlevelofspecificity. |
| SpeciesReactivity |
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| SpeciesReactivityNote | Humanandrat.Hasnotbeentestedonotherspecies. |
| AntibodyType | PolyclonalAntibody |
| EntrezGeneNumber | |
| EntrezGeneSummary | Alpha-synucleinisamemberofthesynucleinfamily,whichalsoincludesbeta-andgamma-synuclein.Synucleinsareabundantlyexpressedinthebrainandalpha-andbeta-synucleininhibitphospholipaseD2selectively.SNCAmayservetointegratepresynapticsignalingandmembranetrafficking.DefectsinSNCAhavebeenimplicatedinthepathogenesisofParkinsondisease.SNCApeptidesareamajorcomponentofamyloidplaquesinthebrainsofpatientswithAlzheimer"sdisease.TwoalternativelysplicedtranscriptsofSNCAhavebeenidentified.Additionalsplicingmaybepresentbutthefull-lengthnatureofthesevariantshasnotbeendetermined. |
| GeneSymbol |
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| PurificationMethod | Unpurified |
| UniProtNumber | |
| UniProtSummary | FUNCTION:SwissProt:P37840#Maybeinvolvedintheregulationofdopaminereleaseandtransport.Solubleprotein,normallylocalizedprimarilyatthepresynapticregionofaxons,whichcanformfilamentousaggregatesthatarethemajornonamyloidcomponentofintracellularinclusionsinseveralneurodegenerativediseases(synucleinopathies).Inducesfibrillizationofmicrotubule-associatedproteintau.Reducesneuronalresponsivenesstovariousapoptoticstimuli,leADIngtoadecreasedcaspase3activation. SIZE:140aminoacids;14460Da SUBUNIT:Solublemonomerwhichcanformfilamentousaggregates.InteractswithUCHL1(Bysimilarity).InteractswithphospholipaseDandhistones. SUBCELLULARLOCATION:Cytoplasm.Membrane.Nucleus.Note=Membrane-boundindopaminergicneurons.Alsofoundinthenucleus. TISSUESPECIFICITY:Expressedprincipallyinbrainbutisalsoexpressedinlowconcentrationsinalltissuesexaminedexceptinliver.Concentratedinpresynapticnerveterminals. DOMAIN:SwissProt:P37840TheNACdomainisinvolvedinthefibrilformation.Themiddleregionformsthecoreofthefilaments.TheC-terminusmayregulateaggregationanddeterminethediameterofthefilaments. PTM:Phosphorylated,predominantlyonserineresidues.PhosphorylationbyCK1appearstooccuronresiduesdistinctfromtheresiduephosphorylatedbyotherkinases.PhosphorylationofSer-129isselectiveandextensiveinsynucleinopathylesions.Invitro,phosphorylationatSer-129promotedinsolublefibrilformation.PhosphorylatedonTyr-125byaPTK2B-dependentpathwayuponosmoticstress.&Hallmarklesionsofneurodegenerativesynucleinopathiescontainalpha-synucleinthatismodifiedbynitrationoftyrosineresiduesandpossIBLybydityrosinecross-linkingtogeneratedstableoligomers.&Ubiquitinated.Thepredominantconjugateisthediubiquitinatedform(Bysimilarity). DISEASE:SwissProt:P37840#DefectsinSNCAareacauseofautosomaldominantParkinsondisease1(PARK1)[MIM:168601,168600].Parkinsondisease(PD)isacomplex,multifactorialdisorderthattypicallymanifestsaftertheageof50years,althoughearly-onsetcases(before50years)areknown.PDgenerallyarisesasasporadicconditionbutisoccasionallyinheritedasasimplemendeliantrait.AlthoughsporadicandfamilialPDareverysimilar,inheritedformsofthediseaseusuallybeginatearlieragesandareassociatedwithatypicalclinicalfeatures.PDischaracterizedbybradykinesia,restingtremor,muscularrigidityandposturalinstABIlity,aswellasbyaclinicallysignificantresponsetotreatmentwithlevodopa.ThepathologyinvolvesthelossofdopaminergicneuronsinthesubstantianigraandthepresenceofLewybodies(intraneuronalaccumulationsofaggregatedproteins),insurvivingneuronsinvariousareasofthebrain.&DefectsinSNCAarethecauseofParkinsondisease4(PARK4)[MIM:605543,168600].&DefectsinSNCAarethecauseofLewybodydementia(DLB)[MIM:127750].DLBisaneurodegenerativedisorderclinicallycharacterizedbydementiaandparkinsonism,oftenwithfluctuatingcognitivefunction,visualhallucinations,falls,syncopalepisodes,andsensitivitytoneurolepticmedication.PresenceofLewybodiesaretheonlyessentialpathologicfeatures.&DepositionoffibrillaramyloidproteinsintraneuronallyasneurofibrillarytanglesischaracteristicofAlzheimerdisease(AD).SNCAisaminorproteinfoundwithinthesedeposits,butamajornonamyloidcomponent.&Brainironaccumulationtype1(NBIA1,alsocalledHallervorden-Spatzsyndrome),arareneuroaxonaldystrophy,ishistologicallycharacterizedbyaxonalspheroids,irondeposition,Lewybody(LB)-likeintraneuronalinclusions,glialinclusionsandneurofibrillarytangles.SNCAisfoundinLB-likeinclusions,glialinclusionsandspheroids. SIMILARITY:Belongstothesynucleinfamily. |
| MolecularWeight | ~14-19kDa |
| PhysicochemicalInformation |
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| Dimensions |
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| MaterialsInformation |
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| MaterialsInformation |
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品牌介绍
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