密理博/AB19021 |抗α-连环蛋白抗体/AB19021/50µ；L
市场价：
¥6780.00
美元价：
4068.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Description | |
|---|---|
| CatalogueNumber | AB19021 |
| BrandFamily | Chemicon® |
| TradeName |
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| Description | Anti-α-CateninAntibody |
| BackgroundInformation | Thecateninsarepolypeptidesthatbindtotheconservedcytoplasmictailofcadherinsandarerequiredforcadherinfunction(Gumbineretal.1993).a-cateninisa102kDaproteinthatisassociatedwiththecadherinindirectlythroughitsinteractionwithbeta-cateninandgamma-catenin(Fouquetetal.1992).beta-Cateninanditshomologplakoglobinassociatedirectlywiththecadherin(Butzetal.1994).Thus,thecell-celladherensjunctionisastructurecomposedofthetransmembranecadherin,whichisassociateddirectlywitheitherbeta-cateninorplakoglobin,whichinturnassoctiatesdirectlywithalpha-catenin.alpha-cateninthenmediatestheinteractionbetweenthecadherin-catenincomplexandtheactinCytoskeleton(Nagafuchietal.1994;Shahiduletal.1996).alpha-cateninhasbeencharacterizedasatumorsuppressor,suggestingthatitmayhavearegulatoryfunctioninregulationtoitsstructuralrole(Rudiger1998). |
| ProductInformation | |
|---|---|
| Format | Serum |
| Presentation | Serum.Liquidcontainingnopreservatives. |
| StorageandShippingInformation | |
|---|---|
| StorageConditions | Maintainfrozenat-20°Cinundilutedaliquotsforupto12months. |
| Applications | |
|---|---|
| Application | Detectα-CateninusingthisAnti-α-CateninAntibodyvalidatedforuseinELISA,IP,WB,IC,IH(P). |
| KeyApplications |
|
| ApplicationNotes | Westernblot Immunocytochemistry Immunohistochemistryonformalin-fixedparaffin-embeddedtissues*:1:250-1:500*requirespressurecookerantigenretrievalmethod(Nagafuchietal.1994). Immunoprecipitation ELISA Optimalworkingdilutionsmustbedeterminedbyenduser. |
| BIOLOGicalInformation | |
|---|---|
| Immunogen | RecombinantGST-fusionprotein(aminoterminal;576aminoacids) |
| Host | Rabbit |
| SpeciesReactivity |
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| AntibodyType | PolyclonalAntibody |
| EntrezGeneNumber | |
| GeneSymbol |
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| UniProtNumber | |
| UniProtSummary | FUNCTION:SwissProt:P35221#Associateswiththecytoplasmicdomainofavarietyofcadherins.Theassociationofcateninstocadherinsproducesacomplexwhichislinkedtotheactinfilamentnetwork,andwhichseemstobeofprimaryimportanceforcadherinscell-adhesionproperties.Mayplayacrucialroleincelldifferentiation. SIZE:906aminoacids;100071Da SUBUNIT:BindsMLLT4andF-actin(Bysimilarity).InteractsdirectlywithPSEN1andCTNNB1toformpartofthePSEN1/cadherin/cateninadhesioncomplex.InteractswithARHGAP21. SUBCELLULARLOCATION:Cytoplasm,cytoskeleton.Celljunction,adherensjunction;Cytoplasmicside.Celljunction;Cytoplasmicside.Note=Foundatcell-cellboundariesandprobablyatcell-matrixboundaries. TISSUESPECIFICITY:Expressedubiquitouslyinnormaltissues. PTM:Sumoylated. DISEASE:SwissProt:P35221#Abnormalitiesofalpha-cateninareinvolvedintheprocessofcancerinvasionandmetastasis. SIMILARITY:SwissProt:P35221##Belongstothevinculin/alpha-cateninfamily. |
| PhysicochemicalInformation |
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| Dimensions |
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| MaterialsInformation |
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| MaterialsInformation |
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品牌介绍
密理博(Millipore)公司成立于1954年，总部位于美国麻省，在全世界设有47个办事处，为100多个国家提供产品和技术服务。目前全球雇员超过5800人，在美国、法国和日本等国家拥有7家大型生产工厂，主要生产过滤膜及膜过滤产品。20世纪80年代，密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构，并于2000年4月在上海浦东外高桥保税区建立了密理博（上海）贸易有限公司。为了更好地满足中国用户的需求，密理博中国主页于2006年11月向广大用户开放，介绍密理博中国有限公司的最新动态，力求为用户打造专业的产品与服务信息交流平台。
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