Millipore/AB1762 | Anti-SNAP-25 Antibody/AB1762/50 µL
市场价：
¥5540.00
美元价：
3324.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Description | |
|---|---|
| CatalogueNumber | AB1762 |
| BrandFamily | Chemicon® |
| TradeName |
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| Description | Anti-SNAP-25Antibody |
| AlternateNames |
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| ProductInformation | |
|---|---|
| Format | Serum |
| Presentation | Liquidserumcontaining0.1%sodiumazide. |
| StorageandShippingInformation | |
|---|---|
| StorageConditions | Maintainat-20°Cinundilutedaliquotsforupto12months.Avoidrepeatedfreeze/thawcycles. |
| BIOLOGicalInformation | |
|---|---|
| Immunogen | AsyntheticpeptidefromtheC-terminalheptadeapeptideofmouseSNAP-25(correspondingtoresiduesCys+190-206:[C]RIDEANQRATKMLGSG). |
| Host | Rabbit |
| Specificity | SNAP-25(synaptosome-associatedproteinof25kDa)isaSNAP(solubleN-ethylmaleimide-sensitivefusion(NSF)attachmentprotein)receptor(SNARE-relatedprotein)whichistightlyassociatedwiththeplasmamembranebymeansofthepalmitoylationofaclustercysteinresidueswithitsstructure.NocrossreactivitywithSNAP-23isexpected. SNAP-25isspecificallycleavedclosetothecarboxylterminalbythebotulinumneurotoxins(BoNT)AandEwhichareknowntoinhibitneurotransmitterrelease.SimilarinhibitoryeffectsofBoNT/AandEhavebeenrecordedfornon-neuronalsecretorycells,suchasadrenalmedulla,andthisleadtotheidentificationofSNAP-25inSNARE-likecomplexesprecipitatedfromchromaffincells. |
| SpeciesReactivity |
|
| AntibodyType | PolyclonalAntibody |
| EntrezGeneNumber | |
| EntrezGeneSummary | SynapticvesiclemembranedockingandfusionismediatedbySNAREs(solubleN-ethylmaleimide-sensitivefactorattachmentproteinreceptors)locatedonthevesiclemembrane(v-SNAREs)andthetargetmembrane(t-SNAREs).Theassembledv-SNARE/t-SNAREcomplexconsistsofabundleoffourhelices,oneofwhichissuppliedbyv-SNAREandtheotherthreebyt-SNARE.Fort-SNAREsontheplasmamembrane,theproteinsyntaxinsuppliesonehelixandtheproteinencodedbythisgenecontributestheothertwo.Therefore,thisgeneproductisapresynapticplasmamembraneproteininvolvedintheregulationofneurotransmitterrelease.Twoalternativetranscriptvariantsencodingdifferentproteinisoformshavebeendescribedforthisgene. |
| GeneSymbol |
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| UniProtNumber | |
| UniProtSummary | FUNCTION:SwissProt:P60880#t-SNAREinvolvedinthemolecularregulationofneurotransmitterrelease.Mayplayanimportantroleinthesynapticfunctionofspecificneuronalsystems.Associateswithproteinsinvolvedinvesicledockingandmembranefusion. SIZE:206aminoacids;23315Da SUBUNIT:PartoftheSNAREcorecomplexcontainingSNAP25,VAMP2andSTX1A.ThiscomplexbindsCPLX1.InteractswithTRIM9,RIMS1,SNAP25BPandHGS.BindsSTXBP6.FoundinaternarycomplexwithSTX1AandVAMP8.FoundinacomplexcontainingSYT1,SV2Bandsyntaxin-1(Bysimilarity). TISSUESPECIFICITY:Neuronsoftheneocortex,hippocampus,piriformcortex,anteriorthalamicnuclei,pontinenuclei,andgranulecellsofthecerebellum. PTM:Palmitoylated(Bysimilarity). SIMILARITY:SwissProt:P60880##BelongstotheSNAP-25family.&Contains2t-SNAREcoiled-coilhomologydomains. |
| PhysicochemicalInformation |
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| Dimensions |
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| MaterialsInformation |
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| MaterialsInformation |
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品牌介绍
密理博(Millipore)公司成立于1954年，总部位于美国麻省，在全世界设有47个办事处，为100多个国家提供产品和技术服务。目前全球雇员超过5800人，在美国、法国和日本等国家拥有7家大型生产工厂，主要生产过滤膜及膜过滤产品。20世纪80年代，密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构，并于2000年4月在上海浦东外高桥保税区建立了密理博（上海）贸易有限公司。为了更好地满足中国用户的需求，密理博中国主页于2006年11月向广大用户开放，介绍密理博中国有限公司的最新动态，力求为用户打造专业的产品与服务信息交流平台。
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