密理博/07-300 |抗Cofilin 2抗体/07-300/200µ；G
市场价：
¥7400.00
美元价：
4440.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Description | |
|---|---|
| CatalogueNumber | 07-300 |
| BrandFamily | Upstate |
| TradeName |
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| Description | Anti-Cofilin2Antibody |
| ProductInformation | |
|---|---|
| Format | Purified |
| Presentation | 0.1MTris-glycine,pH7.4,0.15MNaCl,0.05%sodiumazidebeforetheadditionofglycerolto30% |
| StorageandShippingInformation | |
|---|---|
| StorageConditions | 2yearsat-20°C |
| Applications | |
|---|---|
| Application | ThisAnti-Cofilin2AntibodyisvalidatedforuseinWBforthedetectionofCofilin2. |
| KeyApplications |
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| BIOLOGicalInformation | |
|---|---|
| Immunogen | peptidecorrespondingtoaminoacids136-152(C-QVNGLDDIKDRSTLGEK)ofhumanCofilin2 |
| Host | Rabbit |
| Specificity | Cofilin2 |
| Isotype | IgG |
| SpeciesReactivity |
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| AntibodyType | PolyclonalAntibody |
| EntrezGeneNumber | |
| EntrezGeneSummary | Cofilinisawidelydistributedintracellularactin-modulatingproteinthatbindsanddepolymerizesfilamentousF-actinandinhibitsthepolymerizationofmonomericG-actininapH-dependentmanner.(Gillettetal.,1996[PubMed8800436]).Cofilin-2isamemberoftheACgroupofproteinsthatalsoincludescofilin-1(CFL1)anddestrin(DSTN;MIM609114),allofwhichregulateactin-filamentdynamics(Bamburgetal.,1999[PubMed10461190];MaciverandHussey,2002).TheCFL2geneencodesaskeletalmuscle-specificisoform(Vartiainenetal.,2002[PubMed11809832])localizedtothethinfilaments,whereitexertsitseffectonactin,inpartthroughinteractionswithtropomyosins(OnoandOno,2002[PubMed11901171]).[suppliedbyOMIM] |
| GeneSymbol |
|
| PurificationMethod | ProteinAchromatography |
| UniProtNumber | |
| UniProtSummary | FUNCTION:SwissProt:Q9Y281#ControlsreversIBLyactinpolymerizationanddepolymerizationinapH-sensitivemanner.IthastheABIlitytobindG-andF-actinina1:1ratioofcofilintoactin.Itisthemajorcomponentofintranuclearandcytoplasmicactinrods(Bysimilarity). SIZE:166aminoacids;18737Da SUBCELLULARLOCATION:Nucleusmatrix(Bysimilarity).Cytoplasm,Cytoskeleton(Bysimilarity). TISSUESPECIFICITY:IsoformCFL2bisexpressedpredominantlyinskeletalmuscleandheart,whileisoformCFL2aisexpressedinvarioustissues. PTM:ThephosphorylationofSer-24maypreventrecognitionofthenuclearlocalizationsignal. DISEASE:SwissProt:Q9Y281#DefectsinCFL2arethecauseofnemalinemyopathytype7(NEM7)[MIM:610687].Nemalinemyopathy(NEM)isaformofcongenitalmyopathycharacterizedbyabnormalthread-orrod-likestructuresinmusclefibersonhistologicexamination.Theclinicalphenotypeishighlyvariable,withdifferingageatonsetandseverity. SIMILARITY:SwissProt:Q9Y281##Belongstotheactin-bindingproteinsADFfamily.&Contains1ADF-Hdomain. |
| MolecularWeight | 21kDa |
| PhysicochemicalInformation |
|---|
| Dimensions |
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| MaterialsInformation |
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| MaterialsInformation |
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品牌介绍
密理博(Millipore)公司成立于1954年，总部位于美国麻省，在全世界设有47个办事处，为100多个国家提供产品和技术服务。目前全球雇员超过5800人，在美国、法国和日本等国家拥有7家大型生产工厂，主要生产过滤膜及膜过滤产品。20世纪80年代，密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构，并于2000年4月在上海浦东外高桥保税区建立了密理博（上海）贸易有限公司。为了更好地满足中国用户的需求，密理博中国主页于2006年11月向广大用户开放，介绍密理博中国有限公司的最新动态，力求为用户打造专业的产品与服务信息交流平台。
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