密理博/06-900 |抗SynGAP抗体/06-900/100&mu；G
市场价：
¥5960.00
美元价：
3576.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Description | |
|---|---|
| CatalogueNumber | 06-900 |
| Replaces | 04-1071 |
| BrandFamily | Upstate |
| TradeName |
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| Description | Anti-SynGAPAntibody |
| BackgroundInformation | Silentsynapses,orexcitatorysynapsesthatlackfunctional-amino-3-hydroxy-5-methyl-4-isoxazolepropionicacidreceptors(AMPARs),arethoughttobecriticalforregulationofneuronalcircuitsandsynapticplasticity.SynGAP,anexcitatorysynapse-specificRasGAP,regulatesAMPARtrafficking,silentsynapsenumber,andexcitatorysynaptictransmissioninhippocampalandcorticalculturedneurons.OverexpressionofSynGAPinneuronsresultsinaremarkabledepressionofAMPAR-mediatedminiatureexcitatorypostsynapticcurrents,asignificantreductioninsynapticAMPARsurfaceexpression,andadecreaseintheinsertionofAMPARsintotheplasmamembrane.SynaptictransmissionisincreasedinneuronsfromSynGAPknockoutmiceaswellasinneuronalculturestreatedwithSynGAPsmallinterferingRNA. |
| ProductInformation | |
|---|---|
| Format | Purified |
| Presentation | PurifiedinPBSwith0.05%NaN3and30%Glycerol |
| StorageandShippingInformation | |
|---|---|
| StorageConditions | Maintainat-20°Cinundilutedaliquotsforupto1yearafterdateofreceipt. |
| Applications | |
|---|---|
| Application | Anti-SynGAPAntibodydetectslevelofSynGAP&hasbeenpublished&validatedforuseinIC&WB. |
| KeyApplications |
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| ApplicationNotes | Immunocytochemistry:0.1µg/mLhasbeenreportedtoimmunostainSynGAPinneuronculturesfixedwith4%paraformaldehyde,4%sucroseandperme-ABIlizedwith0.1%TritonX-100(2). |
| BIOLOGicalInformation | |
|---|---|
| Immunogen | peptide(KRLLDAQRGSFPPWVQQTRV)correspondingtoaminoacids1274-1293ofratSynGAP-a |
| Host | Rabbit |
| Specificity | SynGAP |
| SpeciesReactivity |
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| AntibodyType | PolyclonalAntibody |
| EntrezGeneNumber | |
| GeneSymbol |
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| PurificationMethod | ProteinAPurfied |
| UniProtNumber | |
| UniProtSummary | FUNCTION:SwissProt:Q96PV0#MajorconstituentofthePSDessentialforpostsynapticsignaling.InhibitoryregulatoroftheRas-cAMPpathway.MemberoftheNMDARsignalingcomplexinexcitatorysynapses,itmayplayaroleinNMDAR-dependentcontrolofAMPARpotentiation,AMPARmembranetraffickingandsynapticplasticity.RegulatesAMPAR-mediatedminiatureexcitatorypostsynapticcurrents.Maybeinvolvedincertainformsofbraininjury,leADIngtolong-termlearningandmemorydeficits(Bysimilarity). SIZE:1343aminoacids;148284Da SUBUNIT:InteractsCAMK2AandCAMK2B(Bysimilarity).InteractswithMPDZ. PTM:PhosphorylatedbyCaM-kinaseII.DephosphorylateduponNMDAreceptoractivationorSYNGAP1/MPDZcomplexdisruption(Bysimilarity). SIMILARITY:SwissProt:Q96PV0##Contains1C2domain.&Contains1PHdomain.&Contains1Ras-GAPdomain. |
| PhysicochemicalInformation |
|---|
| Dimensions |
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| MaterialsInformation |
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| MaterialsInformation |
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品牌介绍
密理博(Millipore)公司成立于1954年，总部位于美国麻省，在全世界设有47个办事处，为100多个国家提供产品和技术服务。目前全球雇员超过5800人，在美国、法国和日本等国家拥有7家大型生产工厂，主要生产过滤膜及膜过滤产品。20世纪80年代，密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构，并于2000年4月在上海浦东外高桥保税区建立了密理博（上海）贸易有限公司。为了更好地满足中国用户的需求，密理博中国主页于2006年11月向广大用户开放，介绍密理博中国有限公司的最新动态，力求为用户打造专业的产品与服务信息交流平台。
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