密理博/06-852 |抗棘球蛋白/NeurabinⅡ抗体/06-852/200µ；G
市场价：
¥8020.00
美元价：
4812.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Description | |
|---|---|
| CatalogueNumber | 06-852 |
| BrandFamily | Upstate |
| TradeName |
|
| Description | Anti-Spinophilin/NeurABIn-IIAntibody |
| AlternateNames |
|
| BackgroundInformation | Spinophilin/neurabinIIisanactin-associatedscaffoldingproteinenrichedinthedendriticspinesofneurons. |
| ProductInformation | |
|---|---|
| Format | Purified |
| Control |
|
| Presentation | PurifiedrabbitpolyclonalIgGinbuffercontaining70%storagebuffer(0.014Mphosphatebuffer,pH7.6,0.175MNaCl,0.07%sodiumazide)and30%glycerol.Storeat-20°C. |
| StorageandShippingInformation | |
|---|---|
| StorageConditions | Stablefor1yearat-20ºCfromdateofreceipt. HandlingRecommendations: Uponreceipt,andpriortoremovingthecap,centrifugethevialandgentlymixthesolution.Aliquotintomicrocentrifugetubesandstoreat-20°C.Avoidrepeatedfreeze/thawcycles,whichmaydamageIgGandaffectproductperformance.Note:Variabilityinfreezertemperaturesbelow-20°Cmaycauseglycerolcontainingsolutionstobecomefrozenduringstorage. |
| BIOLOGicalInformation | |
|---|---|
| Immunogen | GSTfusionproteincorrespondingtoresidues286-390ofratbrainspinophilin/neurabin-II. |
| Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. |
| Host | Rabbit |
| Specificity | Specificforspinophilin,Mr120kDa.AlsorecognizesabandwhichissUSPectedtobeacleavageproductofspinophilin,Mr95kDa. |
| Isotype | IgG |
| SpeciesReactivity |
|
| SpeciesReactivityNote | Rat.Otherspeciesnotknown. |
| AntibodyType | PolyclonalAntibody |
| EntrezGeneNumber | |
| EntrezGeneSummary | Spinophilinisaregulatorysubunitofproteinphosphatase-1catalyticsubunit(PP1;seeMIM176875)andishighlyenrichedindendriticspines,specializedprotrusionsfromdendriticshaftsthatreceivemostoftheexcitatoryinputinthecentralnervoussystem(Allenetal.,1997[PubMed9275233]).[suppliedbyOMIM] |
| GeneSymbol |
|
| PurificationMethod | ProteinGPurified |
| UniProtNumber | |
| UniProtSummary | FUNCTION:SwissProt:Q96SB3#Seemstoactasascaffoldproteininmultiplesignalingpathways.Modulatesexcitatorysynaptictransmissionanddendriticspinemorphology.Bindstoactinfilaments(F-actin)andshowscross-linkingactivity.BindsalongthesidesoftheF-actin.MayplayanimportantroleinlinkingtheactinCytoskeletontotheplasmamembraneatthesynapticjunction.Believedtotargetproteinphosphatase1/PP1todendriticspines,whicharerichinF-actin,andregulatesitsspecificitytowardionchannelsandothersubstrates,suchasAMPA-typeandNMDA-typeglutamatereceptors.PlaysaroleinregulationofG-proteincoupledreceptorsignaling,includingdopamineD2receptorsandalpha-adrenergicreceptors.MayestablishasignalingcomplexfordopaminergicneurotransmissionthroughD2receptorsbylinkingreceptorsdownstreamsignalingmoleculesandtheactincytoskeleton.BindstoADRA1BandRGS2andmediatesregulationofADRA1Bsignaling.MayconfertoRacsignalingspecificitybybindingtoboth,RacGEFsandRaceffectorproteins.Probablyregulatesp70S6kinaseactivitybyformingacomplexwithTIAM1(Bysimilarity). SIZE:815aminoacids;89192Da SUBUNIT:PossIBLyexistsasanhomodimer,homotrimeroranhomotetramer.InteractswithF-actin,PPP1CA,neurabin-1,TGN38andD(2)dopaminereceptor.InteractswithRGS1,RGS2,RGS4,RGS19andADRA1B,ADRA2A,ADRA2B,ADRA2C,CDKN2A,PPP1R2,RASGFR1andTIAM1. SUBCELLULARLOCATION:Cytoplasm(Bysimilarity).Nucleus(Bysimilarity).Cellprojection,dendriticspine(Bysimilarity).Celljunction,synapse.Note=Enrichedatsynapseandcadherin-basedcell-celladhesionsites.Inneurons,bothcytosolicandmembrane-associated,andhighlyenrichedinthepost-synapticdensityapposedtoexitatorysynapses.ColocalizeswithPPP1R2atactin-richadherensjunctionsinepithelialcellsandindendriticspines(Bysimilarity). PTM:StimulationofD1(butnotD2)dopaminereceptorsinducesSer-94phosphorylation.DephosphorylationofSer-94ismediatedmainlybyPP1andtoalesserextentbyPP2A.PhosphorylationofspinophilindisruptsitsassociationwithF-actin,butdoesnotaffectitsbindingtoPP1(Bysimilarity). SIMILARITY:SwissProt:Q96SB3##Contains1PDZ(DHR)domain. |
| MolecularWeight | 120kDa |
| PhysicochemicalInformation |
|---|
| Dimensions |
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| MaterialsInformation |
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| MaterialsInformation |
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品牌介绍
密理博(Millipore)公司成立于1954年，总部位于美国麻省，在全世界设有47个办事处，为100多个国家提供产品和技术服务。目前全球雇员超过5800人，在美国、法国和日本等国家拥有7家大型生产工厂，主要生产过滤膜及膜过滤产品。20世纪80年代，密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构，并于2000年4月在上海浦东外高桥保税区建立了密理博（上海）贸易有限公司。为了更好地满足中国用户的需求，密理博中国主页于2006年11月向广大用户开放，介绍密理博中国有限公司的最新动态，力求为用户打造专业的产品与服务信息交流平台。
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