Millipore/MAB347 |抗生长相关蛋白43抗体，克隆9-1E12/MAB347/50µ；G
市场价：
¥0.00
美元价：
0.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Description | |
|---|---|
| CatalogueNumber | MAB347 |
| BrandFamily | Chemicon® |
| TradeName |
|
| Description | Anti-GrowthAssociatedProtein43Antibody,clone9-1E12 |
| AlternateNames |
|
| BackgroundInformation | GAP-43,acommonMarkerofdifferentiatingneurons,isexpressedatelevatedlevelsbydevelopingorregeneratingneuronsduringaxongrowth.WhileGAP-43isanintegralmembraneproteinassociatedwiththecytoplasmicsurfaceofaxonalgrowthcones(andsynapses),itisabsentfromdendriticgrowthcones.Inadultbrain,GAP-43isfoundinhighconcentrationinpresynapticareaswherememoryformationisthoughttooccur,suchasfrontalcortex,limbicsystemandhippocampus.PhosphorylationofGAP-43byPKC(atSer41onhuman,mouse,rat,andbovineGAP-43orSer42onchickenandXenopusGAP-43)isspecificallycorrelatedwithcertainformsofsynapticplasticity. |
| ProductInformation | |
|---|---|
| Format | Purified |
| Control |
|
| Presentation | ProteinAPurifiedmouseimmunoglobulinIgG1in20mMsodiumphosphate,250mMNaCl,pH.7.6,with0.1%sodiumazideasapreservative. |
| StorageandShippingInformation | |
|---|---|
| StorageConditions | Maintainat2-8°Cinundilutedforupto6monthsafterdateofreceipt. |
| Applications | |
|---|---|
| Application | Anti-GrowthAssociatedProtein43Antibody,clone9-1E12detectslevelofGrowthAssociatedProtein43&hasbeenpublished&validatedforuseinIH,IP&WB. |
| KeyApplications |
|
| ApplicationNotes | Immunohistochemistry: 0.1-0.5µg/mLofapreviousloton4%paraformaldehydeperfusedandfixedratcerebellumandcerebrumtissue.Theadditionof0.01-0.1%TritonX-100toincubationbufferwillincreasecellularpermeABIlity. Immunoprecipitation: Apreviouslotofthisantibodywasusedinimmunoprecipitation. 5-10µg/mLinmembranepreparationsfrom16-18dayembryoniccorticalneuronalcultures. WesternBlotAnalysis: MAB347willdetectasingle43-48kDbandinwesternblotsofmembranefractionsofgrowingneurons. Optimalworkingdilutionsmustbedeterminedbytheenduser. |
| BIOLOGicalInformation | |
|---|---|
| Immunogen | GAP-43purifiedfromratbrain |
| Clone | 9-1E12 |
| Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. |
| Host | Mouse |
| Specificity | GAP-43(alsoknownasgrowthassociatedprotein-43,B-50,F1andpp46),regardlessoftheprotein’sphosphorylationstate. |
| Isotype | IgG1 |
| SpeciesReactivity |
|
| SpeciesReactivityNote | Rat,felineandhamster. Expectedtoreactwithhumanbasedonsequencehomology. |
| AntibodyType | MonoclonalAntibody |
| EntrezGeneNumber | |
| EntrezGeneSummary | Theproteinencodedbythisgenehasbeentermeda"growth"or"plasticity"proteinbecauseitisexpressedathighlevelsinneuronalgrowthconesduringdevelopmentandaxonalregeneration.Thisencodedproteinisconsideredacrucialcomponentofaneffectiveregenerativeresponseinthenervoussystem. |
| GeneSymbol |
|
| PurificationMethod | ProteinAPurfied |
| UniProtNumber | |
| UniProtSummary | FUNCTION:SwissProt:P17677#Thisproteinisassociatedwithnervegrowth.Itisamajorcomponentofthemotilegrowthconesthatformthetipsofelongatingaxons. SIZE:238aminoacids;24803Da SUBUNIT:BindscalmodulinwithagreateraffinityintheabsenceofCa(2+)thaninitspresence(Bysimilarity). SUBCELLULARLOCATION:Cellmembrane;Peripheralmembraneprotein;Cytoplasmicside.Cellprojection,growthconemembrane;Peripheralmembraneprotein;Cytoplasmicside.Celljunction,synapse.Note=Cytoplasmicsurfaceofgrowthconeandsynapticplasmamembranes. PTM:PhosphorylationofthisproteinbyaproteinkinaseCisspecificallycorrelatedwithcertainformsofsynapticplasticity. SIMILARITY:SwissProt:P17677##Belongstotheneuromodulinfamily.&Contains1IQdomain. |
| MolecularWeight | 43-48kDa |
| PhysicochemicalInformation |
|---|
| Dimensions |
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| MaterialsInformation |
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| MaterialsInformation |
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品牌介绍
密理博(Millipore)公司成立于1954年，总部位于美国麻省，在全世界设有47个办事处，为100多个国家提供产品和技术服务。目前全球雇员超过5800人，在美国、法国和日本等国家拥有7家大型生产工厂，主要生产过滤膜及膜过滤产品。20世纪80年代，密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构，并于2000年4月在上海浦东外高桥保税区建立了密理博（上海）贸易有限公司。为了更好地满足中国用户的需求，密理博中国主页于2006年11月向广大用户开放，介绍密理博中国有限公司的最新动态，力求为用户打造专业的产品与服务信息交流平台。
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