Millipore/ABN101 | Anti-GAD65 Antibody/ABN101/100 µg
市场价：
¥6980.00
美元价：
4188.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Description | |
|---|---|
| CatalogueNumber | ABN101 |
| Description | Anti-GAD65Antibody |
| AlternateNames |
|
| BackgroundInformation | GAD65isagroupIIdecarboxylaseenzymethatcatalyzesthebiosynthesisofGABAfromglutamatewiththeaidofthecofactor,pyridoxal5"-phosphate.GAD65localizesatpresynapticGABAergicterminalsandisreportedtosupplylocalvesicularpoolsofGABAfacilitatingtransientinhibitioryneurotransmission,althoughGAD65mayalsoplayaroleinmoresustainedtonicinhibitorysignals.Itispresentasadimerofalphaandbetasubunitsandisregulatedbyalternativesplicing,whichmayproducetheGAD67isoform.GAD65alsoundergoespost-translationalmodificationssuchaspalmitoylationofN-terminalcysteineresiduesandphosphorylationofmultiplealpha-subunitserineresiduesthatenablemembrane-anchoringandothervesicularactivities.GAD65hasbeenimplicatedinneurologicalconditionsresultingfromfailureofinhibitoryneurotransmissionsuchasHuntington"sdiseaseandepilepsy.InadditiontoitsCNSpresence,GAD65alsoproducesGABAinpancreaticbetacellsanddysfunctioninthisareamaycontributetothepathogenesisofinsulin-dependentdiabetesmellitus. |
| ProductInformation | |
|---|---|
| Format | AffinityPurified |
| Control |
|
| Presentation | PurifiedRabbitPolyclonalinbuffercontaining0.1MTris-Glycine(pH7.4),150mMNaClwith0.05%sodiumazide. |
| StorageandShippingInformation | |
|---|---|
| StorageConditions | Stablefor1yearat2-8°Cfromdateofreceipt. |
| BIOLOGicalInformation | |
|---|---|
| Immunogen | KLH-conjugatedlinearpeptidecorrespondingtohumanGAD65. |
| Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. |
| Host | Rabbit |
| SpeciesReactivity |
|
| SpeciesReactivityNote | DemonstratedtoreactwithRat,Mouse,andHuman.PredictedtoreactwithCanineandPorcinebasedon100%sequencehomology. |
| AntibodyType | PolyclonalAntibody |
| EntrezGeneNumber | |
| GeneSymbol |
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| PurificationMethod | AffinityPurfied |
| UniProtNumber | |
| MolecularWeight | ~59/63kDaobserved.Thecalculatedmolecularweightis65kDa,howeverGAD65hasbeenshownasa~59/63doubletinwesternblots.(Christgau,S.,etal.(1991).JournalofBiologicalChemistry.266(31):21257-21264.)Anuncharacterizedbandappearsat~38kDainsomelysates. |
| PhysicochemicalInformation |
|---|
| Dimensions |
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| MaterialsInformation |
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| MaterialsInformation |
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品牌介绍
密理博(Millipore)公司成立于1954年，总部位于美国麻省，在全世界设有47个办事处，为100多个国家提供产品和技术服务。目前全球雇员超过5800人，在美国、法国和日本等国家拥有7家大型生产工厂，主要生产过滤膜及膜过滤产品。20世纪80年代，密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构，并于2000年4月在上海浦东外高桥保税区建立了密理博（上海）贸易有限公司。为了更好地满足中国用户的需求，密理博中国主页于2006年11月向广大用户开放，介绍密理博中国有限公司的最新动态，力求为用户打造专业的产品与服务信息交流平台。
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