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Millipore/06-172 | Anti-Na+/K+ ATPase α-3 Antibody/06-172/125 µg

Millipore/06-172 | Anti-Na+/K+ ATPase α-3 Antibody/06-172/125 µg
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产品分类:
功能性抗体
公司分类:
Functional_antibody
联系Q Q:
3392242852
电话号码:
4000-520-616
电子邮箱:
info@ebiomall.com
商品介绍
Description | |
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CatalogueNumber | 06-172 |
BrandFamily | Upstate |
TradeName |
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Description | Anti-Na+/K+ATPaseα-3Antibody |
ProductInformation | |
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Format | Purified |
Presentation | 0.1MTris-HCl,pH7.2,containing0.02%sodiumazide |
StorageandShippingInformation | |
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StorageConditions | 2yearsat-20°C |
Applications | |
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Application | Anti-Na+/K+ATPaseα-3AntibodydetectslevelofNa+/K+ATPaseα-3&hasbeenpublished&validatedforuseinIH&WB. |
KeyApplications |
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BIOLOGicalInformation | |
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Immunogen | Fusionproteinderivedthealpha3subunitcontainingresidues320-514 |
Host | Rabbit |
Specificity | Na+/K+ATPaseα-3 |
Isotype | IgG |
SpeciesReactivity |
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AntibodyType | PolyclonalAntibody |
EntrezGeneNumber | |
EntrezGeneSummary | TheproteinencodedbythisgenebelongstothefamilyofP-typecationtransportATPases,andtothesubfamilyofNa+/K+-ATPases.Na+/K+-ATPaseisanintegralmembraneproteinresponsIBLeforestablishingandmaintainingtheelectRochemicalgrADIentsofNaandKionsacrosstheplasmamembrane.Thesegradientsareessentialforosmoregulation,forsodium-coupledtransportofavarietyoforganicandinorganicmolecules,andforelectricalexcitABIlityofnerveandmuscle.Thisenzymeiscomposedoftwosubunits,alargecatalyticsubunit(alpha)andasmallerglycoproteinsubunit(beta).ThecatalyticsubunitofNa+/K+-ATPaseisencodedbymultiplegenes.Thisgeneencodesanalpha3subunit. |
GeneSymbol |
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PurificationMethod | ProteinAchromatography |
UniProtNumber | |
UniProtSummary | FUNCTION:SwissProt:P13637#Thisisthecatalyticcomponentoftheactiveenzyme,whichcatalyzesthehydrolysisofATPcoupledwiththeexchangeofsodiumandpotassiumionsacrosstheplasmamembrane.Thisactioncreatestheelectrochemicalgradientofsodiumandpotassiumions,providingtheenergyforactivetransportofvariousnutrients. SIZE:1013aminoacids;111749Da SUBUNIT:Composedofthreesubunits:alpha(catalytic),betaandgamma. SUBCELLULARLOCATION:Membrane;Multi-passmembraneprotein. DISEASE:SwissProt:P13637#DefectsinATP1A3arethecauseofdystonia-12(DYT12)[MIM:128235];alsoknownasrapid-onsetdystoniaparkinsonism(RDP).DYT12isanautosomaldominantformofdystonia-parkinsonismcharacterizedbyanunusuallyrapidevolutionofsignsandsymptoms.Affectedpersonsdevelopdystoniaandparkinsonismbetween14and45yearsofage.Thesuddenonsetofsymptomsoverhourstoafewweeks,oftenassociatedwithphysicaloremotionalstress,suggestsatriggerinitiatinganervoussysteminsultresultinginpermanentneurologicdisability. SIMILARITY:SwissProt:P13637##BelongstothecationtransportATPase(P-type)family.TypeIICsubfamily. |
MolecularWeight | 112kDa |
PhysicochemicalInformation |
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Dimensions |
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MaterialsInformation |
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MaterialsInformation |
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品牌介绍
密理博(Millipore)公司成立于1954年,总部位于美国麻省,在全世界设有47个办事处,为100多个国家提供产品和技术服务。目前全球雇员超过5800人,在美国、法国和日本等国家拥有7家大型生产工厂,主要生产过滤膜及膜过滤产品。20世纪80年代,密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构,并于2000年4月在上海浦东外高桥保税区建立了密理博(上海)贸易有限公司。为了更好地满足中国用户的需求,密理博中国主页于2006年11月向广大用户开放,介绍密理博中国有限公司的最新动态,力求为用户打造专业的产品与服务信息交流平台。
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