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当前位置: 首页 > 产品中心 > Functional_antibody > Millipore/06-172 | Anti-Na+/K+ ATPase α-3 Antibody/06-172/125 µg
商品详细Millipore/06-172 | Anti-Na+/K+ ATPase α-3 Antibody/06-172/125 µg
Millipore/06-172 | Anti-Na+/K+ ATPase α-3 Antibody/06-172/125 µg
Millipore/06-172 | Anti-Na+/K+ ATPase α-3 Antibody/06-172/125 µg
商品编号: 06-172
品牌: 密理博
市场价: ¥0.00
美元价: 0.00
产地: 美国(厂家直采)
公司:
产品分类: 功能性抗体
公司分类: Functional_antibody
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍
Description
CatalogueNumber06-172
BrandFamilyUpstate
TradeName
  • Upstate
DescriptionAnti-Na+/K+ATPaseα-3Antibody
ProductInformation
FormatPurified
Presentation0.1MTris-HCl,pH7.2,containing0.02%sodiumazide
StorageandShippingInformation
StorageConditions2yearsat-20°C
Applications
ApplicationAnti-Na+/K+ATPaseα-3AntibodydetectslevelofNa+/K+ATPaseα-3&hasbeenpublished&validatedforuseinIH&WB.
KeyApplications
  • Immunohistochemistry
  • WesternBlotting
BIOLOGicalInformation
ImmunogenFusionproteinderivedthealpha3subunitcontainingresidues320-514
HostRabbit
SpecificityNa+/K+ATPaseα-3
IsotypeIgG
SpeciesReactivity
  • Rat
AntibodyTypePolyclonalAntibody
EntrezGeneNumber
EntrezGeneSummaryTheproteinencodedbythisgenebelongstothefamilyofP-typecationtransportATPases,andtothesubfamilyofNa+/K+-ATPases.Na+/K+-ATPaseisanintegralmembraneproteinresponsIBLeforestablishingandmaintainingtheelectRochemicalgrADIentsofNaandKionsacrosstheplasmamembrane.Thesegradientsareessentialforosmoregulation,forsodium-coupledtransportofavarietyoforganicandinorganicmolecules,andforelectricalexcitABIlityofnerveandmuscle.Thisenzymeiscomposedoftwosubunits,alargecatalyticsubunit(alpha)andasmallerglycoproteinsubunit(beta).ThecatalyticsubunitofNa+/K+-ATPaseisencodedbymultiplegenes.Thisgeneencodesanalpha3subunit.
GeneSymbol
  • ATP1A3
  • MGC13276
  • RDP
  • IIIsubunit).
  • DYT12
  • +K
  • Na
PurificationMethodProteinAchromatography
UniProtNumber
UniProtSummaryFUNCTION:SwissProt:P13637#Thisisthecatalyticcomponentoftheactiveenzyme,whichcatalyzesthehydrolysisofATPcoupledwiththeexchangeofsodiumandpotassiumionsacrosstheplasmamembrane.Thisactioncreatestheelectrochemicalgradientofsodiumandpotassiumions,providingtheenergyforactivetransportofvariousnutrients.
SIZE:1013aminoacids;111749Da
SUBUNIT:Composedofthreesubunits:alpha(catalytic),betaandgamma.
SUBCELLULARLOCATION:Membrane;Multi-passmembraneprotein.
DISEASE:SwissProt:P13637#DefectsinATP1A3arethecauseofdystonia-12(DYT12)[MIM:128235];alsoknownasrapid-onsetdystoniaparkinsonism(RDP).DYT12isanautosomaldominantformofdystonia-parkinsonismcharacterizedbyanunusuallyrapidevolutionofsignsandsymptoms.Affectedpersonsdevelopdystoniaandparkinsonismbetween14and45yearsofage.Thesuddenonsetofsymptomsoverhourstoafewweeks,oftenassociatedwithphysicaloremotionalstress,suggestsatriggerinitiatinganervoussysteminsultresultinginpermanentneurologicdisability.
SIMILARITY:SwissProt:P13637##BelongstothecationtransportATPase(P-type)family.TypeIICsubfamily.
MolecularWeight112kDa
PhysicochemicalInformation
Dimensions
MaterialsInformation
MaterialsInformation
品牌介绍
密理博(Millipore)公司成立于1954年,总部位于美国麻省,在全世界设有47个办事处,为100多个国家提供产品和技术服务。目前全球雇员超过5800人,在美国、法国和日本等国家拥有7家大型生产工厂,主要生产过滤膜及膜过滤产品。20世纪80年代,密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构,并于2000年4月在上海浦东外高桥保税区建立了密理博(上海)贸易有限公司。为了更好地满足中国用户的需求,密理博中国主页于2006年11月向广大用户开放,介绍密理博中国有限公司的最新动态,力求为用户打造专业的产品与服务信息交流平台。