milipore/MABS50 |抗Cdk5抗体，克隆1H3/MABS50/100µ；G
市场价：
¥5540.00
美元价：
3324.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Description | |
|---|---|
| CatalogueNumber | MABS50 |
| Description | Anti-Cdk5Antibody,clone1H3 |
| AlternateNames |
|
| BackgroundInformation | Cyclin-dependentkinase5(CDK5),belongstothecyclin-dependentkinasefamily.Itismostactiveinthecentralnervoussystemandplaysanimportantroleintheregulationofcytoskeletalfunction.CDK5expressionhasbeenobservedintestis,kidney,andovarywithhigherlevelsseeninpostmitoticneuronsindevelopingandadultnervoussystems.MutationsinCDK5havebeenassociatedwithAlzheimer"sdisease,Parkinson"sdisease,andALS,suggestingthatCDK5mayplayakeyroleinseveralneurodegenerativedisorders. |
| ProductInformation | |
|---|---|
| Format | Purified |
| Control |
|
| Presentation | PurifiedmousemonoclonalIgG1κinbuffercontaining0.1MTris-Glycine(pH7.4),150mMNaClwith0.05%sodiumazide. |
| StorageandShippingInformation | |
|---|---|
| StorageConditions | Stablefor1yearat2-8°Cfromdateofreceipt. |
| BIOLOGicalInformation | |
|---|---|
| Immunogen | HumanCDK5crosslinkedtohomogenizedsurgicalsuturematerial |
| Clone | 1H3 |
| Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. |
| Host | Mouse |
| Specificity | ThisantibodyrecognizesCDK5. |
| Isotype | IgG1κ |
| SpeciesReactivity |
|
| SpeciesReactivityNote | Demonstratedtoreactwithhuman.Predictedtoreactwithmouseandratbasedon100%sequencehomology. |
| AntibodyType | MonoclonalAntibody |
| EntrezGeneNumber | |
| GeneSymbol |
|
| PurificationMethod | ProteinGPurified |
| UniProtNumber | |
| UniProtSummary | FUNCTION:Probablyinvolvedinthecontrolofthecellcycle.InteractswithD1andD3-typeG1cyclins.CanphosphorylatehistoneH1,tau,MAP2andNF-HandNF-M.Alsointeractswithp35whichactivatesthekinase. SIZE:292aminoacids;33304Da SUBUNIT:Heterodimerofacatalyticsubunitandaregulatorysubunit(p35).FoundinatrimolecularcomplexwithCABLES1andABL1.InteractswithCABLES1(Bysimilarity).InteractswithAATK. SUBCELLULARLOCATION:Cytoplasm(Bysimilarity).Cellprojection,lamellipodium(Bysimilarity).Cellprojection,growthcone(Bysimilarity).Note=Inaxonalgrowthconewithextensiontotheperipherallamellipodia(Bysimilarity). SIMILARITY:Belongstotheproteinkinasesuperfamily.CMGCSer/Thrproteinkinasefamily.CDC2/CDKXsubfamily.&Contains1proteinkinasedomain....hide»seemore» |
| MolecularWeight | 33kDaobserved |
| PhysicochemicalInformation |
|---|
| Dimensions |
|---|
| MaterialsInformation |
|---|
| MaterialsInformation |
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品牌介绍
密理博(Millipore)公司成立于1954年，总部位于美国麻省，在全世界设有47个办事处，为100多个国家提供产品和技术服务。目前全球雇员超过5800人，在美国、法国和日本等国家拥有7家大型生产工厂，主要生产过滤膜及膜过滤产品。20世纪80年代，密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构，并于2000年4月在上海浦东外高桥保税区建立了密理博（上海）贸易有限公司。为了更好地满足中国用户的需求，密理博中国主页于2006年11月向广大用户开放，介绍密理博中国有限公司的最新动态，力求为用户打造专业的产品与服务信息交流平台。
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