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当前位置: 首页 > 产品中心 > Functional_antibody > milipore/MABS50 |抗Cdk5抗体,克隆1H3/MABS50/100µ;G
商品详细milipore/MABS50 |抗Cdk5抗体,克隆1H3/MABS50/100µ;G
milipore/MABS50 |抗Cdk5抗体,克隆1H3/MABS50/100µ;G
milipore/MABS50 |抗Cdk5抗体,克隆1H3/MABS50/100µ;G
商品编号: MABS50
品牌: 密理博
市场价: ¥5540.00
美元价: 3324.00
产地: 美国(厂家直采)
公司:
产品分类: 功能性抗体
公司分类: Functional_antibody
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍
Description
CatalogueNumberMABS50
DescriptionAnti-Cdk5Antibody,clone1H3
AlternateNames
  • cyclin-dependentkinase5
  • TauproteinkinaseIIcatalyticsubunit
  • Serine/threonine-proteinkinasePSSALRE
  • proteinkinaseCDK5splicing
  • TPKIIcatalyticsubunit
BackgroundInformationCyclin-dependentkinase5(CDK5),belongstothecyclin-dependentkinasefamily.Itismostactiveinthecentralnervoussystemandplaysanimportantroleintheregulationofcytoskeletalfunction.CDK5expressionhasbeenobservedintestis,kidney,andovarywithhigherlevelsseeninpostmitoticneuronsindevelopingandadultnervoussystems.MutationsinCDK5havebeenassociatedwithAlzheimer"sdisease,Parkinson"sdisease,andALS,suggestingthatCDK5mayplayakeyroleinseveralneurodegenerativedisorders.
ProductInformation
FormatPurified
Control
  • HeLacelllysate
PresentationPurifiedmousemonoclonalIgG1κinbuffercontaining0.1MTris-Glycine(pH7.4),150mMNaClwith0.05%sodiumazide.
StorageandShippingInformation
StorageConditionsStablefor1yearat2-8°Cfromdateofreceipt.
Applications
ApplicationAnti-Cdk5Antibody,clone1H3detectslevelofCdk5&hasbeenpublished&validatedforuseinWB,IC,IH.
KeyApplications
  • WesternBlotting
  • Immunocytochemistry
  • Immunohistochemistry
ApplicationNotesImmunocytochemistryAnalysis:ThisantibodyhasbeenshowntodetectCDK5inmousebrainhistologicalsections.(Legace,D.C.,etal.(2008).ProcNatlAcadSciUSA.105:18567-18571.)
BIOLOGicalInformation
ImmunogenHumanCDK5crosslinkedtohomogenizedsurgicalsuturematerial
Clone1H3
ConcentrationPleaserefertotheCertificateofAnalysisforthelot-specificconcentration.
HostMouse
SpecificityThisantibodyrecognizesCDK5.
IsotypeIgG1κ
SpeciesReactivity
  • Human
  • Mouse
  • Rat
SpeciesReactivityNoteDemonstratedtoreactwithhuman.Predictedtoreactwithmouseandratbasedon100%sequencehomology.
AntibodyTypeMonoclonalAntibody
EntrezGeneNumber
GeneSymbol
  • CDK5
  • PSSALRE
PurificationMethodProteinGPurified
UniProtNumber
UniProtSummaryFUNCTION:Probablyinvolvedinthecontrolofthecellcycle.InteractswithD1andD3-typeG1cyclins.CanphosphorylatehistoneH1,tau,MAP2andNF-HandNF-M.Alsointeractswithp35whichactivatesthekinase.

SIZE:292aminoacids;33304Da

SUBUNIT:Heterodimerofacatalyticsubunitandaregulatorysubunit(p35).FoundinatrimolecularcomplexwithCABLES1andABL1.InteractswithCABLES1(Bysimilarity).InteractswithAATK.

SUBCELLULARLOCATION:Cytoplasm(Bysimilarity).Cellprojection,lamellipodium(Bysimilarity).Cellprojection,growthcone(Bysimilarity).Note=Inaxonalgrowthconewithextensiontotheperipherallamellipodia(Bysimilarity).

SIMILARITY:Belongstotheproteinkinasesuperfamily.CMGCSer/Thrproteinkinasefamily.CDC2/CDKXsubfamily.&Contains1proteinkinasedomain....hide»seemore»
MolecularWeight33kDaobserved
PhysicochemicalInformation
Dimensions
MaterialsInformation
MaterialsInformation
品牌介绍
密理博(Millipore)公司成立于1954年,总部位于美国麻省,在全世界设有47个办事处,为100多个国家提供产品和技术服务。目前全球雇员超过5800人,在美国、法国和日本等国家拥有7家大型生产工厂,主要生产过滤膜及膜过滤产品。20世纪80年代,密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构,并于2000年4月在上海浦东外高桥保税区建立了密理博(上海)贸易有限公司。为了更好地满足中国用户的需求,密理博中国主页于2006年11月向广大用户开放,介绍密理博中国有限公司的最新动态,力求为用户打造专业的产品与服务信息交流平台。