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微孔/CBL412A5 |抗微管蛋白β-Ⅲ抗体，克隆TU-20，Alexa Fluor®555共轭物/CBL412A5/100µ；L
微孔/CBL412A5 |抗微管蛋白β-Ⅲ抗体，克隆TU-20，Alexa Fluor®555共轭物/CBL412A5/100µ；L
市场价：
¥7800.00
美元价：
4680.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Description | |
|---|---|
| CatalogueNumber | CBL412A5 |
| Description | Anti-Tubulinβ-IIIAntibody,cloneTU-20,AlexaFluor®555Conjugate |
| AlternateNames |
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| BackgroundInformation | Tubulinisoneofseveralmembersofasmallfamilyofglobularproteinswhichpolymerizetoformcytoskeletalstructurescalledmicrotubules.Themostcommonmembersofthetubulinfamilyareα-tubulinandβ-tubulin.Tubulindimers,typicallycomposedofα-andβ-tubulinsubunits,assembleontomicrotubulesforminglargepolymers.β-IIItubulinisauniquemicrotubulesubunitthatisfoundexpressedalmostexclusivelyinneurons.Duetotheuniqueexpressionpatternofβ-IIItubulinitisoftenutilizedasaMarkertoidentifyneuronalcellsfromotherbraincellssuchasgliawhichdonotexpressit.β-IIItubulinalsoservesasacytoarchitecturalmarkersinceitisprimarilyfoundwithinneuriteextensions. |
| ProductInformation | |
|---|---|
| Format | AlexaFluor®555 |
| Control |
|
| Presentation | PurifiedmousemonoclonalIgG1conjugatedtoAlexaFluor®555inPBSwith0.1%sodiumazideand15mg/mLBSA. |
| StorageandShippingInformation | |
|---|---|
| StorageConditions | Maintainrefrigeratedat2-8°Cprotectedfromlightinundilutedaliquotsforupto6monthsfromdateofreceipt. |
| Applications | |
|---|---|
| Application | DetectTubulinβ-IIIusingthisAnti-Tubulinβ-IIIAntibody,cloneTU-20,AlexaFluor®555ConjugatevalidatedforuseinICC. |
| KeyApplications |
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| BIOLOGicalInformation | |
|---|---|
| Immunogen | SyntheticpeptidecorrespondingtohumanTubulinβ-III. |
| Epitope | C-terminus |
| Clone | TU-20 |
| Host | Mouse |
| Specificity | ThisantibodyreactswiththeC-terminusofthebeta-IIIisoformoftubulin,whichisknowntobeneuronspecific.Doesnotidentifybetatubulinfoundinglialcells. |
| Isotype | IgG1 |
| SpeciesReactivity |
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| SpeciesReactivityNote | DemonstratedtoreactwithRat.PredictedtoreactwithMouse,Porcine,Primate,andBovinebasedon100%sequencehomology. |
| AntibodyType | MonoclonalAntibody |
| EntrezGeneNumber | |
| EntrezGeneSummary | ThisgeneencodesaclassIIImemberofthebetatubulinproteinfamily.Betatubulinsareoneoftwocoreproteinfamilies(alphaandbetatubulins)thatheterodimerizeandassembletoformmicrotubules.Thisproteinisprimarilyexpressedinneuronsandmaybeinvolvedinneurogenesisandaxonguidanceandmaintenance.Mutationsinthisgenearethecauseofcongenitalfibrosisoftheextraocularmusclestype3.Alternatesplicingresultsinmultipletranscriptvariants.Apseudogeneofthisgeneisfoundonchromosome6.[providedbyRefSeq,Oct2010]. |
| GeneSymbol |
|
| PurificationMethod | ProteinGPurified |
| UniProtNumber | |
| UniProtSummary | FUNCTION:Tubulinisthemajorconstituentofmicrotubules.ItbindstwomolesofGTP,oneatanexchangeablesiteonthebetachainandoneatanon-exchangeablesiteonthealpha-chain.TUBB3playsacriticalroleinproperaxonguidanceandmantainance. SUBUNITSTRUCTURE:Dimerofalphaandbetachains. SUBCELLULARLOCATION:Cytoplasm›Cytoskeleton. TISSUESPECIFICITY:Expressionisprimarilyrestrictedtocentralandperipheralnervoussystem.Greatlyincreasedexpressioninmostcanceroustissues. DOMAIN:ThehighlyacidicC-terminalregionmaybindcationssuchascalcium. PTM:SomeglutamateresiduesattheC-terminusarepolyglutamylated.Thismodificationoccursexclusivelyonglutamateresiduesandresultsinpolyglutamatechainsonthegamma-carboxylgroup.AlsomonoglycylatedbutnotpolyglycylatedduetotheabsenceoffunctionalTTLL10inhuman.Monoglycylationismainlylimitedtotubulinincorporatedintoaxonemes(ciliaandflagella)whereasglutamylationisprevalentinneuronalcells,centrioles,axonemes,andthemitoticspindle.Bothmodificationscancoexistonthesameproteinonadjacentresidues,andloweringglycylationlevelsincreasespolyglutamylation,andreciprocally.TheprecisefunctionofsuchmodificationsisstillunclearbuttheyregulatetheassemblyanddynamicsofaxonemalmicrotubulesProbable. PhosphorylatedonSer-172byCDK1duringthecellcycle,frommetaphasetotelophase,butnotininterphase.Thisphosphorylationinhibitstubulinincorporationintomicrotubules. INVOLVEMENTINDISEASE:DefectsinTUBB3arethecauseofcongenitalfibrosisofextraocularmusclestype3A(CFEOM3A)[MIM:600638].Acongenitalocularmotilitydisordermarkedbyrestrictiveophthalmoplegiaaffectingextraocularmusclesinnervatedbytheoculomotorand/ortrochlearnerves.Itisclinicallycharacterizedbyanchoringoftheeyesindownwardgaze,ptosis,andbackwardtiltofthehead.Congenitalfibrosisofextraocularmusclestype3presentsasanon-progressive,autosomaldominantdisorderwithvariableexpression.Patientsmaybebilaterallyorunilaterallyaffected,andtheiroculo-motilitydefectsrangefromcompleteophthalmoplegia(withtheeyesfixedinahypo-andexotropicposition),tomildasymptomaticrestrictionsofocularmovement.Ptosis,refractiveerror,amblyopia,andcompensatoryheadpositionsareassociatedwiththemoresevereformsofthedisorder.Insomecasestheocularphenotypeisaccompaniedbyadditionalfeaturesincludingdevelopmentaldelay,corpuscallosumagenesis,basalgangliadysmorphism,facialweakness,polyneuropathy. SEQUENCESIMILARITIES:Belongstothetubulinfamily. |
| MolecularWeight | Theunconjugatedparentantibody(Cat.No.MAB1637)hasanobservedmolecularweightat~55kDa. |
| PhysicochemicalInformation |
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| Dimensions |
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| MaterialsInformation |
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| MaterialsInformation |
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品牌介绍
密理博(Millipore)公司成立于1954年，总部位于美国麻省，在全世界设有47个办事处，为100多个国家提供产品和技术服务。目前全球雇员超过5800人，在美国、法国和日本等国家拥有7家大型生产工厂，主要生产过滤膜及膜过滤产品。20世纪80年代，密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构，并于2000年4月在上海浦东外高桥保税区建立了密理博（上海）贸易有限公司。为了更好地满足中国用户的需求，密理博中国主页于2006年11月向广大用户开放，介绍密理博中国有限公司的最新动态，力求为用户打造专业的产品与服务信息交流平台。
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