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4000-520-616
当前位置: 首页 > 产品中心 > Functional_antibody > Millipore/AB5898 | Anti-Protein Gene Product 9.5 Antibody/AB5898/50 µL
商品详细Millipore/AB5898 | Anti-Protein Gene Product 9.5 Antibody/AB5898/50 µL
Millipore/AB5898 | Anti-Protein Gene Product 9.5 Antibody/AB5898/50 µL
Millipore/AB5898 | Anti-Protein Gene Product 9.5 Antibody/AB5898/50 µL
商品编号: AB5898
品牌: 密理博
市场价: ¥7180.00
美元价: 4308.00
产地: 美国(厂家直采)
公司:
产品分类: 功能性抗体
公司分类: Functional_antibody
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍
Description
CatalogueNumberAB5898
BrandFamilyChemicon®
TradeName
  • Chemicon
DescriptionAnti-ProteinGeneProduct9.5Antibody
AlternateNames
  • PGP9.5
  • UCH-L1
ProductInformation
FormatSerum
Control
  • Braintissue
PresentationLiquid.Contains0.05%sodiumazide.
StorageandShippingInformation
StorageConditionsMaintainfor1yearat-20°Cfromdateofshipment.Aliquottoavoidrepeatedfreezingandthawing.Formaximumrecoveryofproduct,centrifugetheoriginalvialafterthawingandpriortoremovingthecap.
Applications
ApplicationAnti-ProteinGeneProduct9.5AntibodydetectslevelofProteinGeneProduct9.5&hasbeenpublished&validatedforuseinIH.
KeyApplications
  • Immunohistochemistry
ApplicationNotesImmunohistochemistry:1:500.

Optimalworkingdilutionsmustbedeterminedbyenduser.

blockingbufferfor1houratroomtemperature.Primaryantibodywasdilutedinblockingbuffertotheappropriateworkingdilution.Blockingbufferwasremovedandtheslideswerethenincubatedat4°Cfor18-24hourswithAB5898(1:500).AfterrinsinginPBS3timessectionswereincubatedfor60minutesatroomtemperaturewithCy3-conjugatedsecondaryantibodies.AftermountinginamixtureofPBSandglycerol(1:3)containing0.1%p-phenylenediamine,sectionswereexaminedwithaNikonMicrophot-SAepifluorescencemicroscope.
BIOLOGicalInformation
ImmunogenA17aminoacidpeptidecorrespondingtoaminoacids175-191fromsolublecytoplasmichumanPGP9.5.
ConcentrationPleaserefertotheCertificateofAnalysisforthelot-specificconcentration.
HostGuineaPig
SpecificityRecognizesProteinGeneProduct9.5(PGP9.5).
SpeciesReactivity
  • Human
  • Mouse
  • Rat
AntibodyTypePolyclonalAntibody
EntrezGeneNumber
EntrezGeneSummaryUCHL1isamemberofagenefamilywhoseproductshydrolyzesmallC-terminaladductsofubiquitintogeneratetheubiquitinmonomer.ExpressionofUCHL1ishighlyspecifictoneuronsandtocellsofthediffuseneuroendocrinesystemandtheirtumors.Itispresentinallneurons(Doranetal.,1983[PubMed6343558]).[suppliedbyOMIM]
GeneSymbol
  • UCHL1
  • PARK5
  • UCH-L1
  • Uch-L1
  • PGP9.5
  • EC3.4.19.12
  • EC6.-.-.-
PurificationMethodUnpurified
UniProtNumber
UniProtSummaryFUNCTION:SwissProt:P09936#Ubiquitin-proteinhydrolaseinvolvedbothintheprocessingofubiquitinprecursorsandofubiquitinatedproteins.ThisenzymeisathiolproteasethatrecognizesandhydrolyzesapeptidebondattheC-terminalglycineofubiquitin.Alsobindstofreemonoubiquitinandmaypreventitsdegradationinlysosomes.ThehomodimermayhaveATP-independentubiquitinligaseactivity.
SIZE:223aminoacids;24824Da
SUBUNIT:Homodimer.InteractswithSNCA(Bysimilarity).InteractswithCOPS5.
SUBCELLULARLOCATION:Cytoplasm.
TISSUESPECIFICITY:Foundinneuronalcellbodiesandprocessesthroughouttheneocortex(atproteinlevel).Expressedinneuronsandcellsofthediffuseneuroendocrinesystemandtheirtumors.Weaklyexpressedinovary.
PTM:O-glycosylated(Bysimilarity).
DISEASE:SwissProt:P09936#OxidationofMet-1,Met-6,Met-12,Met-124andMet-179tomethioninesulfoxide,andoxidationofCys-220tocysteinesulfonicacidhavebeenobservedinbrainsfromAlzheimerdisease(AD)andParkinsondisease(PD)patients.InAD,UCHL1wasfoundtobeassociatedwithneurofibrillarytangles.
SIMILARITY:SwissProt:P09936##BelongstothepeptidaseC12family.
MISCELLANEOUS:IncontrasttoUCHL3,doesnothydrolyzeapeptidebondattheC-terminalglycineofNEDD8.
PhysicochemicalInformation
Dimensions
MaterialsInformation
MaterialsInformation
品牌介绍
密理博(Millipore)公司成立于1954年,总部位于美国麻省,在全世界设有47个办事处,为100多个国家提供产品和技术服务。目前全球雇员超过5800人,在美国、法国和日本等国家拥有7家大型生产工厂,主要生产过滤膜及膜过滤产品。20世纪80年代,密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构,并于2000年4月在上海浦东外高桥保税区建立了密理博(上海)贸易有限公司。为了更好地满足中国用户的需求,密理博中国主页于2006年11月向广大用户开放,介绍密理博中国有限公司的最新动态,力求为用户打造专业的产品与服务信息交流平台。