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Millipore/07-1238 | Anti-phospho-MARCKS (Ser152/156) Antibody/07-1238/100 µL
Millipore/07-1238 | Anti-phospho-MARCKS (Ser152/156) Antibody/07-1238/100 µL
市场价：
¥5540.00
美元价：
3324.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Description | |
|---|---|
| CatalogueNumber | 07-1238 |
| Replaces | AB5879 |
| Description | Anti-phospho-MARCKS(Ser152/156)Antibody |
| AlternateNames |
|
| BackgroundInformation | MyristoylatedAlanine-RichC-KinaseSubstrate(MARCKS)isawidelyexpressedsubstrateofPKC.MARCKSisessentialinneuronaldevelopment,asmicedeficientinitdieshortlyafterbirth.Throughitsbasiceffectorregion,MARCKSassociateswithacidicmembranephospholipids,actinfilaments,andcalmodulin.Poly(ADP-ribose)alsobindsthebasiceffectorregion,blockingcalmodulinbinding,membraneassociation,andphosphorylationbyPKC,suggestingthatMARCKSmaybeaneffectoroftheDNA-damagesignaltransducedbypoly(ADP-ribose). |
| ProductInformation | |
|---|---|
| Format | AffinityPurified |
| Control |
|
| Presentation | PurifiedrabbitpolyclonalIgGin10mMHepes,pH7.5,with150mMNaCl,100µg/mLBSAand50%glycerol. |
| StorageandShippingInformation | |
|---|---|
| StorageConditions | Stableat-20°Cinundilutedforupto6monthsfromdateofreceipt.Avoidrepeatedfreeze/thawcycles.Donotstoreinaself-defrostingfreezer. HandlingRecommendations:Uponfirstthaw,andpriortoremovingthecap,centrifugethevialandgentlymixthesolution.Aliquotintomicrocentrifugetubesandstoreat-20°C.Avoidrepeatedfreeze/thawcycles,whichmaydamageIgGandaffectproductperformance.Note:VariABIlityinfreezertemperaturesbelow-20°Cmaycauseglycerolcontainingsolutionstobecomefrozenduringstorage. |
| BIOLOGicalInformation | |
|---|---|
| Immunogen | SyntheticpeptidecorrespondingtoaminoacidssurroundingthephosphoSer152/156ofratMARCKS. |
| Epitope | phosphoSer152/156 |
| Host | Rabbit |
| Specificity | MARCKS,phosphoSer152/156. |
| Isotype | IgG |
| SpeciesReactivity |
|
| AntibodyType | PolyclonalAntibody |
| EntrezGeneNumber | |
| EntrezGeneSummary | TheproteinencodedbythisgeneisasubstrateforproteinkinaseC.Itislocalizedtotheplasmamembraneandisanactinfilamentcrosslinkingprotein.PhosphorylationbyproteinkinaseCorbindingtocalcium-calmodulininhibitsitsassociationwithactinandwiththeplasmamembrane,leADIngtoitspresenceinthecytoplasm.Theproteinisthoughttobeinvolvedincellmotility,phagocytosis,membranetraffickingandmitogenesis. |
| GeneSymbol |
|
| Modifications |
|
| PurificationMethod | AffinityPurfied |
| UniProtNumber | |
| UniProtSummary | FUNCTION:SwissProt:P29966#MARCKSisthemostprominentcellularsubstrateforproteinkinaseC.Thisproteinbindscalmodulin,actin,andsynapsin.MARCKSisafilamentous(F)actincross-linkingprotein. SIZE:332aminoacids;31555Da PTM:PhosphorylationbyPKCdisplacesMARCKSfromthemembrane.ItalsoinhibitstheF-actincross-linkingactivity. SIMILARITY:SwissProt:P29966##BelongstotheMARCKSfamily. |
| MolecularWeight | ~80kDa |
| PhysicochemicalInformation |
|---|
| Dimensions |
|---|
| MaterialsInformation |
|---|
| MaterialsInformation |
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品牌介绍
密理博(Millipore)公司成立于1954年，总部位于美国麻省，在全世界设有47个办事处，为100多个国家提供产品和技术服务。目前全球雇员超过5800人，在美国、法国和日本等国家拥有7家大型生产工厂，主要生产过滤膜及膜过滤产品。20世纪80年代，密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构，并于2000年4月在上海浦东外高桥保税区建立了密理博（上海）贸易有限公司。为了更好地满足中国用户的需求，密理博中国主页于2006年11月向广大用户开放，介绍密理博中国有限公司的最新动态，力求为用户打造专业的产品与服务信息交流平台。
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