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Millipore/MAB1904 | Anti-Laminin-1 A&B chains Antibody, cross region, clone AL-2/MAB1904/100 µg
Millipore/MAB1904 | Anti-Laminin-1 A&B chains Antibody, cross region, clone AL-2/MAB1904/100 µg
市场价：
¥6580.00
美元价：
3948.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Description | |
|---|---|
| CatalogueNumber | MAB1904 |
| BrandFamily | Chemicon® |
| TradeName |
|
| Description | Anti-Laminin-1A&BchainsAntibody,crossregion,cloneAL-2 |
| AlternateNames |
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| BackgroundInformation | Lamininsaresecretedglycoproteinsincorporatedintocell-associatedextracellularmatricesandanintegralpartofthestructuralscaffoldinginmostanimaltissues.Thelamininproteinismadeupofthreepolypeptidechains;α,βandγ,accountingforitsflexibilityinconnectingvariousmolecules.Whenoriginallycharacterized,laminin-1cloneAL-2reactedwithEngelbreth-Holm-Swarm(EHS)mouselamininA&Bchainsonthelongarmnearthecrossregion,(Skubitz,1987).Morerecently,investigations,(Schèele,2006)haveshownthattheclonebindslamininβ1underreducingconditionsaswellasnativeELISAsandthattheaffinityisincreasedbythepresenceofthelamininα1chain.Thusthereissignificantlamininβ1reactivitywithcloneAL-2. |
| ProductInformation | |
|---|---|
| Format | Purified |
| Presentation | Purifiedin0.1MTris-Glycine(pH7.4)150mMNaClwith0.05%NaN3. |
| StorageandShippingInformation | |
|---|---|
| StorageConditions | Maintainat2-8°Cinundilutedaliquotsforupto1yearafterdateofreceipt. |
| BIOLOGicalInformation | |
|---|---|
| Immunogen | LamininisolatedfromEHSmousesarcoma. |
| Epitope | Nearcrossregion |
| Clone | AL-2 |
| Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. |
| Host | Rat |
| Specificity | ReactswithEHSmouselamininA&Bchainsonthelongarmnearthecrossregion. |
| Isotype | IgG1κ |
| SpeciesReactivity |
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| SpeciesReactivityNote | Reactswithmouse.Otherspecieshavenotbeentested. |
| AntibodyType | MonoclonalAntibody |
| EntrezGeneNumber | |
| GeneSymbol |
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| PurificationMethod | ProteinGPurified |
| UniProtNumber | |
| UniProtSummary | FUNCTION:SwissProt:P55268#Bindingtocellsviaahighaffinityreceptor,lamininisthoughttomediatetheattachment,migrationandorganizationofcellsintotissuesduringembryonicdevelopmentbyinteractingwithotherextracellularmatrixcomponents. SIZE:1798aminoacids;195981Da SUBUNIT:Lamininisacomplexglycoprotein,consistingofthreedifferentpolypeptidechains(alpha,beta,gamma),whichareboundtoeachotherbydisulfidebondsintoacross-shapedmoleculecomprisingonelongandthreeshortarmswithglobulesateachend.Beta-2isasubunitoflaminin-3(S-laminin),laminin-4(S-merosin),andlaminin-7(KS-laminin). SUBCELLULARLOCATION:Secreted,extracellularspace.Note=S-lamininisconcentratedinthesynapticcleftoftheneuromuscularjunction. DOMAIN:SwissProt:P55268Thealpha-helicaldomainsIandIIarethoughttointeractwithotherlamininchainstoformacoiledcoilstructure.&DomainsVIandIVareglobular. DISEASE:SwissProt:P55268#DefectsinLAMB2arethecauseofPiersonsyndrome[MIM:609049];alsoknownasmicrocoria-congenitalnephroticsyndrome.Piersonsyndromeischaracterizedbynephroticsyndromewithneonatalonset,diffusemesangialsclerosisandeyeabnormalitieswithmicrocoriaastheleADIngclinicalfeature.Deathusuallyoccurswithinthefirstweeksoflife.Diseaseseveritydependsonthemutationtype:nontruncatingLAMB2mutationsmaydisplayvariablephenotypesrangingfromamildervariantofPiersonsyndrometoisolatedcongenitalnephroticsyndrome.&DefectsinLAMB2areacauseofcongenitalnephroticsyndrome[MIM:609049].Congenitalnephroticsyndromeconstitutesaheterogeneousgroupofconditionshavingincommonthedisruptionofnormalglomerularpermselectivity.CongenitalnephroticsyndromeduetoLAMB2mutationsmaybeassociatedwithocularabnormalities. SIMILARITY:Contains13lamininEGF-likedomains.&Contains1lamininIVtypeBdomain.&Contains1lamininN-terminaldomain. |
| MolecularWeight | ~200kDa |
| PhysicochemicalInformation |
|---|
| Dimensions |
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| MaterialsInformation |
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| MaterialsInformation |
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品牌介绍
密理博(Millipore)公司成立于1954年，总部位于美国麻省，在全世界设有47个办事处，为100多个国家提供产品和技术服务。目前全球雇员超过5800人，在美国、法国和日本等国家拥有7家大型生产工厂，主要生产过滤膜及膜过滤产品。20世纪80年代，密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构，并于2000年4月在上海浦东外高桥保税区建立了密理博（上海）贸易有限公司。为了更好地满足中国用户的需求，密理博中国主页于2006年11月向广大用户开放，介绍密理博中国有限公司的最新动态，力求为用户打造专业的产品与服务信息交流平台。
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