密理博/ABN55 |抗Netrin-1抗体/ABN55/100µ；L
市场价：
¥6360.00
美元价：
3816.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Description | |
|---|---|
| CatalogueNumber | ABN55 |
| Description | Anti-Netrin-1Antibody |
| AlternateNames |
|
| BackgroundInformation | Netrin-1isasecreted,bifunctionalligandbelongingtotheNetrinfamily;agroupofproteinsknowntoactasversatile,chemotropicaxonguidancecuesforCNScommissuralandperipheralmotoraxons.Netrin-1isnecessaryforspinalcordoligodendrocytedevelopment.TherearetworeceptorswithwhichNetrin-1isassociatedandthatwillcauseittobeeitherachemoattractantorachemorepellantforaxons.ReceptorDeletedinColorectalCancer(DCC)regulatestheattractionofaxonstoNetrin-1,andUNC5mediatesaxonrepulsionfromNetrin-1.StudieshaveshownNetrin-1tofunctionasasurvivalfactorthroughitsrelationshiptoitsreceptors,inhibitingtheonsetofapoptosis.Netrin-1hasalsobeenimplicatedincolorectaltumOrigenesisviaitsapoptoticregulatoryrole.ExpressionofNetrin-1hasbeendetectedinadultaxonsandoligodendrocytes,andisalsowidelyobservedindevelopingembryonicmesodermaltissuesandnervoussystem. |
| ProductInformation | |
|---|---|
| Format | Serum |
| Control |
|
| Presentation | Rabbitpolyclonalserumcontaining0.05%sodiumazide. |
| StorageandShippingInformation | |
|---|---|
| StorageConditions | Stablefor1yearat-20°Cfromdateofreceipt. HandlingRecommendations:Uponreceiptandpriortoremovingthecap,centrifugethevialandgentlymixthesolution.Aliquotintomicrocentrifugetubesandstoreat-20°C.Avoidrepeatedfreeze/thawcycles,whichmaydamageIgGandaffectproductperformance. |
| Applications | |
|---|---|
| Application | Anti-Netrin-1AntibodydetectslevelofNetrin-1&hasbeenpublished&validatedforuseinWB. |
| KeyApplications |
|
| BIOLOGicalInformation | |
|---|---|
| Immunogen | LinearpeptidecorrespondingtomouseNetrin-1. |
| Epitope | Unknown |
| Host | Rabbit |
| Isotype | IgG |
| SpeciesReactivity |
|
| SpeciesReactivityNote | Demonstratedtoreactwithmouseandrat.Otherhomologies:Human(94%sequencehomology). |
| AntibodyType | PolyclonalAntibody |
| EntrezGeneNumber | |
| GeneSymbol |
|
| PurificationMethod | Unpurified |
| UniProtNumber | |
| UniProtSummary | FUNCTION:NetrinscontrolguidanceofCNScommissuralaxonsandperipheralmotoraxons.ItsassociationwitheitherDCCorsomeUNC5receptorswillleadtoaxonattractionorrepulsion,respectively.Italsoserveasasurvivalfactorviaitsassociationwithitsreceptorswhichpreventtheinitiationofapoptosis.Involvedincolorectaltumorigenesisbyregulatingapoptosis(Bysimilarity). SUBUNITSTRUCTURE:Bindstoitsreceptors;DCC,UNC5A,UNC5B,UNC5CandprobablyUNC5D(Bysimilarity).Bindstoitsreceptor;DSCAM. SUBCELLULARLOCATION:Secreted›extracellularspace›extracellularmatrix TISSUESPECIFICTY:Intheembryo,widelyexpressedinthedevelopingnervoussystemandinmesodermaltissues. SEQUENCESIMILARITIES:Contains3lamininEGF-likedomains. Contains1lamininN-terminaldomain. Contains1NTRdomain. |
| MolecularWeight | ~68kDaobserved.CharacteristicproteolyticfragmentsofNetrin-1foundintheCNSrunatlowermolecularweights. |
| PhysicochemicalInformation |
|---|
| Dimensions |
|---|
| MaterialsInformation |
|---|
| MaterialsInformation |
|---|
品牌介绍
密理博(Millipore)公司成立于1954年，总部位于美国麻省，在全世界设有47个办事处，为100多个国家提供产品和技术服务。目前全球雇员超过5800人，在美国、法国和日本等国家拥有7家大型生产工厂，主要生产过滤膜及膜过滤产品。20世纪80年代，密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构，并于2000年4月在上海浦东外高桥保税区建立了密理博（上海）贸易有限公司。为了更好地满足中国用户的需求，密理博中国主页于2006年11月向广大用户开放，介绍密理博中国有限公司的最新动态，力求为用户打造专业的产品与服务信息交流平台。
联络我们
