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当前位置: 首页 > 产品中心 > Functional_antibody > Millipore/AB5699 | Anti-Cysteine-rich Motor Neuron 1 Antibody/AB5699/100 µL
商品详细Millipore/AB5699 | Anti-Cysteine-rich Motor Neuron 1 Antibody/AB5699/100 µL
Millipore/AB5699 | Anti-Cysteine-rich Motor Neuron 1 Antibody/AB5699/100 µL
Millipore/AB5699 | Anti-Cysteine-rich Motor Neuron 1 Antibody/AB5699/100 µL
商品编号: AB5699
品牌: 密理博
市场价: ¥7800.00
美元价: 4680.00
产地: 美国(厂家直采)
公司:
产品分类: 功能性抗体
公司分类: Functional_antibody
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍
Description
CatalogueNumberAB5699
BrandFamilyChemicon®
TradeName
  • Chemicon
DescriptionAnti-Cysteine-richMotorNeuron1Antibody
AlternateNames
  • CRIM1
ProductInformation
FormatSerum
PresentationRabbitserum.Liquid.
StorageandShippingInformation
StorageConditionsMaintainat-20°Cinundilutedaliquotsforupto12monthsafterdateofreceipt.Avoidrepeatedfreeze/thawcycles.
Applications
ApplicationAnti-Cysteine-richMotorNeuron1AntibodydetectslevelofCysteine-richMotorNeuron1&hasbeenpublished&validatedforuseinIP&WB.
KeyApplications
  • Immunoprecipitation
  • WesternBlotting
ApplicationNotesWesternblot:1:1,000usingECL.Theantibodyreactswithproteinsof~120kDa.Preferredgelpercentageis7.5%.SuggestedblockingbufferisPBScontaining5%non-fatmilk.SuggesteddilutionbufferisPBScontaining1%non-fatmilk.

Immunoprecipitation:5μLto1mLofcellextract.Preferredtissue/celllysisbufferisRIPA.Suggestedincubationtimeis2-4hours.SuggestedcaptureagentisProteinA.

Optimalworkingdilutionsmustbedeterminedbytheenduser.
BIOLOGicalInformation
ImmunogenRecombinantproteinfromthecytoplasmictailofmouseCrim1.
HostRabbit
SpecificityCrim1

SUBCELLULARLOCALIZATION:IntracellularandMembraneassociated.
SpeciesReactivity
  • Human
  • Mouse
AntibodyTypePolyclonalAntibody
EntrezGeneNumber
EntrezGeneSummaryMotorneuronsareamongtheearliestneuronstoappearafterthecommencementofcellpatterningandthebeginningofcelldifferentiation.Differentiationoccursinaventral-to-dorsalgrADIentandismediated,atleastinpart,bytheconcentrationofventrallyexpressedsonichedgehogprotein(SHH;MIM600725).Dorsallyexpressedfactors,suchasmembersofthebonemorphogenicprotein(e.g.,BMP4;MIM112262)andtransforminggrowthfactor-beta(e.g.,TGFB1;MIM190180)families,canrepresstheinductionoftheseneurons.CRIM1mayinteractwithgrowthfactorsimplicatedinmotorneurondifferentiationandsurvival(Kolleetal.,2000[PubMed10642437]).[suppliedbyOMIM]
GeneSymbol
  • CRIM1
  • CRIM-1
  • MGC138194
  • S52
UniProtNumber
UniProtSummaryFUNCTION:SwissProt:Q9NZV1#MayplayaroleinCNSdevelopmentbyinteractingwithgrowthfactorsimplicatedinmotorneurondifferentiationandsurvival.Mayplayaroleincapillaryformationandmaintenanceduringangiogenesis.ModulatesBMPactivitybyaffectingitsprocessinganddeliverytothecellsurface.
SIZE:1036aminoacids;113738Da
SUBUNIT:InteractswithBMP4andBMP7.
SUBCELLULARLOCATION:Processedcysteine-richmotorneuron1protein:Secreted.&Cellmembrane;Single-passtypeImembraneprotein.
TISSUESPECIFICITY:Expressedinpancreas,kidney,skeletalmuscle,lung,placenta,brain,heart,spleen,liverandsmallintestine.Expressedinbloodvessels(atproteinlevel).
PTM:N-glycosylated.
SIMILARITY:SwissProt:Q9NZV1##Contains4antistasin-likedomains.&Contains1IGFBPN-terminaldomain.&Contains6VWFCdomains.
PhysicochemicalInformation
Dimensions
MaterialsInformation
MaterialsInformation
品牌介绍
密理博(Millipore)公司成立于1954年,总部位于美国麻省,在全世界设有47个办事处,为100多个国家提供产品和技术服务。目前全球雇员超过5800人,在美国、法国和日本等国家拥有7家大型生产工厂,主要生产过滤膜及膜过滤产品。20世纪80年代,密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构,并于2000年4月在上海浦东外高桥保税区建立了密理博(上海)贸易有限公司。为了更好地满足中国用户的需求,密理博中国主页于2006年11月向广大用户开放,介绍密理博中国有限公司的最新动态,力求为用户打造专业的产品与服务信息交流平台。