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Millipore/AB5220 | Anti-Growth Associated Protein-43 (GAP-43) Antibody/AB5220/100 µL
Millipore/AB5220 | Anti-Growth Associated Protein-43 (GAP-43) Antibody/AB5220/100 µL
市场价：
¥7800.00
美元价：
4680.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Description | |
|---|---|
| CatalogueNumber | AB5220 |
| BrandFamily | Chemicon® |
| TradeName |
|
| Description | Anti-GrowthAssociatedProtein-43(GAP-43)Antibody |
| AlternateNames |
|
| BackgroundInformation | GAP-43,acommonMarkerofdifferentiatingneurons,isexpressedatelevatedlevelsbydevelopingorregeneratingneuronsduringaxongrowth.WhileGAP-43isanintegralmembraneproteinassociatedwiththecytoplasmicsurfaceofaxonalgrowthcones(andsynapses),itisabsentfromdendriticgrowthcones.Inadultbrain,GAP-43isfoundinhighconcentrationinpresynapticareaswherememoryformationisthoughttooccur,suchasfrontalcortex,limbicsystemandhippocampus.PhosphorylationofGAP-43byPKC(atSer41onhuman,mouse,rat,andbovineGAP-43orSer42onchickenandXenopusGAP-43)isspecificallycorrelatedwithcertainformsofsynapticplasticity. |
| ProductInformation | |
|---|---|
| Format | Purified |
| Control |
|
| Presentation | PurifiedrabbitpolyclonalinbuffercontainingPBSwith0.01%sodiumazideasapreservative. |
| StorageandShippingInformation | |
|---|---|
| StorageConditions | Stableforupto6monthsat-20ºCinundilutedaliquotsfromdateofreceipt. Avoidrepeatedfreeze/thawcycles.Duringshipment,smallvolumesofproductwilloccasionallybecomeentrappedinthesealoftheproductvial.Forproductswithvolumesof200µLorless,werecommendgentlytappingthevialonahardsurfaceorbrieflycentrifugingthevialinatabletopcentrifugetodislodgeanyliquidinthecontainer’scap. |
| Applications | |
|---|---|
| Application | Anti-GrowthAssociatedProtein-43(GAP-43)AntibodyisanantibodyagainstGrowthAssociatedProtein-43(GAP-43)foruseinELISA,IC,IH,IP&WB. |
| KeyApplications |
|
| ApplicationNotes | Immunohistochemistry: 1:1,000dilutionofapreviouslotwasusedon4%paraformaldehyde/PBSfixedor3%Paraformaldehyde/0.1%Gluteraldehyde/PBSfixedtissuesections. Immunocytochemistry: 1:1,000dilutionofapreviouslotwasusedonHippocampalneuronsincultureandPC12cellsstimulatedwithNGF. Immunoprecipitation: 1:100dilutionofapreviouslotwasused. ELISA: 1:2,000dilutionofapreviouslotwasused. |
| BIOLOGicalInformation | |
|---|---|
| Immunogen | RecombinantratGAP-43(completesequence). |
| Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. |
| Host | Rabbit |
| Specificity | RecognizesGrowthAssociatedProtein-43(GAP-43). |
| SpeciesReactivity |
|
| SpeciesReactivityNote | Reactstoahighdegreewithmouse.Reactstoalesserdegreewithrat,human,bovineandchicken.Otherspecieshavenotbeentested. |
| AntibodyType | PolyclonalAntibody |
| EntrezGeneNumber | |
| EntrezGeneSummary | Theproteinencodedbythisgenehasbeentermeda"growth"or"plasticity"proteinbecauseitisexpressedathighlevelsinneuronalgrowthconesduringdevelopmentandaxonalregeneration.Thisencodedproteinisconsideredacrucialcomponentofaneffectiveregenerativeresponseinthenervoussystem. |
| GeneSymbol |
|
| PurificationMethod | AmmoniumSulfatePrecipitation |
| UniProtNumber | |
| UniProtSummary | FUNCTION:SwissProt:P17677#Thisproteinisassociatedwithnervegrowth.Itisamajorcomponentofthemotilegrowthconesthatformthetipsofelongatingaxons. SIZE:238aminoacids;24803Da SUBUNIT:BindscalmodulinwithagreateraffinityintheabsenceofCa(2+)thaninitspresence(Bysimilarity). SUBCELLULARLOCATION:Cellmembrane;Peripheralmembraneprotein;Cytoplasmicside.Cellprojection,growthconemembrane;Peripheralmembraneprotein;Cytoplasmicside.Celljunction,synapse.Note=Cytoplasmicsurfaceofgrowthconeandsynapticplasmamembranes. PTM:PhosphorylationofthisproteinbyaproteinkinaseCisspecificallycorrelatedwithcertainformsofsynapticplasticity. SIMILARITY:SwissProt:P17677##Belongstotheneuromodulinfamily.&Contains1IQdomain. |
| MolecularWeight | 23.6kDa |
| PhysicochemicalInformation |
|---|
| Dimensions |
|---|
| MaterialsInformation |
|---|
| MaterialsInformation |
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品牌介绍
密理博(Millipore)公司成立于1954年，总部位于美国麻省，在全世界设有47个办事处，为100多个国家提供产品和技术服务。目前全球雇员超过5800人，在美国、法国和日本等国家拥有7家大型生产工厂，主要生产过滤膜及膜过滤产品。20世纪80年代，密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构，并于2000年4月在上海浦东外高桥保税区建立了密理博（上海）贸易有限公司。为了更好地满足中国用户的需求，密理博中国主页于2006年11月向广大用户开放，介绍密理博中国有限公司的最新动态，力求为用户打造专业的产品与服务信息交流平台。
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