Millipore/AB2253 | Anti-Doublecortin Antibody/AB2253/50 µL
市场价：
¥8220.00
美元价：
4932.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Description | |
|---|---|
| CatalogueNumber | AB2253 |
| Replaces | AB5910 |
| Description | Anti-DoublecortinAntibody |
| AlternateNames |
|
| BackgroundInformation | Doublecortin(DCX)isamicrotubule-associatedproteinexpressedalmostexclusivelyinimmatureneurons.NeuronalprecursorsbegintoexpressDCXshortlyafterexitingthecellcycle,andcontinuetoexpressDCXfor2-3weeksasthecellsmatureintoneurons.DownregulationofDCXbeginsafter2weeks,andoccursatthesametimethatthesecellsbegintoexpress,aMarkerformatureneurons.DuetothenearlyexclusiveexpressionofDCXindevelopingneurons,thisproteinhasbeenusedincreasinglyasamarkerforneurogenesis.Indeed,thelevelsofDCXexpressionincreaseinresponsetoexercise,whichoccursinparallelwithincreasedBrdUlabelling,currentlya"goldstandard"inmeasuringneurogenesis. |
| ProductInformation | |
|---|---|
| Format | Serum |
| Control |
|
| Presentation | GST-DepletedSerawith0.05%NaN3. |
| StorageandShippingInformation | |
|---|---|
| StorageConditions | Maintainat-20°Cinundilutedaliquotsforupto1yearafterdateofreceipt. |
| BIOLOGicalInformation | |
|---|---|
| Immunogen | RecombinantPeptide. |
| Epitope | C-Terminus |
| Host | GuineaPig |
| Specificity | Cat.#AB2253recognizestheC-TerminusofDoublecortin. |
| SpeciesReactivity |
|
| SpeciesReactivityNote | MouseandRat.Expectedtoreactwithhumanbasedonsequencehomology.Reactivitywithotherspecieshasnotbeendetermined. |
| AntibodyType | PolyclonalAntibody |
| EntrezGeneNumber | |
| EntrezGeneSummary | Inthedevelopingcortex,corticalneuronsmustmigrateoverlongdistancestoreachthesiteoftheirfinaldifferentiation.TheproteinencodedbythisgeneisacytoplasmicproteinwhichappearstodirectneuronalmigrationbyregulatingtheorganizationandstABIlityofmicrotubules.Theencodedproteincontainstwodoublecortindomains,whichbindmicrotubules.Inaddition,theencodedproteininteractswithLIS1,theregulatorygammasubunitofplateletactivatingfactoracetylhydrolase,andthisinteractionisimportanttopropermicrotubulefunctioninthedevelopingcortex.MutationsinthisgeneareacauseofX-linkedlissencephaly.Multipletranscriptvariantsencodingatleastthreedifferentisoformshavebeenfoundforthisgene.[providedbyRefSeq] |
| GeneSymbol |
|
| PurificationMethod | GSTDepletion |
| UniProtNumber | |
| UniProtSummary | FUNCTION:Seemstoberequiredforinitialstepsofneuronaldispersionandcortexlaminationduringcerebralcortexdevelopment.MayactbycompetingwiththeputativeneuronalproteinkinaseDCAMKL1inbindingtoatargetprotein.Mayinthatwayparticipateinasignalingpathwaythatiscrucialforneuronalinteractionbeforeandduringmigration,possIBLyaspartofacalciumion-dependentsignaltransductionpathway.MaybepartwithLIS-1ofanoverlapping,butdistinct,signalingpathwaysthatpromoteneuronalmigration. SUBUNITSTRUCTURE:Interactswithtubulin. SUBCELLULARLOCATION:Cytoplasm. TISSUESPECIFICITY:Highlyexpressedinneuronalcellsoffetalbrain(inthemajorityofcellsofthecorticalplate,intermediatezoneandventricularzone),butnotexpressedinotherfetaltissues.Intheadult,highlyexpressedinthebrainfrontallobe,butverylowexpressioninotherregionsofbrain,andnotdetectedinheart,placenta,lung,liver,skeletalmuscles,kidneyandpancreas. DISEASE:DefectsinDCXarethecauseoflissencephalyX-linkedtype1(LISX1)[MIM:300067];alsocalledX-LISorLIS.LISX1isaclassiclissencephalycharacterizedbymentalretardationandseizuresthataremoresevereinmalepatients.Affectedboysshowanabnormallythickcortexwithabsentorseverelyreducedgyri.Clinicalmanifestationsincludefeedingproblems,abnormalmusculartone,seizuresandseveretoprofoundpsychomotorretardation.Femalepatientsdisplayalessseverephenotypereferredtoas"doublecortex".Ref.1Ref.2Ref.9Ref.10Ref.18Ref.21 DefectsinDCXarethecauseofsubcorticalbandheterotopiaX-linked(SBHX)[MIM:300067];alsoknownasdoublecortexorsubcorticallaminarheterotopia(SCLH).SBHXisamildbrainmalformationofthelissencephalyspectrum.Itischaracterizedbybilateralandsymmetricplatesorbandsofgraymatterfoundinthecentralwhitematterbetweenthecortexandcerebralventricles,cerebralconvolutionsusuallyappearingnormal.Ref.11Ref.12Ref.13Ref.14Ref.15Ref.16Ref.17Ref.19 AchromosomalaberrationinvolvingDCXisfoundinlissencephaly.Translocationt(X;2)(q22.3;p25.1). SEQUENCESIMILARITY:Contains2doublecortindomains. |
| MolecularWeight | Approx.45kDa. |
| PhysicochemicalInformation |
|---|
| Dimensions |
|---|
| MaterialsInformation |
|---|
| MaterialsInformation |
|---|
品牌介绍
密理博(Millipore)公司成立于1954年，总部位于美国麻省，在全世界设有47个办事处，为100多个国家提供产品和技术服务。目前全球雇员超过5800人，在美国、法国和日本等国家拥有7家大型生产工厂，主要生产过滤膜及膜过滤产品。20世纪80年代，密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构，并于2000年4月在上海浦东外高桥保税区建立了密理博（上海）贸易有限公司。为了更好地满足中国用户的需求，密理博中国主页于2006年11月向广大用户开放，介绍密理博中国有限公司的最新动态，力求为用户打造专业的产品与服务信息交流平台。
联络我们
