密理博/AB10521 |抗神经肽-1抗体/AB10521/100µ；L
市场价：
¥6580.00
美元价：
3948.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Description | |
|---|---|
| CatalogueNumber | AB10521 |
| Description | Anti-Neuropilin-1Antibody |
| AlternateNames |
|
| BackgroundInformation | Neuropilin-1isatype1membraneproteinwiththreedistinctfunctions.First,itcanmediatecelladhesionviaaheterophilicmolecularinteraction.Second,inneuronalcells,neuropilin-1bindstheclass3semaphorins,whichareneuronalchemorepellents,andplaysaroleinthedirectionalguidanceofaxons.ItisexpectedtoformcomplexeswiththeplexinAsubfamilymembersandmediatethesemaphorin-elicitedinhibitorysignalsintoneurons.Third,inendothelialcells,neuropilin-1bindsapotentendothelialcellmitogen,vascularendothelialgrowthfactor(VEGF)165,andregulatesvesselformation. |
| ProductInformation | |
|---|---|
| Format | Serum |
| Control |
|
| Presentation | Rabbitseruminbuffercontaining0.05%sodiumazide. |
| StorageandShippingInformation | |
|---|---|
| StorageConditions | Stablefor1yearat-20°Cfromdateofreceipt. HandlingRecommendations:Uponreceiptandpriortoremovingthecap,centrifugethevialandgentlymixthesolution.Aliquotintomicrocentrifugetubesandstoreat-20°C.Avoidrepeatedfreeze/thawcycles,whichmaydamageIgGandaffectproductperformance. |
| Applications | |
|---|---|
| Application | ThisAnti-Neuropilin-1AntibodyisvalidatedforuseinWB,IH,IP,IFforthedetectionofNeuropilin-1. |
| KeyApplications |
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| BIOLOGicalInformation | |
|---|---|
| Immunogen | ThisantibodyisgeneratedfromrabbitsimmunizedwithaHis-taggedpartialrecombinantratNeuropilin-1. |
| Epitope | Unknown |
| Host | Rabbit |
| Specificity | ThisantibodyrecognizesNeuropilin-1. |
| Isotype | IgG |
| SpeciesReactivity |
|
| SpeciesReactivityNote | Proventoreactwithmouseandrat.Human-94%homology |
| AntibodyType | PolyclonalAntibody |
| EntrezGeneNumber | |
| EntrezGeneSummary | NRP1isamembrane-boundcoreceptortoatyrosinekinasereceptorforbothvascularendothelialgrowthfactor(VEGF;MIM192240)andsemaphorin(seeSEMA3A;MIM603961)familymembers.NRP1playsversatilerolesinangiogenesis,axonguidance,cellsurvival,migration,andinvasion.[suppliedbyOMIM] |
| GeneSymbol |
|
| PurificationMethod | Unpurified |
| UniProtNumber | |
| UniProtSummary | FUNCTION:Receptorinvolvedinthedevelopmentofthecardiovascularsystem,inangiogenesis,intheformationofcertainneuronalcircuitsandinorganogenesisoutsidethenervoussystem.Itmediatesthechemorepulsantactivityofsemaphorins.Itbindstosemaphorin3A,thePLGF-2isoformofPGF,theVEGF-165isoformofVEGFandVEGF-B.CoexpressionwithKDRresultsinincreasedVEGF-165bindingtoKDRaswellasincreasedchemotaxis.ItmayregulateVEGF-inducedangiogenesis(Bysimilarity). SUBUNIT:HeterodimerwithNRP2(Probable).BindsPLXNB1(Bysimilarity). SUBCELLULARLOCATION:Membrane;Single-passtypeImembraneprotein.TISSUESPECIFICITY:Foundintheembryonicnervoussystem. SIMILARITY:Belongstotheneuropilinfamily. Contains2CUBdomains. Contains2F5/8typedomains. Contains1MAMdomain. |
| MolecularWeight | 130kDa |
| PhysicochemicalInformation |
|---|
| Dimensions |
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| MaterialsInformation |
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| MaterialsInformation |
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品牌介绍
密理博(Millipore)公司成立于1954年，总部位于美国麻省，在全世界设有47个办事处，为100多个国家提供产品和技术服务。目前全球雇员超过5800人，在美国、法国和日本等国家拥有7家大型生产工厂，主要生产过滤膜及膜过滤产品。20世纪80年代，密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构，并于2000年4月在上海浦东外高桥保税区建立了密理博（上海）贸易有限公司。为了更好地满足中国用户的需求，密理博中国主页于2006年11月向广大用户开放，介绍密理博中国有限公司的最新动态，力求为用户打造专业的产品与服务信息交流平台。
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