Millipore/06-574 | Anti-TrkA Antibody/06-574/200 µg
市场价：
¥8420.00
美元价：
5052.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Description | |
|---|---|
| CatalogueNumber | 06-574 |
| Replaces | CBL770 |
| BrandFamily | Upstate |
| TradeName |
|
| Description | Anti-TrkAAntibody |
| AlternateNames |
|
| BackgroundInformation | TrkA,apparentmolecularweight140kDa,isahighaffinitynervegrowthfactor(NGF).TheTrkproto-oncogenefamilycontainsfourmembers,TrkA,TrkB,TrkC,andTrkE,whicharevariablyexpressedthroughoutthecentralandperipheralnervoussystems.TrkAbindstonervegrowthfactor(NGF)andautophosphorylatesontyrosineresidues(Tyr490,Tyr674,Tyr675,Tyr751andTyr785)toactivatemultipledownstreameffectorproteins.PhosphorylationatTyr490isrequiredforShcassociationandsubsequentactivationoftheRas-MAPkinase-signalingcascade,whichleadstoactivationofElk-1-dependentgenetranscriptionandneuritegrowth.PhosphorylationsatTyr674andTyr675liewithinthecatalyticdomainofTrkAtyrosinekinaseandreflectTrkkinaseactivity.Additionally,phosphorylationatTyr751isrequiredforPI3-kinaseassociationandactivationoftheAktsignalingcascade. |
| ProductInformation | |
|---|---|
| Format | Purified |
| Control |
|
| Presentation | PurifiedrabbitIgGinbuffercontaining0.02Mphosphatebuffer,pH7.6,0.25MNaCl,0.1%sodiumazide.Frozenat-20°C. |
| StorageandShippingInformation | |
|---|---|
| StorageConditions | Stablefor1yearat-20°Cfromdateofreceipt. HandlingRecommendations:Uponreceipt,andpriortoremovingthecap,centrifugethevialandgentlymixthesolution.Aliquotintomicrocentrifugetubesandstoreat-20°C.Avoidrepeatedfreeze/thawcycles,whichmaydamageIgGandaffectproductperformance.Note:VariABIlityinfreezertemperaturesbelow-20°Cmaycauseglycerolcontainingsolutionstobecomefrozenduringstorage. |
| BIOLOGicalInformation | |
|---|---|
| Immunogen | RabbitsimmunizedwithbacteriallyexpressedpurifiedproteincorrespondingtotheentireextracellulardomainofratTrkAreceptor. |
| Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. |
| Host | Rabbit |
| Specificity | RecognizesTrkA,Mr140kDa.Doesnotcross-reactwithTrkBorTrkC. |
| Isotype | IgG |
| SpeciesReactivity |
|
| SpeciesReactivityNote | Rat,mouseandhuman.Reactivitywithotherspecieshasnotbeenconfirmed. |
| AntibodyType | PolyclonalAntibody |
| EntrezGeneNumber | |
| EntrezGeneSummary | Thisgeneencodesamemberoftheneurotrophictyrosinekinasereceptor(NTKR)family.Thiskinaseisamembrane-boundreceptorthat,uponneurotrophinbinding,phosphorylatesitselfandmembersoftheMAPKpathway.Thepresenceofthiskinaseleadstocelldifferentiationandmayplayaroleinspecifyingsensoryneuronsubtypes.Mutationsinthisgenehavebeenassociatedwithcongenitalinsensitivitytopain,anhidrosis,self-mutilatingbehavior,mentalretardationandcancer.Alternatetranscriptionalsplicevariantsofthisgenehavebeenfound,butonlythreehavebeencharacterizedtodate. |
| GeneSymbol |
|
| PurificationMethod | ProteinAPurfied |
| UniProtNumber | |
| UniProtSummary | FUNCTION:SwissProt:P04629#Requiredforhigh-affinitybindingtonervegrowthfactor(NGF),neurotrophin-3andneurotrophin-4/5butnotbrain-derivedneurotrophicfactor(BDNF).KnownsubstratesfortheTrkreceptorsareSHC1,PI3-kinase,andPLC-gamma-1.Hasacrucialroleinthedevelopmentandfunctionofthenociceptivereceptionsystemaswellasestablishmentofthermalregulationviasweating.ActivatesERK1byeitherSHC1-orPLC-gamma-1-dependentsignalingpathway. SIZE:796aminoacids;87497Da SUBUNIT:Existsinadynamicequilibriumbetweenmonomeric(lowaffinity)anddimeric(highaffinity)structures.BindsSH2B2.InteractswithSQSTM1whichbridgesNTRK1toNGFR(Bysimilarity). SUBCELLULARLOCATION:Cellmembrane;Single-passtypeImembraneprotein(Bysimilarity).Note=EndocytosedtotheendosomesupontreatmentofcellswithNGF(Bysimilarity). TISSUESPECIFICITY:IsoformTrkA-IIisprimarilyexpressedinneuronalcells;isoformTrkA-Iisfoundinnon-neuronaltissues. PTM:Ligand-mediatedauto-phosphorylation.InteractionwithSQSTM1isphosphotyrosine-dependent. DISEASE:SwissProt:P04629#DefectsinNTRK1areacauseofcongenitalinsensitivitytopainwithanhidrosis(CIPA)[MIM:256800].CIPAischaracterizedbyacongenitalinsensitivitytopain,anhidrosis(absenceofsweating),absenceofreactiontonoxiousstimuli,self-mutilatingbehavior,andmentalretardation.ThisrareautosomalrecessivedisorderisalsoknownascongenitalsensoryneuropathywithanhidrosisorhereditarysensoryandautonomicneuropathytypeIVorfamilialdysautonomiatypeII.&ChromosomalaberrationsinvolvingNTRK1areacauseofthyroidpapillarycarcinoma(PACT)[MIM:188550].Translocationt(1;3)(q21;q11)withTFGgeneratestheTRKT3(TRK-T3)transcriptbyfusingTFGtothe3"-endofNTRK1;arearrangementwithTPM3generatestheTRKtranscriptbyfusingTPM3tothe3"-endofNTRK1.&ChromosomalaberrationsinvolvingNTRK1areacauseofthyroidpapillarycarcinoma(PACT)[MIM:188550].IntrachromosomalrearrangementthatlinkstheproteinkinasedomainofNTRK1tothe5"-endoftheTPRgeneformsthefusionproteinTRK-T1.TRK-T1isa55kDaproteinreactingwithantibodiesagainsttheC-terminusoftheNTRK1protein. SIMILARITY:SwissProt:P04629##Belongstotheproteinkinasesuperfamily.Tyrproteinkinasefamily.Insulinreceptorsubfamily.&Contains2Ig-likeC2-type(immunoglobulin-like)domains.&Contains3LRR(leucine-rich)repeats.&Contains1proteinkinasedomain....hide»seemore» |
| MolecularWeight | 140kDa |
| PhysicochemicalInformation |
|---|
| Dimensions |
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| MaterialsInformation |
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| MaterialsInformation |
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品牌介绍
密理博(Millipore)公司成立于1954年，总部位于美国麻省，在全世界设有47个办事处，为100多个国家提供产品和技术服务。目前全球雇员超过5800人，在美国、法国和日本等国家拥有7家大型生产工厂，主要生产过滤膜及膜过滤产品。20世纪80年代，密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构，并于2000年4月在上海浦东外高桥保税区建立了密理博（上海）贸易有限公司。为了更好地满足中国用户的需求，密理博中国主页于2006年11月向广大用户开放，介绍密理博中国有限公司的最新动态，力求为用户打造专业的产品与服务信息交流平台。
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