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Millipore/MABD99 | Anti-Nkx2.2 Antibody, clone 1C11/MABD99/100 µg
Millipore/MABD99 | Anti-Nkx2.2 Antibody, clone 1C11/MABD99/100 µg
市场价：
¥6360.00
美元价：
3816.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Description | |
|---|---|
| CatalogueNumber | MABD99 |
| Description | Anti-Nkx2.2Antibody,clone1C11 |
| AlternateNames |
|
| BackgroundInformation | HomeoboxproteinNkx2.2isaNK2familytranscriptionfactorthatcontainsa60AA(128to187)DNAbindinghomeobox.Nkx2.2ispartofahomeodomainproteincombinatorialcodethatspecifiesProgenitorcellidentityandneuronalfateintheventralneuraltube.Nkx2-2isrequiredfortheestablishmentofthedopaminergicprogenitordomaininmammalianventralmidbrainandSEROtonergic(5-HT)neuronsinthebrainstemandventralspinalcord.Nkx2.2isselectivelyexpressedinoligodendrocyteprogenitors(OPC)thatarisefromglialprecursorslocatedintheventralneuraltube.StudieshaveshownNkx2.2isakeyregulatorofoligodendrocytedifferentiationbyregulatingdifferentiationand/ormaturation,butnottheinitialspecificationofoligodendrocyteprogenitors. |
| ProductInformation | |
|---|---|
| Format | Purified |
| Control |
|
| Presentation | PurifiedmousemonoclonalIgG2aκinbuffercontainingPBSwith0.05%sodiumazide. |
| StorageandShippingInformation | |
|---|---|
| StorageConditions | Stablefor1yearat2-8°Cfromdateofreceipt. |
| Applications | |
|---|---|
| Application | Anti-Nkx2.2Antibody,clone1C11isahighlyspecificmousemonoclonalantibody&thattargetsNKX2.2&hasbeentestedinwesternblotting. |
| KeyApplications |
|
| BIOLOGicalInformation | |
|---|---|
| Immunogen | RecombinantproteincorrespondingtohumanNkx2.2. |
| Clone | 1C11 |
| Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. |
| Host | Mouse |
| Isotype | IgG2aκ |
| SpeciesReactivity |
|
| SpeciesReactivityNote | DemonstratedtoreactwithMouse. PredictedtoreactwithHumanbasedonimmunogendesign. |
| AntibodyType | MonoclonalAntibody |
| EntrezGeneNumber | |
| EntrezGeneSummary | Theproteinencodedbythisgenecontainsahomeoboxdomainandmaybeinvolvedinthemorphogenesisofthecentralnervoussystem.Thisgeneisfoundonchromosome20nearNKX2-4,andthesetwogenesappeartobeduplicatedonchromosome14intheformofTITF1andNKX2-8.Theencodedproteinislikelytobeanucleartranscriptionfactor.[providedbyRefSeq,Jul2008]. |
| GeneSymbol |
|
| PurificationMethod | ProteinGPurified |
| UniProtNumber | |
| UniProtSummary | FUNCTION:Actsasatranscriptionalactivator.RequiredforthemaintenanceofNEUROD1expressioninthehoromone-producingendocrinecellsofthepancreas.Maybeinvolvedinspecifyingdiencephalicneuromericboundaries,andincontrollingtheexpressionofgenesthatplayaroleinaxonalguidance.AssociateswithchromatinattheNEUROD1promoterregion.BindstoasubsetofconsensuselementswithintheNEUROD1promoter(Bysimilarity). SUBUNITSTRUCTURE:InteractswithOLIG2(Bysimilarity). SUBCELLULARLOCATION:Nucleus(Bysimilarity). DOMAIN:ThehomeodomainisessentialforinteractionwithOLIG2(Bysimilarity). SEQUENCESIMILARITIES:BelongstotheNK-2homeoboxfamily. Contains1homeoboxDNA-bindingdomain. |
| MolecularWeight | ~37kDaobserved. Uncharacterizedbandsmayappearat~25kDaand~300kDainsomelysates. |
| PhysicochemicalInformation |
|---|
| Dimensions |
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| MaterialsInformation |
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| MaterialsInformation |
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品牌介绍
密理博(Millipore)公司成立于1954年，总部位于美国麻省，在全世界设有47个办事处，为100多个国家提供产品和技术服务。目前全球雇员超过5800人，在美国、法国和日本等国家拥有7家大型生产工厂，主要生产过滤膜及膜过滤产品。20世纪80年代，密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构，并于2000年4月在上海浦东外高桥保税区建立了密理博（上海）贸易有限公司。为了更好地满足中国用户的需求，密理博中国主页于2006年11月向广大用户开放，介绍密理博中国有限公司的最新动态，力求为用户打造专业的产品与服务信息交流平台。
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