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Millipore/MAB5554 | Anti-Pax6 Antibody, clone AD1.5/MAB5554/100 µL
Millipore/MAB5554 | Anti-Pax6 Antibody, clone AD1.5/MAB5554/100 µL
市场价：
¥6780.00
美元价：
4068.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Description | |
|---|---|
| CatalogueNumber | MAB5554 |
| BrandFamily | Chemicon® |
| TradeName |
|
| Description | Anti-Pax6Antibody,cloneAD1.5 |
| ProductInformation | |
|---|---|
| Format | Ascites |
| Control |
|
| Presentation | Ascitesfluidcontainingnopreservatives. |
| StorageandShippingInformation | |
|---|---|
| StorageConditions | Maintainfor1yearat-20°Cfromdateofshipment.Aliquottoavoidrepeatedfreezingandthawing.Formaximumrecoveryofproduct,centrifugetheoriginalvialafterthawingandpriortoremovingthecap. |
| BIOLOGicalInformation | |
|---|---|
| Immunogen | RecombinanthumanPax6. |
| Clone | AD1.5 |
| Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. |
| Host | Mouse |
| Specificity | RecognizesPax6. |
| Isotype | IgG1 |
| SpeciesReactivity |
|
| AntibodyType | MonoclonalAntibody |
| EntrezGeneNumber | |
| EntrezGeneSummary | Thisgeneencodespairedboxgene6,oneofmanyhumanhomologuesoftheDrosophilamelanogastergeneprd.Inadditiontothehallmarkfeatureofthisgenefamily,aconservedpairedboxdomain,theencodedproteinalsocontainsahomeoboxdomain.BothdomainsareknowntobindDNA,andfunctionasregulatorsofgenetranscription.Thisgeneisexpressedinthedevelopingnervoussystem,andindevelopingeyes.MutationsinthisgeneareknowntocauseaniridiaaswellasPeter"sanomaly,bothoculardiseases. |
| GeneSymbol |
|
| PurificationMethod | Unpurified |
| UniProtNumber | |
| UniProtSummary | FUNCTION:SwissProt:P26367#Transcriptionfactorwithimportantfunctionsinthedevelopmentoftheeye,nose,centralnervoussystemandpancreas.Requiredforthedifferentiationofpancreaticisletalphacells(Bysimilarity).CompeteswithPAX4inbindingtoacommonelementintheglucagon,insulinandsomatostatinpromoters.RegulatesspecificationoftheventralneuronsubtypesbyestablishingthecorrectProgenitordomains(Bysimilarity).Isoform5aappearstofunctionasamolecularswitchthatspecifiestargetgenes. SIZE:422aminoacids;46683Da SUBCELLULARLOCATION:Nucleus. TISSUESPECIFICITY:Fetaleye,brain,spinalcordandolfactoryepithelium.Isoform5aislessabundantthanthePAX6shorterform. DEVELOPMENTALSTAGE:Expressedinthedevelopingeyeandbrain. DISEASE:SwissProt:P26367#DefectsinPAX6arethecauseofaniridiatypeII(AN2)[MIM:106210].AN2isabilateralpanoculardisordercharacterizedbycompleteorpartialabsenceoftheiris,absenceofthefoveaandmalformationsofthelensandanteriorchamber.Severeage-relatedcornealdegenerationisafrequentcomplicationwhichcontributestoapoorvisualprognostisinaniridia.AboutonethirdofthecasesaresporADIc,andtwothirdsarefamilial,withautosomaldominantinheritanceandhighpenetrance.NearlyonethirdofsporadicANpatientsdevelopWilmstumorinassociationwithgenitourinaryanomaliesandmentalretardation(WAGRsyndrome)asaconsequenceofheterozygous(sub)microscopicdeletionsofchromosome11p13.&DefectsinPAX6areacauseofPetersanomaly[MIM:604229].Petersanomalyconsistsofacentralcornealleukoma,absenceoftheposteriorcornealstromaandDescemetmembrane,andavariabledegreeofirisandlenticularattachmentstothecentralaspectoftheposteriorcornea.&DefectsinPAX6areacauseofectopiapupillae[MIM:129750].Itisacongenitaleyemalformationinwhichthepupilsaredisplacedfromtheirnormalcentralposition.&DefectsinPAX6areacauseoffovealhypoplasia[MIM:136520].Fovealhypoplasiacanbeisolatedorassociatedwithpresenilecataract.Inheritanceisautosomaldominant.&DefectsinPAX6areacauseofautosomaldominantkeratitis[MIM:148190].Itisaneyedisordercharacterizedbycornealopacificationandvascularization,andbyfovealhypoplasia.&DefectsinPAX6areacauseofocularcoloboma[MIM:120200];alsoknownasuveoretinalcolobomaorcolobomaofiris,choroidandretina.Ocularcolobomasareasetofmalformationsresultingfromabnormalmorphogenesisoftheopticcupandstalk,andthefusionofthefetalfissure(opticfissure).Severecolobomatousmalformationsmaycauseasmuchas10%ofthechildhoodblindness.Theclinicalpresentationofocularcolobomaisvariable.Someindividualsmaypresentwithminimaldefectsintheanterioririsleafwithoutotheroculardefects.Morecomplexmalformationscreateacombinationofiris,uveoretinaland/oropticnervedefectswithoutorwithmicrophthalmiaorevenanophthalmia.&DefectsinPAX6areacauseofcolobomaofopticnerve[MIM:120430].&DefectsinPAX6areacauseofbilateralopticnervehypoplasia[MIM:165550];alsoknownasbilateralopticnerveaplasia.Inheritanceisautosomaldominant. SIMILARITY:SwissProt:P26367##Belongstothepairedhomeoboxfamily.&Contains1homeoboxDNA-bindingdomain.&Contains1paireddomain. |
| MolecularWeight | 46&48kDa |
| PhysicochemicalInformation |
|---|
| Dimensions |
|---|
| MaterialsInformation |
|---|
| MaterialsInformation |
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品牌介绍
密理博(Millipore)公司成立于1954年，总部位于美国麻省，在全世界设有47个办事处，为100多个国家提供产品和技术服务。目前全球雇员超过5800人，在美国、法国和日本等国家拥有7家大型生产工厂，主要生产过滤膜及膜过滤产品。20世纪80年代，密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构，并于2000年4月在上海浦东外高桥保税区建立了密理博（上海）贸易有限公司。为了更好地满足中国用户的需求，密理博中国主页于2006年11月向广大用户开放，介绍密理博中国有限公司的最新动态，力求为用户打造专业的产品与服务信息交流平台。
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