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Millipore/MAB5324 | Anti-Polysialic Acid-NCAM Antibody, clone 2-2B/MAB5324/50 µL
Millipore/MAB5324 | Anti-Polysialic Acid-NCAM Antibody, clone 2-2B/MAB5324/50 µL
市场价：
¥8840.00
美元价：
5304.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Description | |
|---|---|
| CatalogueNumber | MAB5324 |
| BrandFamily | Chemicon® |
| TradeName |
|
| Description | Anti-PolysialicAcid-NCAMAntibody,clone2-2B |
| AlternateNames |
|
| BackgroundInformation | Polysialicacid(PSA)isalong,linearhomopolymerthatisattachedtotheneuralcelladhesionmolecule(NCAM).IthastheremarkableABIlitytodown-regulateawidevarietyofcontact-dependentcellinteractions.Thisactivityisbelievedtostemfromtheabilityofthechargedpolymertooccupyalargehydratedvolumeandtherebycauseadirectphysicalhindranceofcell–cellcontact.TheregulatedexpressionofPSAhasbeenshowntopromoteareductionincellinteractionsthatcancreatepermissiveconditionsforchangesinthestructureofavarietyoftissues. ThebroadestexpressionofPSAoccursonprecursorcellsduringearlydevelopmentandplaysaroleinpromotionofthemigrationofthesecellsaftercelldivision.Inmostcases,PSAexpressionislostafterthemigrationprocessiscompleted.However,theaxonsofneuronsoftenretainPSAtobundle,sprout,andbranchappropriatelyduringaxonpath-finding. |
| ProductInformation | |
|---|---|
| Format | Ascites |
| Control |
|
| Presentation | MousemonoclonalIgMinbuffercontaining50%glycerol,nopreservatives. |
| StorageandShippingInformation | |
|---|---|
| StorageConditions | Stablefor1yearat-20ºCinundilutedaliquotsfromdateofreceipt. HandlingRecommendations:Uponreceipt,andpriortoremovingthecap,centrifugethevialandgentlymixthesolution.Aliquotintomicrocentrifugetubesandstoreat-20°C.Avoidrepeatedfreeze/thawcycles,whichmaydamageIgMandaffectproductperformance.Note:Variabilityinfreezertemperaturesbelow-20°Cmaycauseglycerolcontainingsolutionstobecomefrozenduringstorage. |
| Applications | |
|---|---|
| Application | DetectPolysialicAcid-NCAMusingthisAnti-PolysialicAcid-NCAMAntibody,clone2-2BvalidatedforuseinIC,IH,RIA&WBwithmorethan30productcitations. |
| KeyApplications |
|
| ApplicationNotes | WesternBlotting:A1:500-1:1,000concentrationofapreviouslotwasusedinWB. Immunocyto/histochemistry:A1:200-1:400dilutionofapreviouslotofthisantibodyworkedonliveandfixedcells,tissuesectionseitherfrozenorfixedwithanykindoffixative.(Rougonetal.,1986;Theodosisetal.,1991,1999).Itisnotrecommendthattheantibodybeusedonparaffinembeddedtissuesinceitgivesvariableresults. Radioimmunoassay(RIA): ApreviouslotofthisantibodywasusedinRIA.(Figarella-Brangeretal.,1996) Cellsortingandcellpanning(Ben-Huretal.,1998) Optimalworkingdilutionsmustbedeterminedbyenduser. |
| BIOLOGicalInformation | |
|---|---|
| Immunogen | ViableMeningococcusgroupB(strain355). |
| Clone | 2-2B |
| Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. |
| Host | Mouse |
| Specificity | Reactswithalpha2-8linkedneuraminicacid(NeuAc-alpha2-8)nwithn>10.Thispolymerisusuallytermedpolysialicacid(PSA).InvertebratesPSAislinkedtoneuralcelladhesionmolecule(NCAM,CD56),inbacteriaitisassociatedwithcapsulaofmeningococcusstraingroupB. |
| Isotype | IgM |
| SpeciesReactivity |
|
| SpeciesReactivityNote | ThemonoclonalworkswellonallspeciesexpressingPSA-NCAMincludingmouse. |
| AntibodyType | MonoclonalAntibody |
| EntrezGeneNumber | |
| GeneSymbol |
|
| PurificationMethod | Unpurified |
| UniProtNumber | |
| UniProtSummary | FUNCTION:SwissProt:P13592#Thisproteinisacelladhesionmoleculeinvolvedinneuron-neuronadhesion,neuritefasciculation,outgrowthofneurites,etc.|P13591#Thisproteinisacelladhesionmoleculeinvolvedinneuron-neuronadhesion,neuritefasciculation,outgrowthofneurites,etc. SIZE:761aminoacids;83770Da SUBCELLULARLOCATION:Cellmembrane;Lipid-anchor,GPI-anchor. DOMAIN:SwissProt:P13592 SIMILARITY:SwissProt:P13592##Contains2fibronectintype-IIIdomains.&Contains5Ig-likeC2-type(immunoglobulin-like)domains.|P13591##Contains2fibronectintype-IIIdomains.&Contains5Ig-likeC2-type(immunoglobulin-like)domains. |
| MolecularWeight | 150-300kDa |
| PhysicochemicalInformation |
|---|
| Dimensions |
|---|
| MaterialsInformation |
|---|
| MaterialsInformation |
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品牌介绍
密理博(Millipore)公司成立于1954年，总部位于美国麻省，在全世界设有47个办事处，为100多个国家提供产品和技术服务。目前全球雇员超过5800人，在美国、法国和日本等国家拥有7家大型生产工厂，主要生产过滤膜及膜过滤产品。20世纪80年代，密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构，并于2000年4月在上海浦东外高桥保税区建立了密理博（上海）贸易有限公司。为了更好地满足中国用户的需求，密理博中国主页于2006年11月向广大用户开放，介绍密理博中国有限公司的最新动态，力求为用户打造专业的产品与服务信息交流平台。
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