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Millipore/MAB5272 | Anti-Neural Cell Adhesion Molecule L1 Antibody, clone 324/MAB5272/100 µg
Millipore/MAB5272 | Anti-Neural Cell Adhesion Molecule L1 Antibody, clone 324/MAB5272/100 µg
市场价：
¥7800.00
美元价：
4680.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Description | |
|---|---|
| CatalogueNumber | MAB5272 |
| BrandFamily | Chemicon® |
| TradeName |
|
| Description | Anti-NeuralCellAdhesionMoleculeL1Antibody,clone324 |
| AlternateNames |
|
| BackgroundInformation | Familiesofadhesionmoleculeswhichsharecommoncarbohydratedomainsdoexist,despitethestructuralandfunctionaldiversityoftheseglycoproteins.TheseincludetheCa2+-independentneuraladhesionmolecules:N-CAM,myelinassociatedglycoprotein(MAG)andL1.L1isinvolvedinneuron-neuronadhesion,neuritefasciculation,outgrowthofneurites,cerebellargranulecellmigration,neuriteoutgrowthonSchwanncellsandinteractionsamongepithelialcellsofintestinalcrypts |
| ProductInformation | |
|---|---|
| Format | Purified |
| Control |
|
| Presentation | Ratmonoclonalinbuffercontaining0.02MPhosphatebuffer,0.25MNaCl,pH7.6with0.1%sodiumazide. |
| StorageandShippingInformation | |
|---|---|
| StorageConditions | Stablefor1yearat2-8ºCfromdateofreceipt. |
| Applications | |
|---|---|
| Application | ThisAnti-NeuralCellAdhesionMoleculeL1Antibody,clone324isvalidatedforuseinIC,IH,WBforthedetectionofNeuralCellAdhesionMoleculeL1. |
| KeyApplications |
|
| ApplicationNotes | Westernblotting: 20μg/mLwasusedonapreviouslot. Immunocytochemistry: 5-10μg/mLwasusedonapreviouslot.Cellsmustbefixedwithmethanolfor10minutesat-20°Cinthemiddlelogphase. Immunohistochemistry:Clone324issensitivetofixation.Freshfrozen,acetoneor-20Cmethanolfixedtissuesarerecommended.TrADItional4%PFAtypicallydoesnotworkwell.Otherfixativeshavenotbeentested. Optimalworkingdilutionsmustbedeterminedbyenduser. |
| BIOLOGicalInformation | |
|---|---|
| Immunogen | Ratswereimmunizedwithaglycoproteinfractionfromcerebellumof8-10dayoldC57BL/6Jmice. |
| Clone | 324 |
| Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. |
| Host | Rat |
| Specificity | MonoclonalantibodyagainstneuralcelladhesionmoleculeL1fromrat-rathybridcells. |
| Isotype | IgG |
| SpeciesReactivity |
|
| AntibodyType | MonoclonalAntibody |
| EntrezGeneNumber | |
| EntrezGeneSummary | ThisgeneisamemberoftheIgsuperfamilyandencodesacellsurfacesialoglycoproteinexpressedbycytokine-activatedendothelium.ThistypeImembraneproteinmediatesleukocyte-endothelialcelladhesionandsignaltransduction,andmayplayaroleinthedevelopmentofartherosclerosisandrheumatoidarthritis.Twoalternativelysplicedtranscriptsencodingdifferentisoformshavebeendescribedforthisgene. |
| GeneSymbol |
|
| PurificationMethod | ProteinAPurfied |
| UniProtNumber | |
| UniProtSummary | FUNCTION:SwissProt:P19320#Importantincell-cellrecognition.Appearstofunctioninleukocyte-endothelialcelladhesion.Interactswiththebeta-1integrinVLA4onleukocytes,andmediatesbothadhesionandsignaltransduction.TheVCAM1/VLA4interactionmayplayapathophysiologicrolebothinimmuneresponsesandinleukocyteemigrationtositesofinflammation. SIZE:739aminoacids;81276Da SUBCELLULARLOCATION:Membrane;Single-passtypeImembraneprotein. TISSUESPECIFICITY:Expressedoninflamedvascularendothelium,aswellasonmacrophage-likeanddendriticcelltypesinbothnormalandinflamedtissue. DOMAIN:SwissProt:P19320EitherthefirstorthefourthIg-likeC2-typedomainisrequiredforVLA4-dependentcelladhesion. PTM:Sialoglycoprotein. DISEASE:SwissProt:P19320#Mayplayanimportantroleinthegenesisofatherosclerosisandrheumatoidarthritis. SIMILARITY:Contains7Ig-likeC2-type(immunoglobulin-like)domains. |
| MolecularWeight | 120-140kDa |
| PhysicochemicalInformation |
|---|
| Dimensions |
|---|
| MaterialsInformation |
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| MaterialsInformation |
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品牌介绍
密理博(Millipore)公司成立于1954年，总部位于美国麻省，在全世界设有47个办事处，为100多个国家提供产品和技术服务。目前全球雇员超过5800人，在美国、法国和日本等国家拥有7家大型生产工厂，主要生产过滤膜及膜过滤产品。20世纪80年代，密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构，并于2000年4月在上海浦东外高桥保税区建立了密理博（上海）贸易有限公司。为了更好地满足中国用户的需求，密理博中国主页于2006年11月向广大用户开放，介绍密理博中国有限公司的最新动态，力求为用户打造专业的产品与服务信息交流平台。
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