密理博/MAB365 |抗神经生长因子受体抗体,细胞外,克隆192 IgG/MAB365/50µ;G
市场价:
¥6980.00
美元价:
4188.00
产品分类:
功能性抗体
公司分类:
Functional_antibody
联系Q Q:
3392242852
电话号码:
4000-520-616
电子邮箱:
info@ebiomall.com
商品介绍
Description | |
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CatalogueNumber | MAB365 |
Replaces | 04-1111 |
BrandFamily | Chemicon® |
TradeName |
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Description | Anti-NerveGrowthFactorReceptorAntibody,extracellular,clone192-IgG |
AlternateNames |
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BackgroundInformation | ThelowaffinityNGFR(Nervegrowthfactorreceptor)isa75kDamembrane-spanningglycoproteinlackingintrinsictyrosinekinaseactivity.p75NGFRinteractswithTrkA,thehighaffinityNGFreceptorandpotentiatesTrkAsignalingatlowNGFconcentrations.Thep75receptorbindsnervegrowthfactor,brain-derivedneurotrophicfactor,neurotrophin-3andneurotrophin-4withvaryingspecificities.Thep75NGFRplaysanimportantroleinneurotrophicfactorsignalingandhasbeenshowntomodulatethesusceptibilityofselectivecellularpopulationstoprogrammedcelldeath.ItisexpressedonmanyneuronalcellstypesincludingmanyembryonicformsandthereceptorcanbeusedtoisolateneuronalProgenitorcells. |
ProductInformation | |
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Format | Purified |
Control |
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Presentation | MousemonoclonalIgG1in0.02MPhosphatebuffer,pH7.6,0.25MNaClwith0.1%sodiumazide |
StorageandShippingInformation | |
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StorageConditions | Stablefor1yearat2-8ºCfromdateofreceipt. |
BIOLOGicalInformation | |
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Immunogen | n-octoglucosidestABIlizedproteinscontainingp75receptor,whichwereisolatedfromplasmamembranesofPC-12cells(Chandleretal.,1984). |
Epitope | Extracellular |
Clone | 192-IgG |
Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. |
Host | Mouse |
Specificity | SpecificfortheratlowaffinityNerveGrowthFactor-Receptor(p75),doesnotreactwithhumanormousep75. |
Isotype | IgG1 |
SpeciesReactivity |
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SpeciesReactivityNote | Reactswithratp75protein. |
AntibodyType | MonoclonalAntibody |
EntrezGeneNumber | |
EntrezGeneSummary | Nervegrowthfactorreceptorcontainsanextracellulardomaincontainingfour40-aminoacidrepeatswith6cysteineresiduesatconservedpositionsfollowedbyaserine/threonine-richregion,asingletransmembranedomain,anda155-aminoacidcytoplasmicdomain.Thecysteine-richregioncontainsthenervegrowthfactorbindingdomain. |
GeneSymbol |
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PurificationMethod | ProteinAPurfied |
UniProtNumber | |
UniProtSummary | FUNCTION:SwissProt:P08138#LowaffinityreceptorwhichcanbindtoNGF,BDNF,NT-3,andNT-4.Canmediatecellsurvivalaswellascelldeathofneuralcells. SIZE:427aminoacids;45183Da SUBUNIT:Homodimer;disulfide-linked.Interactswithp75NTR-associatedcelldeathexecutor.InteractswithTRAF2,TRAF4,TRAF6,PTPN13andRANBP9.InteractsthroughTRAF6withSQSTM1whichbridgesNGFRtoNTRK1.InteractswithBEX1andNGFRAP1/BEX3. SUBCELLULARLOCATION:Membrane;Single-passtypeImembraneprotein. DOMAIN:SwissProt:P08138DeathdomainisresponsIBLeforinteractionwithRANBP9. PTM:N-andO-glycosylated.&O-linkedglycansconsistofGal(1-3)GalNAccoreelongatedby1or2NeuNAc.&Phosphorylatedonserineresidues. SIMILARITY:Contains1deathdomain.&Contains4TNFR-Cysrepeats. |
MolecularWeight | 75kDa |
PhysicochemicalInformation |
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Dimensions |
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MaterialsInformation |
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MaterialsInformation |
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品牌介绍
密理博(Millipore)公司成立于1954年,总部位于美国麻省,在全世界设有47个办事处,为100多个国家提供产品和技术服务。目前全球雇员超过5800人,在美国、法国和日本等国家拥有7家大型生产工厂,主要生产过滤膜及膜过滤产品。20世纪80年代,密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构,并于2000年4月在上海浦东外高桥保税区建立了密理博(上海)贸易有限公司。为了更好地满足中国用户的需求,密理博中国主页于2006年11月向广大用户开放,介绍密理博中国有限公司的最新动态,力求为用户打造专业的产品与服务信息交流平台。
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