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Millipore/AB5622 | Anti-Microtubule-Associated Protein 2 (MAP2) Antibody/AB5622/100 µL
Millipore/AB5622 | Anti-Microtubule-Associated Protein 2 (MAP2) Antibody/AB5622/100 µL
市场价：
¥8420.00
美元价：
5052.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Description | |
|---|---|
| CatalogueNumber | AB5622 |
| BrandFamily | Chemicon® |
| TradeName |
|
| Description | Anti-Microtubule-AssociatedProtein2(MAP2)Antibody |
| AlternateNames |
|
| BackgroundInformation | Themicrotubule-associatedprotein2(MAP2)isanabundantneuronalcytoskeletalproteinthatbindstotubulinandstABIlizesmicrotubules.(HerzogandWeber,1978).MAP2isessentialforthedevelopmentandmaitenanceofneuronalmorphology(Matus,1991).InneuronsMAP2occursasthreeprimaryisoforms,thehighmolecularweightMAP2a,MAP2b,andthelowmolecularweightMAP2c,thatresultfromalternativesplicingoftheMAP2gene(Chungetal.,1996).Thelowmolecularweightisoform,MAP2c,isexpressedindevelopingbrainandisdown-regulatedduringbrainmaturation,whereasthehighmolecularweightMAP2bisexpressedinbothdevelopingandadultbrain.TheMAP2aappearsonlyafterbrainmaturation(Tucker,1990).Alltheseformsbindtomicrotubulesthroughadomainnearthecarboxylterminusthatcontainseitherthreeorfoursimilarrepeatsofa31-amino-acidmotif(Lewisetal.,1988).MAP2togetherwithMAP4andtauproteinsbelongtothefamilyofThermostableproteinsassociatedwithmicrotubules. |
| ProductInformation | |
|---|---|
| Format | Purified |
| Control |
|
| Presentation | PurifiedrabbitpolyclonalinbuffercontainingPBSwith0.1%sodiumazideasapreservative. |
| StorageandShippingInformation | |
|---|---|
| StorageConditions | Maintainat-20ºCinundilutedaliquotsforupto6monthsafterdateofreceipt.Avoidrepeatedfreeze/thawcycles. |
| Applications | |
|---|---|
| Application | DetectMicrotubule-AssociatedProtein2(MAP2)usingthisAnti-Microtubule-AssociatedProtein2(MAP2)AntibodyvalidatedforuseinELISA,IC,IH,IH(P)&WBwithmorethan55productcitations. |
| KeyApplications |
|
| ApplicationNotes | Immunocytochemistry: 1:1,000dilutionofapreviouslotwasusedonprimaryneurons. Immunohistochemistry: 1:1,000dilutionon4%paraformaldehyde/PBSfixedtissuesections. Immunoblot: 1:2,000dilutionwasusedonapreviouslot.RecognizesMAP2A(280-300kDa,andMAP2B(270-280KDa),andtoalesserextentMAP2C(70kDa)andMAP2D(70-75kDa). ELISA: greaterthanorequalto1:2,000dilutionofapreviouslotwasused. Optimalworkingdilutionsmustbedeterminedbytheenduser. |
| BIOLOGicalInformation | |
|---|---|
| Immunogen | PurifiedMicrotubule-associatedproteinfromratbrain. |
| Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. |
| Host | Rabbit |
| Specificity | SpecificforMicrotubule-associatedprotein2(MAP2).TheantibodyrecognizesallMAP2isoforms(MAP2A,MAP2B,MAP2CandMAP2D).ItshowsgreatestimmunoreactivitywiththeHMW-MAP2(MAP2AandMAP2B). |
| SpeciesReactivity |
|
| SpeciesReactivityNote | Human,mouseandrat.Reactivitywithotherspecieshasnotbeendetermined. |
| AntibodyType | PolyclonalAntibody |
| EntrezGeneNumber | |
| EntrezGeneSummary | Thisgeneencodesaproteinthatbelongstothemicrotubule-associatedproteinfamily.Theproteinsofthisfamilyarethoughttobeinvolvedinmicrotubuleassembly,whichisanessentialstepinneurogenesis.Theproductsofsimilargenesinratandmouseareneuron-specificcytoskeletalproteinsthatareenrichedindentrites,implicatingaroleindeterminingandstabilizingdentriticshapeduringneurondevelopment.Anumberofalternativelysplicedvariantsencodingdistinctisformshavebeendescribed. |
| GeneSymbol |
|
| PurificationMethod | AmmoniumSulfatePrecipitation |
| UniProtNumber | |
| UniProtSummary | FUNCTION:SwissProt:P11137#TheexactfunctionofMAP2isunknownbutMAPsmaystabilizethemicrotubulesagainstdepolymerization.Theyalsoseemtohaveastiffeningeffectonmicrotubules. SIZE:1827aminoacids;199539Da PTM:MAP2A/cisphosphorylated.PhosphorylateduponDNAdamage,probablybyATMorATR. SIMILARITY:SwissProt:P11137##Contains3Tau/MAPrepeats. |
| MolecularWeight | Approx.280kDadoublet(MAP2aandMAP2b)andapprox.70kDadoublet(MAP2c)onSDS-PAGE. |
| PhysicochemicalInformation |
|---|
| Dimensions |
|---|
| MaterialsInformation |
|---|
| MaterialsInformation |
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品牌介绍
密理博(Millipore)公司成立于1954年，总部位于美国麻省，在全世界设有47个办事处，为100多个国家提供产品和技术服务。目前全球雇员超过5800人，在美国、法国和日本等国家拥有7家大型生产工厂，主要生产过滤膜及膜过滤产品。20世纪80年代，密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构，并于2000年4月在上海浦东外高桥保税区建立了密理博（上海）贸易有限公司。为了更好地满足中国用户的需求，密理博中国主页于2006年11月向广大用户开放，介绍密理博中国有限公司的最新动态，力求为用户打造专业的产品与服务信息交流平台。
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