微孔/AB5454 |抗TUC-4蛋白抗体/AB5454/100µ；L
市场价：
¥6980.00
美元价：
4188.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Description | |
|---|---|
| CatalogueNumber | AB5454 |
| BrandFamily | Chemicon® |
| TradeName |
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| Description | Anti-TUC-4ProteinAntibody |
| AlternateNames |
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| BackgroundInformation | TUC(TOAD[TurnedOnAfterDivision]/Ulip/CRMP)isafamilyofproteinsthathaveemergedasstrongcandidatesforaroleinneuronalgrowthconesignaling.TheTUC-4familymembersreachtheirhighestexpressionlevelsinearlypost-mitoticneuronsduringtheirpeakperiodsofaxonalgrowth.TUC-4isnotexpressedinneuralProgenitorsoradultneurons(withminorexception).DatasuggeststhatTUC-4playsaroleinaxonaloutgrowth,pathfindingandpossIBLyintheprocessthatpermitsgrowingaxonstochooseproperroutesandtargets(Quinn,1999).TheTUC-4proteinisexpressedprimarilywithinthecytoplasmofpostmitoticneuronsastheybegintheirmigrationoutoftheventricularzoneintothedevelopingcorticalplate(Minturn,1995a).TUC-4isexpressedinneuronalcellbodies,neurites,andalongthemostdistalregionsofneuronalgrowthcones,includingthelamellipodiaandfilopodia(Minturn,1995b).ExpressionofTUC-4isobservedbydayE12inratscoincidentwiththeexpressionoftheearlyneuronalMarkerclassIIIbeta-tubulin(Quinn,1999).TUC-4expressionisrarelyobservedinneuronalcellsexpressingthemitoticmarkerPCNA(Minturn,1995a).TheexpressionofTUC-4hasbeenshowntobeupregulatedinresponsetoNGFinrats(Minturn,1995b)andinresponsetoretinoicacidinahumanneuroblastomacellline(SMS-KCNR;Gaetano,1997). |
| ProductInformation | |
|---|---|
| Format | Serum |
| Control |
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| Presentation | RabbitSerum.Liquidcontaining0.2%sodiumazide. |
| StorageandShippingInformation | |
|---|---|
| StorageConditions | Maintainfor6monthsat-20°Cfromdateofshipment.Aliquottoavoidrepeatedfreezingandthawing.Formaximumrecoveryofproduct,centrifugetheoriginalvialafterthawingandpriortoremovingthecap. |
| BIOLOGicalInformation | |
|---|---|
| Immunogen | Syntheticpeptidecorrespondingtoaminoacids499to511ofTUC-4aandaminoacids612-624ofTUC-4b(YDGPVFDLTTTPK) |
| Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. |
| Host | Rabbit |
| Specificity | SpecificallyrecognizestheTUC-4(Ulip-1/CRMP-4/DRP-3)splicevariants,TUC-4a(64kDa)andtheN-terminallyextendedTUC-4b(75kDa)(Quinn,2003).AB5454hasbeenreportedtolabelearlypostmitoticneuronsinprenatalratbrain.Labelingisobservedprimarilywithinthecytoplasmalongthemostdistalregionsofneuronalgrowthconesincludinglamellipodiaandfilopodia.TheantibodyisnotreactivewiththeproteinsTUC-1(Ulip-3/CRMP-1),TUC-2(Ulip-2/CRMP-2)orTUC-3(Ulip-4/CRMP-3).ItdoesnotlabelneuralprogenitorsorrADIalglia. |
| SpeciesReactivity |
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| AntibodyType | PolyclonalAntibody |
| EntrezGeneNumber | |
| GeneSymbol |
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| PurificationMethod | Unpurified |
| UniProtNumber | |
| UniProtSummary | FUNCTION:SwissProt:Q14195#Mayregulatevesiclefunctioninthegrowthcone(Bysimilarity). SIZE:570aminoacids;61963Da SUBUNIT:Interactswithsynapticvesicleprotein2andSH3Adomainofintersectin(Bysimilarity). SUBCELLULARLOCATION:Cytoplasm(Bysimilarity).Cellprojection,growthcone(Bysimilarity).Note=Colocalizeswithsynapticvesicleprotein2inthecentralregionofthegrowthcone(Bysimilarity). TISSUESPECIFICITY:Mainlyinheartandskeletalmuscle.Alsoexpressedstronglyinfetalbrainandspinalcord. SIMILARITY:SwissProt:Q14195##Belongstothedehydropyrimidinasefamily. |
| MolecularWeight | 64&74kDa |
| PhysicochemicalInformation |
|---|
| Dimensions |
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| MaterialsInformation |
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| MaterialsInformation |
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品牌介绍
密理博(Millipore)公司成立于1954年，总部位于美国麻省，在全世界设有47个办事处，为100多个国家提供产品和技术服务。目前全球雇员超过5800人，在美国、法国和日本等国家拥有7家大型生产工厂，主要生产过滤膜及膜过滤产品。20世纪80年代，密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构，并于2000年4月在上海浦东外高桥保税区建立了密理博（上海）贸易有限公司。为了更好地满足中国用户的需求，密理博中国主页于2006年11月向广大用户开放，介绍密理博中国有限公司的最新动态，力求为用户打造专业的产品与服务信息交流平台。
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