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当前位置: 首页 > 产品中心 > Functional_antibody > 密理博/AB2283 |抗Tbr2抗体/AB2283/100µ;G
商品详细密理博/AB2283 |抗Tbr2抗体/AB2283/100µ;G
密理博/AB2283 |抗Tbr2抗体/AB2283/100µ;G
密理博/AB2283 |抗Tbr2抗体/AB2283/100µ;G
商品编号: AB2283
品牌: 密理博
市场价: ¥7400.00
美元价: 4440.00
产地: 美国(厂家直采)
公司:
产品分类: 功能性抗体
公司分类: Functional_antibody
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍
Description
CatalogueNumberAB2283
DescriptionAnti-Tbr2Antibody
AlternateNames
  • eomesodermin(Xenopuslaevis)homolog
  • eomesoderminhomolog(Xenopuslaevis)
  • tbox,brain,2
BackgroundInformationTbr2(aT-domaintranscriptionfactor)isamemberofaconservedproteinfamilythatsharesacommonDNA-bindingdomain,theT-box.T-boxgenesencodetranscriptionfactorsinvolvedintheregulationofdevelopmentalprocesses.Trb2hasbeenshowntoplayaroleinthedevelopmentoftheneocortexandfunctionsinthedifferentiationpathwayofrADIalgliatopostmitoticprojectionneuron.
ProductInformation
FormatAffinityPurified
Control
  • HumanBrainTissue
PresentationPurifiedrabbitpolyclonalinbuffercontaining0.1MTris-Glycine(pH7.4,150mMNaCl)with0.05%sodiumazide.
StorageandShippingInformation
StorageConditionsStablefor1yearat2-8°Cfromdateofreceipt.
Applications
ApplicationThisAnti-Tbr2AntibodyisvalidatedforuseinIHforthedetectionofTbr2.
KeyApplications
  • Immunohistochemistry
BIOLOGicalInformation
ImmunogenKLH-conjugatedlinearpeptidecorrespondingtomouseTbr2.
EpitopeInternalDomain
ConcentrationPleaserefertotheCertificateofAnalysisforthelot-specificconcentration.
HostRabbit
SpecificityThisantibodyrecognizesTbr2.
SpeciesReactivity
  • Mouse
  • Human
SpeciesReactivityNoteProventoreactwithhumanandmouse.
AntibodyTypePolyclonalAntibody
EntrezGeneNumber
GeneSymbol
  • eomes
  • TBR2
  • eomesodermin
  • tbr1
PurificationMethodAffinityPurfied
UniProtNumber
UniProtSummaryFUNCTION:Functionsasatranscriptionalactivatorplayingacrucialroleduringdevelopment.Functionsintrophoblastdifferentiationandlateringastrulation,regulatingbothmesodermdelaminationandendodermspecification.PlaysaroleinbraindevelopmentbeingrequiredforthespecificationandtheproliferationoftheintermediateProgenitorcellsandtheirprogenyinthecerebralcortex.AlsoinvolvedinthedifferentiationofCD8+T-cellsduringimmuneresponseregulatingtheexpressionoflyticeffectorgenes.

SUBCELLULARLOCATION:NucleusProbable.

TISSUESPECIFICTY:ExpressedinCD8+T-cells.

DEVELOPMENTALSTAGE:Originallyexpressedinthetrophoectodermoftheblastocystandlaterintheextra-embryonicectodermoftheearlypost-implantationembryo.Intheembryoproper,expressedintheposteriorpartoftheepIBLast.Duringgastrulation,extendsdistallyintotheprimitivestreakandnascentmesoderm.Alsoexpressedinthedevelopingforebrainandtheolfactorylobes.ExpressedatE12.5andE14.5intheforebrain.

INDUCTION:Up-regulatedinCD8+T-cellsuponactivation.

DISRUPTIONPHENOTYPE:Embryoniclethalduetoperi-implantationdefects.Mutantembryosarrestsoonafterimplantationandfailtoformorganizedembryonicorextraembryonicstructures.Conditionalmutants,withexpressionabrogatedintheinnercellmassofembryosfromearlyimplantationstagesonward,displaygastrulationdefects.

SEQUENCESIMLARITIES:Contains1T-boxDNA-bindingdomain.
MolecularWeightN/A
PhysicochemicalInformation
Dimensions
MaterialsInformation
MaterialsInformation
品牌介绍
密理博(Millipore)公司成立于1954年,总部位于美国麻省,在全世界设有47个办事处,为100多个国家提供产品和技术服务。目前全球雇员超过5800人,在美国、法国和日本等国家拥有7家大型生产工厂,主要生产过滤膜及膜过滤产品。20世纪80年代,密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构,并于2000年4月在上海浦东外高桥保税区建立了密理博(上海)贸易有限公司。为了更好地满足中国用户的需求,密理博中国主页于2006年11月向广大用户开放,介绍密理博中国有限公司的最新动态,力求为用户打造专业的产品与服务信息交流平台。