Millipore/AB15894 | Anti-Tbr2 Antibody/AB15894/100 µg
市场价：
¥7180.00
美元价：
4308.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Description | |
|---|---|
| CatalogueNumber | AB15894 |
| Description | Anti-Tbr2Antibody |
| AlternateNames |
|
| BackgroundInformation | Eomesoderminhomolog(UniProtO54839;alsoknownasT-boxbrainprotein2,T-brain-2,TBR-2)isencodedbytheEomes(alsoknownasTbr2,C77258)gene(GeneID13813)inmurinespecies.Tbr2isamemberofaconservedproteinfamilythatsharesacommonDNA-bindingdomain,theT-box.T-boxgenesencodetranscriptionfactorsinvolvedintheregulationofdevelopmentalprocesses.Trb2hasbeenshowntoplayaroleinthedevelopmentoftheneocortexandfunctionsinthedifferentiationpathwayofrADIalgliatopost-mitoticprojectionneuron. |
| ProductInformation | |
|---|---|
| Format | AffinityPurified |
| Control |
|
| Presentation | Purifiedchickenpolyclonalantibodyinbuffercontaining0.1MTris-Glycine(pH7.4),150mMNaClwith0.05%sodiumazide. |
| StorageandShippingInformation | |
|---|---|
| StorageConditions | Stablefor1yearat2-8°Cfromdateofreceipt. |
| BIOLOGicalInformation | |
|---|---|
| Immunogen | KLH-conjugatedlinearpeptidecorrespondingtomouseTbr2. |
| Epitope | TranscriptionActivationDomain |
| Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. |
| Host | Chicken |
| Specificity | ExpectedtoreactwithbothsplicedisoformsofmurineTbr2. |
| Isotype | IgY |
| SpeciesReactivity |
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| AntibodyType | PolyclonalAntibody |
| EntrezGeneNumber | |
| GeneSymbol |
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| PurificationMethod | AffinityPurfied |
| UniProtNumber | |
| UniProtSummary | FUNCTION:Functionsasatranscriptionalactivatorplayingacrucialroleduringdevelopment.Functionsintrophoblastdifferentiationandlateringastrulation,regulatingbothmesodermdelaminationandendodermspecification.PlaysaroleinbraindevelopmentbeingrequiredforthespecificationandtheproliferationoftheintermediateProgenitorcellsandtheirprogenyinthecerebralcortex.AlsoinvolvedinthedifferentiationofCD8+T-cellsduringimmuneresponseregulatingtheexpressionoflyticeffectorgenes. SUBCELLULARLOCATION:NucleusProbable. TISSUESPECIFICTY:ExpressedinCD8+T-cells. DEVELOPMENTALSTAGE:Originallyexpressedinthetrophoectodermoftheblastocystandlaterintheextra-embryonicectodermoftheearlypost-implantationembryo.Intheembryoproper,expressedintheposteriorpartoftheepIBLast.Duringgastrulation,extendsdistallyintotheprimitivestreakandnascentmesoderm.Alsoexpressedinthedevelopingforebrainandtheolfactorylobes.ExpressedatE12.5andE14.5intheforebrain. INDUCTION:Up-regulatedinCD8+T-cellsuponactivation. DISRUPTIONPHENOTYPE:Embryoniclethalduetoperi-implantationdefects.Mutantembryosarrestsoonafterimplantationandfailtoformorganizedembryonicorextraembryonicstructures.Conditionalmutants,withexpressionabrogatedintheinnercellmassofembryosfromearlyimplantationstagesonward,displaygastrulationdefects. SEQUENCESIMLARITIES:Contains1T-boxDNA-bindingdomain. |
| MolecularWeight | ~85/95kDaobserved.Targetbandsappearlargerthanthecalculatedmolecularsizeof74.8kDa(isoform1)and72.7kDa(isoform2). |
| PhysicochemicalInformation |
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| Dimensions |
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| MaterialsInformation |
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| MaterialsInformation |
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品牌介绍
密理博(Millipore)公司成立于1954年，总部位于美国麻省，在全世界设有47个办事处，为100多个国家提供产品和技术服务。目前全球雇员超过5800人，在美国、法国和日本等国家拥有7家大型生产工厂，主要生产过滤膜及膜过滤产品。20世纪80年代，密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构，并于2000年4月在上海浦东外高桥保税区建立了密理博（上海）贸易有限公司。为了更好地满足中国用户的需求，密理博中国主页于2006年11月向广大用户开放，介绍密理博中国有限公司的最新动态，力求为用户打造专业的产品与服务信息交流平台。
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