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Millipore/AB152 | Anti-Tyrosine Hydroxylase Antibody/AB152/100 µL
Millipore/AB152 | Anti-Tyrosine Hydroxylase Antibody/AB152/100 µL
市场价：
¥6980.00
美元价：
4188.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Description | |
|---|---|
| CatalogueNumber | AB152 |
| BrandFamily | Chemicon® |
| TradeName |
|
| Description | Anti-TyrosineHydroxylaseAntibody |
| AlternateNames |
|
| BackgroundInformation | Tyrosinehydroxylase(alsoknowasTyrosine3-hydroxylaseandTyrosine3-monooxygenase)playsanimportantroleinthephysiologyofadrenergicneurons.Itisthefirstandrate-limitingenzymeinvolvedinthebiosynthesisofthecatecholaminesDopamineandNorepinephrinefromtyrosine.THis,therefore,ausefulMarkerfordopaminergicandnoradrenergicneurons.TheenzymaticactivityofTHrequiresferrousionsascofactorsandisbelievedtoberegulatedbyphosphorylation.AtleastfourisoformsofhumanTHhavebeenidentifiedwhichresultfromalternativesplicing. |
| ProductInformation | |
|---|---|
| Format | AffinityPurified |
| Control |
|
| Presentation | Purifiedrabbitpolyclonalinbuffercontainingliquidin10mMHEPES(pH7.5),150mMNaCl(pH7.5),100ug/mLBSAand50%glycerol. |
| StorageandShippingInformation | |
|---|---|
| StorageConditions | Maintainfrozenat-20ºCto-70ºCinundilutedaliquotsforupto6monthsafterdateofreceipt.Avoidrepeatedfreeze/thawcycles.Donotstoreinaselfdefrostingfreezer. |
| Applications | |
|---|---|
| Application | Anti-TyrosineHydroxylaseAntibodydetectslevelofTHandhasbeenpublishedandvalidatedforuseinELISA,IF,IH,IH(P),IPandWB. |
| KeyApplications |
|
| ApplicationNotes | Immunohistochemistry: Apreviouslotofthisantibodywasuesdat1:100-1:1,000dilution,4°C,for1-3days.Stainsbothfreshfrozenandparaffinembeddedtissuesamplesbyindirectimmunofluorescenceandimmunoperoxidase. Immunofluorescence: Apreviouslotofthisantibodywasusedat1:100-1:1,000dilution. Immunoprecipitation: ApreviouslotofthisantibodywasusedonImmunoprecipitation. ELISA: ApreviouslotofthisantibodywasusedinELISA. Optimaldilutionsmustbedeterminedbytheenduser. |
| BIOLOGicalInformation | |
|---|---|
| Immunogen | Denaturedtyrosinehydroxylasefromratpheochromocytoma(denaturedbysodiumdodecylsulfate). |
| Host | Rabbit |
| Specificity | Tyrosinehydroxylase.Bywesternblot,AB152selectivelabelsasinglebandatapproximately62kDa(reduced)correspondingtoTyrosineHydroxylase.Itisexpectedthattheantibodywillreactwithmostmammalianandmanynon-mammalianspecies.Ithasbeenreportedthatthisantibodydoesnotworkonparaffinembeddedhumantissue. |
| SpeciesReactivity |
|
| SpeciesReactivityNote | Rat,mouse,ferret,feline,Aplysia(marinemollusc).Itisexpectedthattheantibodywillreactwithmostmammalianandmanynon-mammalianspecies.Ithasbeenreportedthatthisantibodydoesnotworkonparaffinembeddedhumantissue. |
| AntibodyType | PolyclonalAntibody |
| EntrezGeneNumber | |
| EntrezGeneSummary | Tyrosinehydroxylaseisinvolvedintheconversionoftyrosinetodopamine.Astherate-limitingenzymeinthesynthesisofcatecholamines,tyrosinehydroxylasehasakeyroleinthephysiologyofadrenergicneurons. |
| GeneSymbol |
|
| PurificationMethod | AffinityPurfied |
| UniProtNumber | |
| UniProtSummary | FUNCTION:SwissProt:P07101#Playsanimportantroleinthephysiologyofadrenergicneurons. COFACTOR:Fe(2+)ion. SIZE:528aminoacids;58524Da TISSUESPECIFICITY:Mainlyexpressedinthebrainandadrenalglands. DISEASE:SwissProt:P07101#DefectsinTHarethecauseofautosomalrecessiveSegawasyndrome[MIM:605407];alsoknownasDOPA-responsivedystonia.Typically,itbeginsinchildhoodoradolescencewithprogressivedifficultyinwalkingand,insomecases,spasticity.Somecasespresentwithparkinsoniansymptomsininfancyandarereferredtoasautosomalrecessiveinfantileparkinsonism. SIMILARITY:SwissProt:P07101##Belongstothebiopterin-dependentaromaticaminoacidhydroxylasefamily. |
| MolecularWeight | 62kDa |
| PhysicochemicalInformation |
|---|
| Dimensions |
|---|
| MaterialsInformation |
|---|
| MaterialsInformation |
|---|
品牌介绍
密理博(Millipore)公司成立于1954年，总部位于美国麻省，在全世界设有47个办事处，为100多个国家提供产品和技术服务。目前全球雇员超过5800人，在美国、法国和日本等国家拥有7家大型生产工厂，主要生产过滤膜及膜过滤产品。20世纪80年代，密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构，并于2000年4月在上海浦东外高桥保税区建立了密理博（上海）贸易有限公司。为了更好地满足中国用户的需求，密理博中国主页于2006年11月向广大用户开放，介绍密理博中国有限公司的最新动态，力求为用户打造专业的产品与服务信息交流平台。
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