密理博/AB2033 |抗纤维连接蛋白抗体/AB2033/100µ；G
市场价：
¥6780.00
美元价：
4068.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Description | |
|---|---|
| CatalogueNumber | AB2033 |
| BrandFamily | Chemicon® |
| TradeName |
|
| Description | Anti-FibronectinAntibody |
| BackgroundInformation | Fibronectinisahighmolecularweightextracellularadhesionmoleculeinvolvedinmanycellularprocesses,includingtissuerepairorwoundhealing,embryogenesis,bloodclotting,andcellmigration/adhesion.Fibronectinexistsintwomajorforms:1)asaninsolubleglycoproteindimerthatservesasalinkerintheextracellularmatrix(ECM),and2)asasolubledisulfide-linkeddimerfoundintheplasma.Theplasmaformissynthesizedbyhepatocytes,andtheECMformismadebyfibroblasts,chondrocytes,endothelialcells,macrophages,aswellascertainepithelialcells.Fibronectinsometimesservesasageneralcelladhesionmoleculebyanchoringcellstocollagenorproteoglycansubstrates.ItcanalsoservetoorganizecellularinteractionwiththeECMbybindingtodifferentcomponentsoftheECMandtomembrane-boundfibronectinreceptorsoncellsurfaces.TheimmunogenforfibronectinpolyclonalantibodyAB2033ispurifiedmouseplasma.Theantibodyshowslessthan0.1%reactivitywithmouselaminin,andcollagentypesI,III,andIVbyrADIoimmunoassay. |
| ProductInformation | |
|---|---|
| Format | AffinityPurified |
| Control |
|
| Presentation | Purifiedrabbitpolyclonalinbuffercontaining0.01Mphosphate,0.09MNaCl,pH7.2withnopreservatives. |
| StorageandShippingInformation | |
|---|---|
| StorageConditions | Stablefor1yearat-20ºCfromdateofreceipt. |
| Applications | |
|---|---|
| Application | DetectFibronectinusingthisAnti-FibronectinAntibodyvalidatedforuseinELISA,IC,IH,RIA. |
| KeyApplications |
|
| ApplicationNotes | Immunohistochemistry: 1:80dilutionofapreviouslotwasusedinimmunofluorescentstainingoffrozenmouseskinandlivertissues. Radioimmunoassay: ApreviouslotofthisantibodywasusedinRIA. ELISA: A1:200dilutionofapreviouslotwasusedinELISA. Optimalworkingdilutionsmustbedeterminedbytheenduser. |
| BIOLOGicalInformation | |
|---|---|
| Immunogen | Fibronectinextractedandpurifiedfrommouseplasma. |
| Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. |
| Host | Rabbit |
| Specificity | Thisantibodyreactswithmousefibronectin.Showslessthan0.1%reactivitywithmouseLaminin,andCollagenTypesI,III,andIVbyradioimmunoassay. |
| SpeciesReactivity |
|
| AntibodyType | PolyclonalAntibody |
| EntrezGeneNumber | |
| EntrezGeneSummary | Thisgeneencodesfibronectin,aglycoproteinpresentinasolubledimericforminplasma,andinadimericormultimericformatthecellsurfaceandinextracellularmatrix.Fibronectinisinvolvedincelladhesionandmigrationprocessesincludingembryogenesis,woundhealing,bloodcoagulation,hostdefense,andmetastasis.Thegenehasthreeregionssubjecttoalternativesplicing,withthepotentialtoproduce20differenttranscriptvariants.However,thefull-lengthnatureofsomevariantshasnotbeendetermined. |
| GeneSymbol |
|
| PurificationMethod | ImmunoAffinityPurified |
| UniProtNumber | |
| UniProtSummary | FUNCTION:SwissProt:P02751#Fibronectinsbindcellsurfacesandvariouscompoundsincludingcollagen,fibrin,heparin,DNA,andactin.Fibronectinsareinvolvedincelladhesion,cellmotility,opsonization,woundhealing,andmaintenanceofcellshape.InteractionwithTNRmediatesinhibitionofcelladhesionandneuriteoutgrowth(Bysimilarity). SIZE:2386aminoacids;262607Da SUBUNIT:Mostlyheterodimersormultimersofalternativelysplicedvariants,connectedby2disulfidebondsnearthecarboxylends;toalesserextenthomodimers.InteractswithFBLN1,AMBP,TNR,LGALS3BPandCOL13A1. SUBCELLULARLOCATION:Secreted,extracellularspace,extracellularmatrix. TISSUESPECIFICITY:PlasmaFN(solubledimericform)issecretedbyhepatocytes.CellularFN(dimericorcross-linkedmultimericforms),madebyfibroblasts,epithelialandothercelltypes,isdepositedasfibrilsintheextracellularmatrix.Ugl-Y1,Ugl-Y2andUgl-Y3arefoundinurine. DEVELOPMENTALSTAGE:Ugl-Y1,Ugl-Y2andUgl-Y3arepresentintheurinefrom0to17yearsofage. PTM:Sulfated. SIMILARITY:SwissProt:P02751##Contains12fibronectintype-Idomains.&Contains2fibronectintype-IIdomains.&Contains16fibronectintype-IIIdomains |
| PhysicochemicalInformation |
|---|
| Dimensions |
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| MaterialsInformation |
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| MaterialsInformation |
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品牌介绍
密理博(Millipore)公司成立于1954年，总部位于美国麻省，在全世界设有47个办事处，为100多个国家提供产品和技术服务。目前全球雇员超过5800人，在美国、法国和日本等国家拥有7家大型生产工厂，主要生产过滤膜及膜过滤产品。20世纪80年代，密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构，并于2000年4月在上海浦东外高桥保税区建立了密理博（上海）贸易有限公司。为了更好地满足中国用户的需求，密理博中国主页于2006年11月向广大用户开放，介绍密理博中国有限公司的最新动态，力求为用户打造专业的产品与服务信息交流平台。
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