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Millipore/17-320 | Histone Deacetylase Assay Kit (HDAC)/17-320/1 kitKit capacity: 100 assays
Millipore/17-320 | Histone Deacetylase Assay Kit (HDAC)/17-320/1 kitKit capacity: 100 assays
市场价：
¥6580.00
美元价：
3948.00
产品分类：
夹心法ELISA
公司分类：
Sandwich_method_ELISA
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Description | |
|---|---|
| CatalogueNumber | 17-320 |
| BrandFamily | Upstate |
| TradeName |
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| Description | HistoneDeacetylaseAssayKit(HDAC) |
| Overview | ThiskitcontainsnonrADIoactivecomponentsforradiolabelingandpurifyinghistoneH4peptidewith[3H]-acetylCoA.TheradiolabeledpeptideisasuitablesubstrateforassayofHDACactivity.HeLanuclearextract,whichisrichinhistonedeacetylaseactivity,isincludedasapositivecontrol.TheHDACinhibitorsodiumbutyrateisprovidedtodemonstratespecificityofthedeacetylaseactivity. |
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| BIOLOGicalInformation | |
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| EntrezGeneNumber | |
| EntrezGeneSummary | Histonesplayacriticalroleintranscriptionalregulation,cellcycleprogression,anddevelopmentalevents.Histoneacetylation/deacetylationalterschromosomestructureandaffectstranscriptionfactoraccesstoDNA.TheproteinencodedbythisgenebelongstotheclassIIhistonedeacetylase/acuc/aphafamily.Itpossesseshistonedeacetylaseactivityandrepressestranscriptionwhentetheredtoapromoter.ItcoimmunoprecipitatesonlywithHDAC3familymemberandmightformmulticomplexproteins.Italsointeractswithmyocyteenhancerfactor-2(MEF2)proteins,resultinginrepressionofMEF2-dependentgenes.Thisgeneisthoughttobeassociatedwithcoloncancer.Twotranscriptvariantsencodingdifferentisoformshavebeenfoundforthisgene. |
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| UniProtNumber | |
| UniProtSummary | FUNCTION:SwissProt:Q9UQL6#ResponsIBLeforthedeacetylationoflysineresiduesontheN-terminalpartofthecorehistones(H2A,H2B,H3andH4).Histonedeacetylationgivesatagforepigeneticrepressionandplaysanimportantroleintranscriptionalregulation,cellcycleprogressionanddevelopmentalevents.Histonedeacetylasesactviatheformationoflargemultiproteincomplexes.InvolvedinmusclematurationbyrepressingtranscriptionofmyocyteenhancerMEF2C.Duringmuscledifferentiation,itshuttlesintothecytoplasm,allowingtheexpressionofmyocyteenhancerfactors. SIZE:1122aminoacids;121992Da SUBUNIT:InteractswithBCOR,HDAC7,HDAC9,CTBP1,MEF2C,NCOR2,NRIP1,PHB2anda14-3-3chaperoneprotein.InteractswithJARID1B. SUBCELLULARLOCATION:Nucleus.Cytoplasm.Note=Shuttlesbetweenthenucleusandthecytoplasm.Inmusclecells,itshuttlesintothecytoplasmduringmyocytedifferentiation.Theexporttocytoplasmdependsontheinteractionwitha14-3-3chaperoneproteinandisduetoitsphosphorylationatSer-259andSer-498byCaMK.TISSUESPECIFICITY:Ubiquitous.DOMAIN:SwissProt:Q9UQL6Thenuclearexportsequencemediatestheshuttlingbetweenthenucleusandthecytoplasm(Bysimilarity). PTM:PhosphorylatedbyCaMKatSer-259andSer-498.Thephosphorylationisrequiredfortheexporttothecytoplasm.&Ubiquitinated.Polyubiquitinationhoweverdoesnotleadtoitsdegradation. SIMILARITY:Belongstothehistonedeacetylasefamily.Type2subfamily. |
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品牌介绍
密理博(Millipore)公司成立于1954年，总部位于美国麻省，在全世界设有47个办事处，为100多个国家提供产品和技术服务。目前全球雇员超过5800人，在美国、法国和日本等国家拥有7家大型生产工厂，主要生产过滤膜及膜过滤产品。20世纪80年代，密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构，并于2000年4月在上海浦东外高桥保税区建立了密理博（上海）贸易有限公司。为了更好地满足中国用户的需求，密理博中国主页于2006年11月向广大用户开放，介绍密理博中国有限公司的最新动态，力求为用户打造专业的产品与服务信息交流平台。
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