Millipore/07-937 | Anti-HDAC7 Antibody/07-937/100 µL
市场价：
¥7800.00
美元价：
4680.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Description | |
|---|---|
| CatalogueNumber | 07-937 |
| Description | Anti-HDAC7Antibody |
| AlternateNames |
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| BackgroundInformation | Histonedeacetylases(HDAC)areenzymesthatregulatestranscriptionbyselectivelydeacetylatingtheeta-aminogroupsoflysineslocatedneartheaminoterminiofcorehistoneproteins.EightmembersoftheHDACfamilyhavebeenidentified,dividedintotwoclasses.ClassIincludesHDAC-1,2,3and8whileClassIIincludesHDAC-4,5,6,and7.HumanHDAC7iscomposedof912aminoacidresidues.AlthoughHDAC7islocalizedmostlytothecellnucleus,itisalsofoundinthecytoplasm,suggestingnucleo-cytoplasmicshuttling.ThehistonedeacetylaseactivityofHDAC7mapstoaC-terminaldomainandisdependentoninteractionwithclassIHDACsinthenucleus.Itisanactivecomponentofdifferenttranscriptionalco-repressorcomplexesthatcanberecruitedtospecificpromoterregionsviainteractionswithtranscriptionfactors.HDAC7catalyzesremovalofacetyl-groupsfromacetyl-lysinesofhistones,resultinginatighterDNA-histoneinteraction.ThiscompactionofchromatinleadstotherepressionoftranscriptionofDNAinthatregion. |
| ProductInformation | |
|---|---|
| Format | AffinityPurified |
| Control |
|
| Presentation | PurifiedRabbitpolyclonalinbuffercontaining20mMPBSand0.1%sodiumazide. |
| StorageandShippingInformation | |
|---|---|
| StorageConditions | Stablefor1yearat2-8ºCfromdateofreceipt. |
| BIOLOGicalInformation | |
|---|---|
| Immunogen | Syntheticpeptidecorrespondingtoaminoacids164-182ofhumanHDAC7[(C)KPKKSLERRKNPLLRKESA]. |
| Epitope | a.a.164-182 |
| Host | Rabbit |
| Specificity | ThisantibodyrecognizeshumanHDAC7.Doesnotcross-reactwithHDAC1,HDAC4,orHDAC8. |
| SpeciesReactivity |
|
| SpeciesReactivityNote | ReactswithHuman.Nottestedwithotherspecies. |
| AntibodyType | PolyclonalAntibody |
| EntrezGeneNumber | |
| EntrezGeneSummary | Histonesplayacriticalroleintranscriptionalregulation,cellcycleprogression,anddevelopmentalevents.Histoneacetylation/deacetylationalterschromosomestructureandaffectstranscriptionfactoraccesstoDNA.Theproteinencodedbythisgenehassequencehomologytomembersofthehistonedeacetylasefamily.ThisgeneisorthologoustomouseHDAC7genewhoseproteinpromotesrepressionmediatedviathetranscriptionalcorepressorSMRT.Alternativelysplicedtranscriptvariantsencodingdifferentisoformshavebeenfoundforthisgene.[providedbyRefSeq]. |
| GeneSymbol |
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| PurificationMethod | AffinityPurfied |
| UniProtNumber | |
| UniProtSummary | FUNCTION:ResponsIBLeforthedeacetylationoflysineresiduesontheN-terminalpartofthecorehistones(H2A,H2B,H3andH4).Histonedeacetylationgivesatagforepigeneticrepressionandplaysanimportantroleintranscriptionalregulation,cellcycleprogressionanddevelopmentalevents.Histonedeacetylasesactviatheformationoflargemultiproteincomplexes.InvolvedinmusclematurationbyrepressingtranscriptionofmyocyteenhancerfactorssuchasMEF2A,MEF2BandMEF2C.Duringmuscledifferentiation,itshuttlesintothecytoplasm,allowingtheexpressionofmyocyteenhancerfactorsBysimilarity.MaybeinvolvedinEpstein-Barrvirus(EBV)latency,possiblybyrepressingtheviralBZLF1gene. CatalyticactivityHydrolysisofanN(6)-acetyl-lysineresidueofahistonetoyieldadeacetylatedhistone. SUBUNIT:InteractswithHDAC1,HDAC2,HDAC3,HDAC4,HDAC5,NCOR1,NCOR2,SIN3A,SIN3B,RBBP4,RBBP7,MTA1L1,SAP30andMBD3.Interactswiththe14-3-3proteinYWHAE,MEF2A,MEF2BandMEF2CBysimilarity.InteractswithHTATIPandEDNRA.InteractswithJARID1B. SUBCELLULARLOCATION:Nucleus.Cytoplasm.Note=Inthenucleus,itassociateswithdistinctsubnucleardot-likestructures.Shuttlesbetweenthenucleusandthecytoplasm.TreatmentwithEDN1resultsinshuttlingfromthenucleustotheperinuclearregion.Theexporttocytoplasmdependsontheinteractionwiththe14-3-3proteinYWHAEandmaybeduetoitsphosphorylation. DOMAIN:ThenuclearexportsequencemediatestheshuttlingbetweenthenucleusandthecytoplasmBysimilarity. PTM:MaybephosphorylatedbyCaMK1Bysimilarity. MISCELLANEOUS:ItsactivityisinhibitedbyTrichostatinA(TSA),aknownhistonedeacetylaseinhibitorBysimilarity. SIMILARITY:Belongstothehistonedeacetylasefamily.Type2subfamily. |
| MolecularWeight | 100kDa |
| PhysicochemicalInformation |
|---|
| Dimensions |
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| MaterialsInformation |
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| MaterialsInformation |
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品牌介绍
密理博(Millipore)公司成立于1954年，总部位于美国麻省，在全世界设有47个办事处，为100多个国家提供产品和技术服务。目前全球雇员超过5800人，在美国、法国和日本等国家拥有7家大型生产工厂，主要生产过滤膜及膜过滤产品。20世纪80年代，密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构，并于2000年4月在上海浦东外高桥保税区建立了密理博（上海）贸易有限公司。为了更好地满足中国用户的需求，密理博中国主页于2006年11月向广大用户开放，介绍密理博中国有限公司的最新动态，力求为用户打造专业的产品与服务信息交流平台。
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