密理博/07-1548 |抗HDAC11抗体/07-1548/100µ；G
市场价：
¥7800.00
美元价：
4680.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Description | |
|---|---|
| CatalogueNumber | 07-1548 |
| Description | Anti-HDAC11Antibody |
| AlternateNames |
|
| BackgroundInformation | HDAC11isresponsIBLeforthedeacetylationoflysineresiduesontheN-terminalpartofthecorehistones(H2A,H2B,H3andH4).HistonedeacetylationisaMarkerforepigeneticrepressionandplaysanimportantroleintranscriptionalregulation,cellcycleprogressionanddevelopmentalevents.Histonedeacetylasesactviatheformationoflargemultiproteincomplexes.ThepredominantlynuclearHDAC11,whichinteractswithHDAC6,isweaklyexpressedinmosttissues,andstronglyexpressedinbrain,heart,skeletalmuscle,kidneyandtestis.Itsactivityisinhibitedbytrapoxin,aknownhistonedeacetylaseinhibitor. |
| ProductInformation | |
|---|---|
| Format | Purified |
| Control |
|
| Presentation | Purifiedrabbitpolyclonalinbuffercontaining0.09%NaN3. |
| StorageandShippingInformation | |
|---|---|
| StorageConditions | Stablefor6monthsat2-8°Cfromdateofreceipt.Forlongtermstorage,storeat-20ºC.HandlingRecommendations:Uponreceiptandpriortoremovingthecap,centrifugethevialandgentlymixthesolution.Aliquotintomicrocentrifugetubesandstoreat-20°C.Avoidrepeatedfreeze/thawcycles,whichmaydamageIgGandaffectproductperformance. |
| Applications | |
|---|---|
| Application | UseAnti-HDAC11Antibody(RabbitPolyclonalAntibody)validatedinWB,ELISA,IHCtodetectHDAC11alsoknownashistonedeacetylase11. |
| KeyApplications |
|
| ApplicationNotes | ELISA: ThisantibodyhasbeenshownbyanoutsidelaboratorytobesuitableforELISA(1:1000). Immunohistochemistry: Thisantibodyhasbeenshownbyanoutsidelaboratorytobesuitableforhistochemistryusingformalinfixed,paraffinembeddedhumanhepatocarcinomatissue(1:50-1:100). |
| BIOLOGicalInformation | |
|---|---|
| Immunogen | TheimmunogenwasaKLH-conjugatedsyntheticpeptidecorrespondingtheN-terminalregionofhumanHDAC11. |
| Epitope | N-terminus |
| Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. |
| Host | Rabbit |
| Specificity | ThisantibodyrecognizesHDAC11. |
| SpeciesReactivity |
|
| SpeciesReactivityNote | Human,Mouse.Nottestedinotherspecies. |
| AntibodyType | PolyclonalAntibody |
| EntrezGeneNumber | |
| EntrezGeneSummary | ThisgeneencodesaclassIVhistonedeacetylase.Theencodedproteinislocalizedtothenucleusandmaybeinvolvedinregulatingtheexpressionofinterleukin10.Alternativesplicingresultsinmultipletranscriptvariants. TranscriptVariant:Thisvariant(1)representsthelongertranscriptandencodesthelongerisoform(1). |
| GeneSymbol |
|
| PurificationMethod | ProteinGChromatography |
| UniProtNumber | |
| UniProtSummary | FUNCTION:ResponsibleforthedeacetylationoflysineresiduesontheN-terminalpartofthecorehistones(H2A,H2B,H3andH4).Histonedeacetylationgivesatagforepigeneticrepressionandplaysanimportantroleintranscriptionalregulation,cellcycleprogressionanddevelopmentalevents.Histonedeacetylasesactviatheformationoflargemultiproteincomplexes.Ref.4 CatalyticactivityHydrolysisofanN(6)-acetyl-lysineresidueofahistonetoyieldadeacetylatedhistone. SUBUNITSTRUCTURE:InteractswithHDAC6.Ref.4 SUBCELLULARLOCATION:Nucleus.Note=Predominantlynuclear. TISSUESPECIFICITY:Weaklyexpressedinmosttissues.Stronglyexpressedinbrain,heart,skeletalmuscle,kidneyandtestis. MISCELLANEOUS:Itsactivityisinhibitedbytrapoxin,aknownhistonedeacetylaseinhibitor. SEQUENCESIMILARITY:Belongstothehistonedeacetylasefamily. SEQUENCECAUTION:ThesequenceBAB15127.1differsfromthatshown.Reason:Erroneousterminationatposition107.TranslatedasGln. ThesequenceCAB70712.1differsfromthatshown.Reason:Frameshiftatpositions177,198and200. |
| MolecularWeight | ~40kDa |
| PhysicochemicalInformation |
|---|
| Dimensions |
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| MaterialsInformation |
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| MaterialsInformation |
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品牌介绍
密理博(Millipore)公司成立于1954年，总部位于美国麻省，在全世界设有47个办事处，为100多个国家提供产品和技术服务。目前全球雇员超过5800人，在美国、法国和日本等国家拥有7家大型生产工厂，主要生产过滤膜及膜过滤产品。20世纪80年代，密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构，并于2000年4月在上海浦东外高桥保税区建立了密理博（上海）贸易有限公司。为了更好地满足中国用户的需求，密理博中国主页于2006年11月向广大用户开放，介绍密理博中国有限公司的最新动态，力求为用户打造专业的产品与服务信息交流平台。
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